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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Anoxybacillus flavithermus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei64Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processDNA damage, DNA repairUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotation
ORF Names:CA592_10105Imported, TAF16_0041Imported
OrganismiAnoxybacillus flavithermusImported
Taxonomic identifieri33934 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeAnoxybacillus
Proteomesi
  • UP000196782 Componenti: Chromosome
  • UP000078336 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 209UDGInterPro annotationAdd BLAST161

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A178TDK2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSILKNDWAP LLEEEFQKPY YLKLRQFLKE EYRTKTIYPD MHDIFNALHY
60 70 80 90 100
TPYADVKVVI LGQDPYHGPN QAHGLSFSVK PGVALPPSLL NIFKELHDDL
110 120 130 140 150
GCYIPNNGYL LKWAKQGVLL LNTVLTVRQG EANSHKGKGW EHFTDRIIEL
160 170 180 190 200
VNEKTEPVVF ILWGRHAQAK KALITNEHHY LIEAPHPSPL SAARGFFGSR
210 220
PFSKTNAFLQ RTGRETIDWQ IENI
Length:224
Mass (Da):25,789
Last modified:September 7, 2016 - v1
Checksum:iE598830BA5DCB018
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP021838 Genomic DNA Translation: ASA97130.1
LUCQ01000005 Genomic DNA Translation: OAO83230.1
RefSeqiWP_004893137.1, NZ_LUFB01000118.1

Genome annotation databases

EnsemblBacteriaiOAO83230; OAO83230; TAF16_0041
PATRICifig|33934.6.peg.2825

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP021838 Genomic DNA Translation: ASA97130.1
LUCQ01000005 Genomic DNA Translation: OAO83230.1
RefSeqiWP_004893137.1, NZ_LUFB01000118.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiOAO83230; OAO83230; TAF16_0041
PATRICifig|33934.6.peg.2825

Family and domain databases

CDDicd10027 UDG_F1, 1 hit
Gene3Di3.40.470.10, 1 hit
HAMAPiMF_00148 UDG, 1 hit
InterProiView protein in InterPro
IPR002043 UDG_fam1
IPR018085 Ura-DNA_Glyclase_AS
IPR005122 Uracil-DNA_glycosylase-like
IPR036895 Uracil-DNA_glycosylase-like_sf
PANTHERiPTHR11264 PTHR11264, 1 hit
PfamiView protein in Pfam
PF03167 UDG, 1 hit
SMARTiView protein in SMART
SM00986 UDG, 1 hit
SUPFAMiSSF52141 SSF52141, 1 hit
TIGRFAMsiTIGR00628 ung, 1 hit
PROSITEiView protein in PROSITE
PS00130 U_DNA_GLYCOSYLASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A178TDK2_9BACI
AccessioniPrimary (citable) accession number: A0A178TDK2
Entry historyiIntegrated into UniProtKB/TrEMBL: September 7, 2016
Last sequence update: September 7, 2016
Last modified: November 7, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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