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Protein

RNA polymerase II transcription factor B subunit 2

Gene

PCL_03474

Organism
Purpureocillium lilacinum
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repairUniRule annotation, Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II transcription factor B subunit 2UniRule annotation
Gene namesi
ORF Names:PCL_03474Imported, VFPBJ_06939Imported, VFPFJ_02604Imported
OrganismiPurpureocillium lilacinumImported
Taxonomic identifieri33203 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesOphiocordycipitaceaePurpureocillium
Proteomesi
  • UP000078340 Componenti: Unassembled WGS sequence
  • UP000078240 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the TFB2 family.UniRule annotation

Phylogenomic databases

KOiK03144

Family and domain databases

InterProiView protein in InterPro
IPR004598 TFIIH_p52/Tfb2
PANTHERiPTHR13152 PTHR13152, 1 hit
PfamiView protein in Pfam
PF03849 Tfb2, 1 hit
TIGRFAMsiTIGR00625 tfb2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A179HU65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVSPAQSLQ LAEYLEKLPG TTFRKLYQQP STAFAIFRRM LTHLAKTFVM
60 70 80 90 100
RMLFMPKPML LSDLDNWIKP DAKRQKDQAL SILRGLHIIQ ISAPSKEKPQ
110 120 130 140 150
ELYLTANFKT SLRLALTGGG THNSFGVPSS LAVPTEIDIA FLDRYARKKW
160 170 180 190 200
EDILHFVVSS VGYKSAGESS GPNKSVKDLL VAGRLVDRRP NGSVGITQAG
210 220 230 240 250
FTFLLQEANA QVWTLLLLWL EASEINKAAG LETVDMLSFL FVLASLELGR
260 270 280 290 300
AYDTNALTEQ RKNMLPSLLD FGLIYIPQHK RSMFFPTRLA TTLTSGGNSL
310 320 330 340 350
RTISDGVAAA TSAALNPGQA GPLGGSGEQK GSVVVETNYR IYAYTQSTLQ
360 370 380 390 400
IAVLALFTKL SMRFPDMVAG RVTRASIRQA INFGITADQI ISYLAAHAHE
410 420 430 440 450
QMHRTAALTN KPVLPPTVVD QIRLWQLENE RMKTTSGFLF RDFDDHKEFL
460 470 480 490
ETARFAEEIG VLVWRGDKSG MFFASKHEQI RDYLKSRKRA E
Length:491
Mass (Da):54,696
Last modified:September 7, 2016 - v1
Checksum:i1099A46444D9965F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LSBH01000005 Genomic DNA Translation: OAQ78818.1
LSBI01000002 Genomic DNA Translation: OAQ93442.1
LCWV01000001 Genomic DNA Translation: PWI76280.1
RefSeqiXP_018182161.1, XM_018319687.1

Genome annotation databases

EnsemblFungiiOAQ78818; OAQ78818; VFPBJ_06939
OAQ93442; OAQ93442; VFPFJ_02604
GeneIDi28884736
KEGGiplj:VFPFJ_02604

Similar proteinsi

Entry informationi

Entry nameiA0A179HU65_9HYPO
AccessioniPrimary (citable) accession number: A0A179HU65
Entry historyiIntegrated into UniProtKB/TrEMBL: September 7, 2016
Last sequence update: September 7, 2016
Last modified: July 18, 2018
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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