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Entry version 20 (31 Jul 2019)
Sequence version 1 (07 Sep 2016)
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Protein
Submitted name:

ATPI4K ALPHA

Gene

AXX17_At1g43500

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinasePROSITE-ProRule annotationSAAS annotation, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
ATPI4K ALPHAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Ordered Locus Names:AXX17_At1g43500Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000078284 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A178WHK0 baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1483 – 1659PIK helicalInterPro annotationAdd BLAST177
Domaini1767 – 2009PI3K/PI4KInterPro annotationAdd BLAST243

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni184 – 241DisorderedSequence analysisAdd BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili483 – 503Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi186 – 219PolarSequence analysisAdd BLAST34

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1070.11, 1 hit
1.25.40.70, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR001263 PI3K_accessory_dom
IPR042236 PI3K_accessory_sf
IPR015433 PI_Kinase

The PANTHER Classification System

More...
PANTHERi
PTHR10048 PTHR10048, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00454 PI3_PI4_kinase, 2 hits
PF00613 PI3Ka, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 3 hits
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51545 PIK_HELICAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A178WHK0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEALTELCDI IAKNPKQFSE KLAWICGRCP QTEWLLAESP RVSRSHLNAV
60 70 80 90 100
LAVARIISKN PESIDNRAKS VVNEFLSAIP ASFRRSFWPH SFPSQLISSF
110 120 130 140 150
YCDFLSYLSC AADLSPEFGT EVARFTGEVV IAAIAPSSGD SDGDPAISKA
160 170 180 190 200
FLVALSQHFP SILQSDGDKL ITMLLDQFVL NRAPASPKEQ RQQNSANSET
210 220 230 240 250
DTSSSQGSPV STNRYPSGKT EMASPGDEVA SHGSNLSSKS SSSVVMNGGS
260 270 280 290 300
IVWKSGVDQL SFGFSEGSGG ANPVFRQQVA SFEDESIESL EKQEIAFRLI
310 320 330 340 350
THILDKVKID SKLQDQVRFI AKRQLQSMSA FLKSRKRDWN EQGQVLKTRV
360 370 380 390 400
NAKLSVYQAA AKMKIKSLVS LETDGKTSKR LVLETLALLL DAADACLTSV
410 420 430 440 450
WRKMKACEEL FDSLLSGIAK IAVARGGQPL RVLLIRLKPL VLAVCALPDQ
460 470 480 490 500
GAMLESIFKT SCEIIESAWA KDRAPVDNFI MGLASSIRER NDYEEQVDRE
510 520 530 540 550
KQVPAVQLNV IRLLADLNVA VKKPEVADMI LPLFIESLEE GDASTPSFLR
560 570 580 590 600
LQLLDAVSRI ATLGFDKSYR ETVVLMTRSY LSKLSSVGSV ESKTSAPEAT
610 620 630 640 650
TERVETLPAG FLTIASGLMD TKLRSDYRHR LLSLCSDVGL AAESKSGGSG
660 670 680 690 700
VDFLGPLLPA VAEICSDFDP TMDVEPSLLK LFRNLWFYIA LFGLAPPIVK
710 720 730 740 750
TPTPPLKSTS NSVNSVGSMS ATALQAVGGP YMWDNQWALA VQRIAQGTPP
760 770 780 790 800
LVVSSVKWLE DELELNALHN PGSRRGNGNE KVASTQRLAL STALGGRVDV
810 820 830 840 850
AAMNTISGVK ATYLLAVAFL EIIRFISNGG ILNGESSVSA SRSAFSCVFE
860 870 880 890 900
YLKTPNLTPA VSQCLTAIVH RAFETAVSWL EDRISLTGKD ARNRELTTYA
910 920 930 940 950
HACFLIKSMS QRDEHVRDIS VNLLTQLRDK FPQVLWHSSC LDSLLFSVHD
960 970 980 990 1000
NTPSTVVNDP AWTAAVRSLY QKVVREWIII SLSYAPCTSQ GLLQDKLCKA
1010 1020 1030 1040 1050
NTWQRAQTTT DVVSLLSEIK IGTGKNELWS GIRTANIPAV MAAAAAASGA
1060 1070 1080 1090 1100
NLKVSEAFNL EVLGTGVVSA TVKCNHAGEI AGMRRLYNSI GGFQSGSTPS
1110 1120 1130 1140 1150
GFGGGLQRLI SGAFSQAPQP EDDSFNEMLI ARFVRLLQQF VNTAEKGGEV
1160 1170 1180 1190 1200
EKSQFRETCS QATALLLSNL GGESKTNVEG FSQLLRLLCW CPAYISTPDA
1210 1220 1230 1240 1250
METGIFIWTW LVSAAPQLVS LVLAELVDAW IWTIDTKRGL FASDVRYSGP
1260 1270 1280 1290 1300
AAKLRPHLSP GEPEDPPESD PVDQIVAHRL WLGFLIDRFE VVRHNSAEQL
1310 1320 1330 1340 1350
LLLGRMLQRS TDLEWCFTRH PAAAGTFFSL MLLGLKFCSC QTQGNMQKFR
1360 1370 1380 1390 1400
SGLQLLEDRI YRTSLGWFAH QPEWYDVNIP NFCHSEALSV SVFVHFLSNE
1410 1420 1430 1440 1450
LSESSQSDSK GKPRESGNLI DVTDQYHPVW GEMDNYTLGK EKRKQLLLML
1460 1470 1480 1490 1500
CQHEADRLDV WAQPISSKDS PYSRLKISSE KWTEYAKTAF SVDPRIALSV
1510 1520 1530 1540 1550
ASRFPANASV KSEVTQLVQT NIVDLRTIPE ALPYFVTPKN VEENSVLLQQ
1560 1570 1580 1590 1600
LPHWAACSIT QALEFLTPAY KGHPRVMAYV LRVLESYPPE RVTFFMPQLV
1610 1620 1630 1640 1650
QSLRYDDGRL VEGYLLRATQ RSDIFAHILI WHLQGEDVQE TPKDGSIDKN
1660 1670 1680 1690 1700
AAFQEILPQV RQHIIDGFSP NALDMFTREF DFFDKVTSIS GVLFPLPKEE
1710 1720 1730 1740 1750
RRAGIRRELE KIEMQGDDLY LPTAPNKLVR GIRVDSGIPL QSAAKVPIMI
1760 1770 1780 1790 1800
TFNVIDRDGD HSDVKPQACI FKVGDDCRQD VLALQVISLL RDIFQAAGLN
1810 1820 1830 1840 1850
LYLFPYGVLP TGAERGIIEV VPNTRSRSQM GETTDGGLYE IFQQDYGPVG
1860 1870 1880 1890 1900
STTFETAREN FLISSAGYAV ASLLLQPKDR HNGNLLFDDV GRLVHIDFGF
1910 1920 1930 1940 1950
ILETSPGGNM RFESAHFKLS HEMTQLLDPS GVMKSKTWHQ FVSLCVKGYL
1960 1970 1980 1990 2000
AARRQMDGII STVQMMLESG LPCFSRGDPI GNLRKRFHPE MSEREAAHFM
2010 2020
IHVCTDAYNK WTTAGYDLIQ YLQQGIEK
Length:2,028
Mass (Da):224,033
Last modified:September 7, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2DFF4EAC176108B7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
LUHQ01000001 Genomic DNA Translation: OAP17726.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LUHQ01000001 Genomic DNA Translation: OAP17726.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Gene expression databases

ExpressionAtlasiA0A178WHK0 baseline and differential

Family and domain databases

Gene3Di1.10.1070.11, 1 hit
1.25.40.70, 1 hit
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR011009 Kinase-like_dom_sf
IPR000403 PI3/4_kinase_cat_dom
IPR036940 PI3/4_kinase_cat_sf
IPR018936 PI3/4_kinase_CS
IPR001263 PI3K_accessory_dom
IPR042236 PI3K_accessory_sf
IPR015433 PI_Kinase
PANTHERiPTHR10048 PTHR10048, 1 hit
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 2 hits
PF00613 PI3Ka, 1 hit
SMARTiView protein in SMART
SM00145 PI3Ka, 1 hit
SM00146 PI3Kc, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00915 PI3_4_KINASE_1, 1 hit
PS50290 PI3_4_KINASE_3, 1 hit
PS51545 PIK_HELICAL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A178WHK0_ARATH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A178WHK0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 7, 2016
Last sequence update: September 7, 2016
Last modified: July 31, 2019
This is version 20 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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