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Protein

Pyruvate kinase

Gene

AXX17_ATUG04870

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 5 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic (GAPC2), Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic (GAPC1)
  2. Phosphoglycerate kinase 3, cytosolic (PGK3)
  3. Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2 (At3g08590), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1 (PGM1)
  4. Enolase 1, chloroplastic (ENO1), Cytosolic enolase 3 (ENO3), Bifunctional enolase 2/transcriptional activator (ENO2)
  5. Pyruvate kinase (AXX17_At5g51800), Pyruvate kinase (AXX17_At3g24740), Pyruvate kinase (AXX17_At5g63250), Pyruvate kinase (AXX17_At3g50280), Pyruvate kinase (AXX17_ATUG04870), Pyruvate kinase (MAH20.13), Pyruvate kinase (MCD7.8), Pyruvate kinase (MBK5.16), Pyruvate kinase (F1I16_60), Pyruvate kinase (At3g25960), Pyruvate kinase (AXX17_At3g50440), Plastidial pyruvate kinase 3, chloroplastic (PKP3), Pyruvate kinase (At3g52990), Pyruvate kinase (AXX17_At5g08490), Pyruvate kinase (AXX17_At5g55530), Pyruvate kinase (AXX17_At3g28070), Pyruvate kinase (At2g36580), Pyruvate kinase (AXX17_At3g47400), Pyruvate kinase, Probable pyruvate kinase, cytosolic isozyme (At4g26390), Pyruvate kinase (F8J2_160), Pyruvate kinase (At3g52990), Pyruvate kinase (AXX17_At3g03460), Plastidial pyruvate kinase 2 (PKP2), Pyruvate kinase (AXX17_At2g33300), Pyruvate kinase (At3g04050), Pyruvate kinase (AXX17_At4g30430), Pyruvate kinase (F1I16_220), Plastidial pyruvate kinase 1, chloroplastic (PKP1), Pyruvate kinase (AXX17_At1g33230), Pyruvate kinase (At5g63680), Pyruvate kinase, Plastidial pyruvate kinase 4, chloroplastic (PKP4)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotation, Transferase
Biological processGlycolysisUniRule annotation
LigandMagnesiumUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinaseUniRule annotation (EC:2.7.1.40UniRule annotation)
Gene namesi
ORF Names:AXX17_ATUG04870Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000078284 Componenti: Unassembled WGS sequence

Expressioni

Gene expression databases

ExpressionAtlasiA0A178U603 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 319PKInterPro annotationAdd BLAST319
Domaini335 – 436PK_CInterPro annotationAdd BLAST102
Domaini479 – 807Lyase_1InterPro annotationAdd BLAST329
Domaini873 – 925FumaraseC_CInterPro annotationAdd BLAST53

Sequence similaritiesi

Belongs to the pyruvate kinase family.UniRule annotation

Family and domain databases

Gene3Di1.10.275.10, 1 hit
2.40.33.10, 1 hit
3.40.1380.20, 1 hit
InterProiView protein in InterPro
IPR024083 Fumarase/histidase_N
IPR018951 Fumarase_C_C
IPR020557 Fumarate_lyase_CS
IPR022761 Fumarate_lyase_N
IPR008948 L-Aspartase-like
IPR001697 Pyr_Knase
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
IPR011037 Pyrv_Knase-like_insert_dom_sf
IPR018209 Pyrv_Knase_AS
IPR015793 Pyrv_Knase_brl
IPR015795 Pyrv_Knase_C
IPR036918 Pyrv_Knase_C_sf
IPR015806 Pyrv_Knase_insert_dom_sf
PfamiView protein in Pfam
PF10415 FumaraseC_C, 1 hit
PF00206 Lyase_1, 1 hit
PF00224 PK, 1 hit
PF02887 PK_C, 1 hit
PRINTSiPR01050 PYRUVTKNASE
SUPFAMiSSF48557 SSF48557, 1 hit
SSF50800 SSF50800, 1 hit
SSF51621 SSF51621, 2 hits
SSF52935 SSF52935, 1 hit
TIGRFAMsiTIGR01064 pyruv_kin, 1 hit
PROSITEiView protein in PROSITE
PS00163 FUMARATE_LYASES, 1 hit
PS00110 PYRUVATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A178U603-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIGAGMNVAR LNMAHGELQD HGDRITRIRQ AAGELNALVP ILMDIKGPEV
60 70 80 90 100
RIGKLAEPGE LKAGEKLTLT TEIIVGDTRR ISVNYANLPS DVKPGNRILI
110 120 130 140 150
DDGLIELTVD SVTDTEIECV IVNGGMIKSN KGVNLPGIHT SLPGVTERDI
160 170 180 190 200
MHIKYGVEQK VDIIAPSFVR RAEDIWQIRG MLEELGAPHI QIISKIENQE
210 220 230 240 250
GVTNLDSIIE ASDGIMVARG DLGVEIPVEE VPMIQREMIE KCNRAGKPVI
260 270 280 290 300
VATHMLDSMQ VNPRPTRAEV SDVANAVIQG TDSVMLSGET AAGKYPVESI
310 320 330 340 350
ATMANIAIKA ESMLDYTEQF KKRSQVQPAT TTEIISQAVV SSSLELGAKA
360 370 380 390 400
ILTPTESGFT ARMVSKYRPK APVIAIAYDD NVLMRLCLLW GVIPVRGEKE
410 420 430 440 450
ESTDAVFASA VHNGRKTGLL TSGDHVVISA GTPIGKAEWE QEDGLCWREL
460 470 480 490 500
VRLAVCLYEL DARRIPQVSY RIEKDFLGDK EVPLEAYYGV QTIRALENFP
510 520 530 540 550
ITGIPVHFEL FSALAKVKKA AARANAATHM LPQPIADAIV QAADEVAGGM
560 570 580 590 600
LADQFIVDSI QGGAGTSINM NMNEVLANRA LEIMGHAKGE YFYCNPNNHV
610 620 630 640 650
NMAQSTNDAV PTALKIAAYQ LAHRLLDTLA YLHEAFLAKA AAFDDVIKMG
660 670 680 690 700
RTHLQDAVPI RLGQEFGAYA AVIGRDRKRI ASATAHLLAV NLGATAVGTG
710 720 730 740 750
LNAKPEYIAE VVRLLAEDLN IPLVSAEDLV DATQNTDAYT ELSAALKVCA
760 770 780 790 800
VNLSKICNDI RMMASGPRTG LSELALPPRQ PGSSIMPGKV NPVMAEVVNQ
810 820 830 840 850
TAFQVMGNDH TICLASEAGQ FELNVMGPVI ALNLLQSLKI LRNAVDVFVR
860 870 880 890 900
FAIEGLEANR ERGQSYVKNS FGIVTALNPH LGYEVAAGLV KEALRTGLSI
910 920 930 940
QELILERHLL SKEEMDIILD PMQMTTPGIA GEWLIGRDGE Q
Length:941
Mass (Da):101,792
Last modified:September 7, 2016 - v1
Checksum:i7FA7B47BE7E507BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LUHQ01000028 Genomic DNA Translation: OAO89069.1

Entry informationi

Entry nameiA0A178U603_ARATH
AccessioniPrimary (citable) accession number: A0A178U603
Entry historyiIntegrated into UniProtKB/TrEMBL: September 7, 2016
Last sequence update: September 7, 2016
Last modified: February 28, 2018
This is version 10 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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