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UniProtKB - A0A177YEB0 (A0A177YEB0_PSEPU)

Entry version 14 (08 May 2019)
Sequence version 1 (07 Sep 2016)
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Protein

Probable 5-dehydro-4-deoxyglucarate dehydratase

Gene

mosA

Organism
Pseudomonas putida (Arthrobacter siderocapsulatus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: D-glucarate degradation

This protein is involved in step 2 of the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate.UniRule annotationSAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glucarate dehydratase (gudD)
  2. Probable 5-dehydro-4-deoxyglucarate dehydratase (HA62_06375), Probable 5-dehydro-4-deoxyglucarate dehydratase (DW66_3364), Probable 5-dehydro-4-deoxyglucarate dehydratase (kdgD), Probable 5-dehydro-4-deoxyglucarate dehydratase (AO269_10510), Probable 5-dehydro-4-deoxyglucarate dehydratase (BGP84_13810), Probable 5-dehydro-4-deoxyglucarate dehydratase (kdgD), Probable 5-dehydro-4-deoxyglucarate dehydratase (A3L25_25870), Probable 5-dehydro-4-deoxyglucarate dehydratase (kdgD), Probable 5-dehydro-4-deoxyglucarate dehydratase (kdgD), Probable 5-dehydro-4-deoxyglucarate dehydratase (kdgD), Probable 5-dehydro-4-deoxyglucarate dehydratase (PSEMO_05320), Probable 5-dehydro-4-deoxyglucarate dehydratase (kdgD), Probable 5-dehydro-4-deoxyglucarate dehydratase (AYO28_18420), Probable 5-dehydro-4-deoxyglucarate dehydratase (kdgD), Probable 5-dehydro-4-deoxyglucarate dehydratase (SAMN03097715_05359), Probable 5-dehydro-4-deoxyglucarate dehydratase (HB4184_13805), Probable 5-dehydro-4-deoxyglucarate dehydratase (kdgD), Probable 5-dehydro-4-deoxyglucarate dehydratase (KF715C_ch30880), Probable 5-dehydro-4-deoxyglucarate dehydratase (BGP80_16365), Probable 5-dehydro-4-deoxyglucarate dehydratase (BL240_12265), Probable 5-dehydro-4-deoxyglucarate dehydratase (B7H18_17750), Probable 5-dehydro-4-deoxyglucarate dehydratase (kdgD), Probable 5-dehydro-4-deoxyglucarate dehydratase (BIW19_13625), 5-dehydro-4-deoxyglucarate dehydratase, Probable 5-dehydro-4-deoxyglucarate dehydratase (kdgD), Probable 5-dehydro-4-deoxyglucarate dehydratase (kdgD), Probable 5-dehydro-4-deoxyglucarate dehydratase (CBL13_00668), Probable 5-dehydro-4-deoxyglucarate dehydratase (mosA), Probable 5-dehydro-4-deoxyglucarate dehydratase (B8W72_02700), Probable 5-dehydro-4-deoxyglucarate dehydratase (mosA), Probable 5-dehydro-4-deoxyglucarate dehydratase (kdgD), Probable 5-dehydro-4-deoxyglucarate dehydratase (HB13667_24465)
This subpathway is part of the pathway D-glucarate degradation, which is itself part of Carbohydrate acid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2,5-dioxopentanoate from D-glucarate, the pathway D-glucarate degradation and in Carbohydrate acid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00564;UER00628

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable 5-dehydro-4-deoxyglucarate dehydrataseUniRule annotation (EC:4.2.1.41UniRule annotation)
Alternative name(s):
5-keto-4-deoxy-glucarate dehydrataseUniRule annotation
Short name:
KDGDHUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mosAImported
ORF Names:A3K88_25680Imported, NCTC912_02777Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPseudomonas putida (Arthrobacter siderocapsulatus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri303 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000077741 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000255432 Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DapA family.UniRule annotationSAAS annotation

Family and domain databases

Conserved Domains Database

More...CDDi		cd00951 KDGDH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.20.20.70, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_00694 KDGDH, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013785 Aldolase_TIM
IPR002220 DapA-like
IPR017655 Dehydro-deoxyglucarate_dehyd

The PANTHER Classification System

More...PANTHERi		PTHR12128 PTHR12128, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00701 DHDPS, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001365 DHDPS, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01130 DHDPS, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR03249 KdgD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A177YEB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPQELKSIL SHGLLSFPVT DFNAQGDFNP AGYIKRLEWL APYGASALFA 
        60         70         80         90        100
AGGTGEFFSL AASEYSQVIK TAVDTCATSV PILAGVGGST RQAIEYAQEA 
       110        120        130        140        150
ERLGAKGLLL LPHYLTEASQ DGVAAHVEAV CKSVKIGVVV YNRNVCRLNA 
       160        170        180        190        200
NLLEKLAERC PNLIGYKDGL GDIELMVSIR RRLGDRFSYL GGLPTAEVYA 
       210        220        230        240        250
AAYKALGVPV YSSAVFNFVP KTAMDFYNAI ARDDHAAVAK LIDDFFLPYL 
       260        270        280        290        300
DIRNRKAGYA VSIVKAGAKL AGYDAGPVRT PLTDLTAEEY EMLAALMDKM 

GPQ
Length:303
Mass (Da):32,602
Last modified:September 7, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3EAA42F78190F024
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
LVHH01000084 Genomic DNA Translation: OAK53670.1
UGUZ01000001 Genomic DNA Translation: SUD78708.1

NCBI Reference Sequences

More...RefSeqi		WP_009687018.1, NZ_UGUZ01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		OAK53670; OAK53670; A3K88_25680

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LVHH01000084 Genomic DNA Translation: OAK53670.1
UGUZ01000001 Genomic DNA Translation: SUD78708.1
RefSeqiWP_009687018.1, NZ_UGUZ01000001.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiOAK53670; OAK53670; A3K88_25680

Enzyme and pathway databases

UniPathwayiUPA00564;UER00628

Family and domain databases

CDDicd00951 KDGDH, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00694 KDGDH, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR002220 DapA-like
IPR017655 Dehydro-deoxyglucarate_dehyd
PANTHERiPTHR12128 PTHR12128, 1 hit
PfamiView protein in Pfam
PF00701 DHDPS, 1 hit
PIRSFiPIRSF001365 DHDPS, 1 hit
SMARTiView protein in SMART
SM01130 DHDPS, 1 hit
TIGRFAMsiTIGR03249 KdgD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A177YEB0_PSEPU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A177YEB0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 7, 2016
Last sequence update: September 7, 2016
Last modified: May 8, 2019
This is version 14 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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