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Entry version 18 (03 Jul 2019)
Sequence version 1 (07 Sep 2016)
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Protein

ABC multidrug transporter lscH

Gene

lcsH

Organism
Purpureocillium lilacinum (Paecilomyces lilacinus)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ABC multidrug transporter; part of the gene cluster that mediates the biosynthesis of the lipopeptide antibiotics leucinostatins that show extensive biological activities, including antimalarial, antiviral, antibacterial, antifungal, and antitumor activities, as well as phytotoxic (PubMed:27416025). May be involved in the efflux of leucinostatins (Probable).1 Publication1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi676 – 683ATPPROSITE-ProRule annotation8
Nucleotide bindingi1328 – 1335ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ABC multidrug transporter lscH1 Publication
Alternative name(s):
Leucinostatins biosynthesis cluster protein H1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lcsH1 Publication
ORF Names:VFPBJ_02522
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPurpureocillium lilacinum (Paecilomyces lilacinus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri33203 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesOphiocordycipitaceaePurpureocillium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000078240 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei32 – 52HelicalSequence analysisAdd BLAST21
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei280 – 300HelicalSequence analysisAdd BLAST21
Transmembranei311 – 331HelicalSequence analysisAdd BLAST21
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Transmembranei457 – 477HelicalSequence analysisAdd BLAST21
Transmembranei500 – 520HelicalSequence analysisAdd BLAST21
Transmembranei528 – 548HelicalSequence analysisAdd BLAST21
Transmembranei957 – 977HelicalSequence analysisAdd BLAST21
Transmembranei1005 – 1025HelicalSequence analysisAdd BLAST21
Transmembranei1076 – 1096HelicalSequence analysisAdd BLAST21
Transmembranei1100 – 1120HelicalSequence analysisAdd BLAST21
Transmembranei1184 – 1204HelicalSequence analysisAdd BLAST21
Transmembranei1210 – 1230HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004466111 – 1552ABC multidrug transporter lscHAdd BLAST1552

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi91N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi592N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi719N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi834N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1028N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1299N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1313N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is positively regulated by the leucinostatins biosynthesis cluster-specific transcription regulator lcsF.1 Publication

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini280 – 559ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST280
Domaini639 – 884ABC transporter 1PROSITE-ProRule annotationAdd BLAST246
Domaini963 – 1241ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST279
Domaini1295 – 1538ABC transporter 2PROSITE-ProRule annotationAdd BLAST244

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A179H0T5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAEAACSDD SFGPWAGATC RGGFDFTLLF EETILSILPS VLVIVVAPIP
60 70 80 90 100
IIRLAREPPK VRASALDWFK KISSICFITL SAALVGLWAR NSTITQTRAS
110 120 130 140 150
TPSAVLTFVL SLVYVLLSTI EHRLSLRPSS VLSFYLGLSV LFDIARTRTL
160 170 180 190 200
FMLEDATHSA IPPVFASSLA LRVVMLLLES TEKRSLLLAK YDNAAPESVG
210 220 230 240 250
GPYNLGVFYW LSTLFFTGYR KILEIGDLYP LDDELRSTGL AKKMSDAWRK
260 270 280 290 300
VPDKAAPNVL FATWLKTFSK AMFMPVVPRL FQIGFTYAQP FLITAAIELA
310 320 330 340 350
ATPQTQPYNN NGYGLIGAYI LVYSGIAVSV GQYEWRNYRA ATMMRGSIIP
360 370 380 390 400
LVYEKSLILD SCSSATFHPT AALTLVSTDI ETITSGLVQI HETWSNLVEI
410 420 430 440 450
GLAIYLLERQ LGAACVMSVG FAIVVMVGTV FLARPTGTHL AAWIQASQVR
460 470 480 490 500
VIETSKALAS IKWLKISGLT DVAFSVIQKL RKQELVVSEK FRYLLGLSLI
510 520 530 540 550
LSICTPILGP LLTFAVFAGI AAHGGSTLTI AKVFTAFSII VLLNSPLAKI
560 570 580 590 600
VQALPQISGS IASFQRIQDH LNAEERHDPR STTTGTSPES NNGSQQTLSD
610 620 630 640 650
KQATADGDTM ISISGKFSWR SETPAPGTGI TLVTGSDEGH LADTTPDANG
660 670 680 690 700
DSRDAPVIDI SPRLDIPRGA LTLILGPVGC GKSTLLKALL GELSSFDGVI
710 720 730 740 750
EAKYSGAVTY CDQNPWLPNE TVRDIIRGRS ATDTSDADSS EKADHDEDWY
760 770 780 790 800
RVVVSACELQ RDMQIWPRGD RTPVGSKGIS MSGGQKQRLS IARAVYARRA
810 820 830 840 850
LVILDDVFSG LDANTEDVVF ENLLGNSGIL RKANMTVVLA SSDVRRVPFA
860 870 880 890 900
DKIVLLNQHG QVQHTGTPGD LKQVAELGWA DRDLDAQQEK PGKDELNHEH
910 920 930 940 950
GEYSESAPEK LRRSQTNHGA DNNAAVQEVL QAVESQADTA RQMGDSAVYK
960 970 980 990 1000
FYVKSAGWLT ITIFVIAICV YAFCDSFPSV WLKWWAEANE KNPNSDLGKW
1010 1020 1030 1040 1050
LGVYAVLGVG AVAACLIGTW QLFIITINRS GLYFHNLLVE TVSRAPMMFH
1060 1070 1080 1090 1100
STTDTGITVN RFSQDLQLID MELPSAALGV VMALSFGIAQ FILVCVSSRY
1110 1120 1130 1140 1150
MAALLPFLLA VLYAIQHFYL RTARQLRLLD IEYKAPLYTQ LMETISGVVT
1160 1170 1180 1190 1200
IRAFRWETQS TEKAIRILDT SQKPSYLLFC VQRWITFAVN MVIMMLAVIL
1210 1220 1230 1240 1250
IVLTTTLREA IGPGYVGIAL SNILAFSATM QATITSWVTL EIALGAVARI
1260 1270 1280 1290 1300
RSFSMQVRSE DDEARDGLAK AGLDARLVQP TPETVGERWP SQGRIELDNV
1310 1320 1330 1340 1350
TASYPSSGRV LHNITMIIEP GQKVAICGRT GSGKSSLFLS LLGLIAQDSG
1360 1370 1380 1390 1400
SITIDSVDLA TLPREYLRSQ IVAVPQEAYI LDGTVRLNAD PYHNKETLGS
1410 1420 1430 1440 1450
TDPPDSRDEQ IIDVLKRVGL WEKIATRGGL DMVIDDKFLS QGQAQLMVLA
1460 1470 1480 1490 1500
RAMLRRDESR VLLLDEATSS LDEATTTLID EIVSTWFKDW TVLAIAHKLD
1510 1520 1530 1540 1550
AILDYDRVAV LDAGRLVEYD QPRELLQRPT SIFKELYLLS TNQASLSSPD

SN
Length:1,552
Mass (Da):169,897
Last modified:September 7, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8158CA8D944E9859
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LSBH01000002 Genomic DNA Translation: OAQ83754.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
OAQ83754; OAQ83754; VFPBJ_02522

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LSBH01000002 Genomic DNA Translation: OAQ83754.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblFungiiOAQ83754; OAQ83754; VFPBJ_02522

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 1 hit
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLCSH_PURLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A179H0T5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 10, 2019
Last sequence update: September 7, 2016
Last modified: July 3, 2019
This is version 18 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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