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Entry version 11 (22 Apr 2020)
Sequence version 1 (05 Oct 2016)
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Protein
Submitted name:

Erythrocyte membrane protein 1

Gene

var

Organism
Plasmodium falciparum
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Erythrocyte membrane protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:varImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPlasmodium falciparumImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5833 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaSarAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3045 – 3066HelicalSequence analysisAdd BLAST22

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini377 – 520PFEMPInterPro annotationAdd BLAST144

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni518 – 539DisorderedSequence analysisAdd BLAST22
Regioni1717 – 1839DisorderedSequence analysisAdd BLAST123
Regioni2178 – 2198DisorderedSequence analysisAdd BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili17 – 44Sequence analysisAdd BLAST28
Coiled coili177 – 208Sequence analysisAdd BLAST32
Coiled coili470 – 490Sequence analysisAdd BLAST21
Coiled coili2074 – 2094Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi518 – 534PolarSequence analysisAdd BLAST17
Compositional biasi1767 – 1796PolyampholyteSequence analysisAdd BLAST30
Compositional biasi1807 – 1839PolarSequence analysisAdd BLAST33
Compositional biasi2178 – 2196PolarSequence analysisAdd BLAST19

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1310.20, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004258, DBL
IPR042202, Duffy-ag-bd_sf
IPR008602, Duffy-antigen-binding

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05424, Duffy_binding, 7 hits
PF03011, PFEMP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

A0A191VZ36-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DIVRGKDLFL GAPNKEKIKL EENLKKIFDN IKNENAELSK LSLEKVREYW
60 70 80 90 100
WAIHRKELWE ALTCSAPKGA NYFVYKLDRP KFSSDRCGHN YNGDPLTNLD
110 120 130 140 150
YVPQYLRWFD EWGEEFCRKR KIKLENVEKA CRKDSEKLYC RHNGYDCTKT
160 170 180 190 200
IKNENILFDD PKCTDCLIKC SLYEIWLDNQ QKEFEKQKEK YEKEIQTYIS
210 220 230 240 250
NNEISNNNIS NEYNKQISEK YTDKKYETLD KFLNLLKEGK YCKERMTGES
260 270 280 290 300
SIDFNNDVDK TFSYSKHCKV CPHCEVDCEN GNCEVKNKPD GNCGKNVKYK
310 320 330 340 350
PPYGVKPTEI TVLYSGNEKG DISKKLSEFC SNKNNINVKN NETWKCYYKN
360 370 380 390 400
SDNNKCKMES NSENNKGAEK ITSFHEFFEL WVKNLLKDTM KWENEIKDCI
410 420 430 440 450
NNTNITDCND ECNKNCVCFD KWVKQKEEEW KNVKKVFENK KYIQDKYYLD
460 470 480 490 500
INKLFESFLF KVISELDQGE AKWNQLKEEL KKKIESSKAN EGIKDSESAI
510 520 530 540 550
ELLLDHLKES ATTCKDNNAN EACSSSQKSS PNPCADKSGG KLVSVKQIAQ
560 570 580 590 600
YIKRQAYEQA NYRSDGLHKL KGKAHEGKYK RKGRENYFKD KLCKIGKYHS
610 620 630 640 650
NRDPFESKGP CYGKDGNKLS FQIGTDWKGA EEEKMIYNDV YLPPRREHMC
660 670 680 690 700
TSNLEHLVTD NKPLDGTDGN PKLVNNSFLG DVLLSAKYEA QRTKEDYEPV
710 720 730 740 750
SDEQSICRAV RYSFADLADI IRGRDMWDKD DGAQKMERIL KSIFKNIYET
760 770 780 790 800
IGDKKGKYTN TDGKYLELRE DWWEANRAKV WEAMKCAIKG LNVTSSDGKL
810 820 830 840 850
SDHCGYSDHT PLDDYIPQKL RWMAEWAEWY CKVQSQEYDK LKKSCVMCMQ
860 870 880 890 900
KDNGKNCWKH NSECGVCKGA CTAYQGKLLP WEYQWNVISH KYETLYEKAR
910 920 930 940 950
IAADNGGLDT SSGDIDPKDK TLVEFLFNLY VQNGGKIGTI GTTGDKDTRD
960 970 980 990 1000
TTPTVYSTAA GYIHEEAHIG DCKEQKKFCE KKNGAKPPSG DLEVDNEYAF
1010 1020 1030 1040 1050
RDKPTDHDKV CDCESGEKLQ YKKKEGIVLE EPCNVVKTLL KDKNENSDIG
1060 1070 1080 1090 1100
QCIRKYKDGN EKYPVWDCTR NKIKIGEGAY MPPRRQKLCV DFLKQLKDQT
1110 1120 1130 1140 1150
DEKLRDAFIK SAAAETFLSW HKYKEDTQKE KATHTADNDL NKGIIPEDFI
1160 1170 1180 1190 1200
RQMYYTFGDY RDLCMNKNIG NDVSNVESKI EGVFSKADGT SSSNLSREVW
1210 1220 1230 1240 1250
WKKHGPKIWE GMLCALPGTE NFKNKADYKN PPEDFAKQPQ FLRWLTEWYD
1260 1270 1280 1290 1300
DYCHTRQKYL TRVESTCKLN DQSQCAAECN NKCDEYKKYM EGKKKEWDAQ
1310 1320 1330 1340 1350
YKYYKEQRNK KEVVNDSKGI IVKDYVLANA KEYLKKKFTA ICVTSSGKAQ
1360 1370 1380 1390 1400
NSATEEVKKN IELLSEEQYY DANEHCGCTK FIHDGKYSKI SGRSNCYGLN
1410 1420 1430 1440 1450
SDAKKNKIKW RNGDEKDYAF LKKRNLSGEV FFPSRRLGIC FRGLDGYYRY
1460 1470 1480 1490 1500
PEVKDKDTLR KTLMEVAATE GYNLGQYYKE KKKANKEAYR YSYEVRPYSA
1510 1520 1530 1540 1550
MKYSFYDLRD IILGYDNLED NSTTTEKNMK EIFKSESNEG SQGRQTFWNN
1560 1570 1580 1590 1600
NKDCVWEAMK CGYNKSGETI PDECKNMPRD SDYPIASNRD EGTAYQFLRW
1610 1620 1630 1640 1650
FAEWGEDFCK HKEKELKKLV GACNDYNCGD NEDKKKKCTS ACTQYKQFIS
1660 1670 1680 1690 1700
EWKPQYENQI KKYGKHKHKI YSEHPVAKDA KDAREYLDKQ LQKFCENKSG
1710 1720 1730 1740 1750
DCEYNCMKDA STQLLTDGHS QNMPASLEDE PKEVEGKCNC PVPPGRPRAR
1760 1770 1780 1790 1800
RETPSPRVPL TAKATTSKKE AKTEPSTKPP KKVEKPRTEI QSPARKRTRR
1810 1820 1830 1840 1850
AAQQTRTRTV REAPQAPTQT ARAAPQELTR TSTPTTTPSD VATMIKDIFS
1860 1870 1880 1890 1900
KKRDRKGGIE NCYPKTNGQY PQWDCNPRKF KENENGPCMP PRRKKLCINN
1910 1920 1930 1940 1950
LQYLNNKTET KNENDIKEAF IKCTAIETHF LWKRYKGNND EVDEKLKYGD
1960 1970 1980 1990 2000
IPKDFIRIMF YTFGDYRDIF FGTDICKDKN IDTISQNVEK LLKKKKDNIS
2010 2020 2030 2040 2050
KNIDEVKRYY WEQYGPDIWK GMLYGLTYHL KDEGKNRIPE DSKYQYNKLK
2060 2070 2080 2090 2100
PDLEEFAKRP QFLRWFTEWA EEFCNKRKEQ LKKLEAGCKE YECNGSDDGK
2110 2120 2130 2140 2150
TQECAEACVT YQKFIKKWKT EYERQREKFK KDKDGKKYKD YPSTERDIEK
2160 2170 2180 2190 2200
ATCAHEYLNM KLKELCGNKD CSCMQKPSSQ LPKTTQQSQS SDANDMPESL
2210 2220 2230 2240 2250
DYVPEEFNKC ECPELSKKGS MIHTKKITEP KIPMNCVEKA AYYLSKEAEN
2260 2270 2280 2290 2300
NMDITLKEKF IPIESTKEKE SKNSWTNNNP CDPKKPYSPH KYVSINPCEG
2310 2320 2330 2340 2350
KGKDRFKVHS ELKCYKNLKG YTETKTVCVP PRREHMCLRN LNEIKIERLK
2360 2370 2380 2390 2400
DSNYLLKMVR RTARNEGIDI IKNFNSENGC AMNPICDTMK YSFADLGDIV
2410 2420 2430 2440 2450
RGTDMLRIGG YLPPVEIKLY KVFEYIYGKW RNKNKGRNKY NDVQTFRSAW
2460 2470 2480 2490 2500
WDANRKDIWK AMTCKAPEDA KLFRKGRMDG FERITLIQDK CGHKDDPPVD
2510 2520 2530 2540 2550
DYIPQRFRWM TEWSEYYCKA LIDELEKFKK SCDHCKTTDR CKNDYDKNKC
2560 2570 2580 2590 2600
EECKTRCQEY KNFVLKWKSL FDIQSNKYKE LYEQPIDTKI SAYDHVQNFV
2610 2620 2630 2640 2650
QKLKSFKSEC SVESFSEYLH ETSKCLNYKF NENDGSNIRS YAFEETPKSY
2660 2670 2680 2690 2700
KEACSCTLHS KNPLDNCPTD QNKDGCKELQ TCTFCSKNDY DNNLDNWNAY
2710 2720 2730 2740 2750
LVRNSSDDNK GVLIPPRRRH LCTRPITAYN YRKGDKEILK KKLLTSAFSQ
2760 2770 2780 2790 2800
GQLLGQKYKS EKELCFEAMK YSYADYSDII KGTDMMDTSL SEKIKKIFET
2810 2820 2830 2840 2850
SNQDTEDCKT WWEKNRSHVW HAMLCGYKIA TSNVTLDEGW CELPKDEETN
2860 2870 2880 2890 2900
QFLRWLIEWA KQACKEKKHI TNSLKTKCRC SNKDNFKASE LLRQPGCQND
2910 2920 2930 2940 2950
IRKYISLNIL IQNSMENLNI KYKKFKDQSS GNIDNKPSEE NVQSYIKSKD
2960 2970 2980 2990 3000
SQCALELNDI NEIVTGTKNN ENNEFKEVLK KLYPGLYFVE DETHKNHVLD
3010 3020 3030 3040 3050
GNIKEEEQTV RPEVLYFFTP HVDYLYQGLF LPTYRGEKYD PKNDILKSSI
3060
SVVIVSALGL IALLFMK
Length:3,067
Mass (Da):358,235
Last modified:October 5, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFF6EAFA9D6D6422B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1
Non-terminal residuei3067Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KX154858 Genomic DNA Translation: ANJ20978.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KX154858 Genomic DNA Translation: ANJ20978.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di1.20.1310.20, 7 hits
InterProiView protein in InterPro
IPR004258, DBL
IPR042202, Duffy-ag-bd_sf
IPR008602, Duffy-antigen-binding
PfamiView protein in Pfam
PF05424, Duffy_binding, 7 hits
PF03011, PFEMP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A191VZ36_PLAFA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A191VZ36
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2016
Last sequence update: October 5, 2016
Last modified: April 22, 2020
This is version 11 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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