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Protein

Aspartate-semialdehyde dehydrogenase

Gene

asd

Organism
Aureimonas ureilytica
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

L-aspartate 4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH.UniRule annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 2 of the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Aspartokinase (NS226_23815), Aspartokinase (NS226_10030)
  2. Aspartate-semialdehyde dehydrogenase (asd), Aspartate-semialdehyde dehydrogenase (asd)
  3. 4-hydroxy-tetrahydrodipicolinate synthase (dapA), 4-hydroxy-tetrahydrodipicolinate synthase (dapA)
  4. 4-hydroxy-tetrahydrodipicolinate reductase (dapB), 4-hydroxy-tetrahydrodipicolinate reductase (dapB)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-tetrahydrodipicolinate from L-aspartate, the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes L-homoserine from L-aspartate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Aspartokinase (NS226_23815), Aspartokinase (NS226_10030)
  2. Aspartate-semialdehyde dehydrogenase (asd), Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (NS226_13195), Homoserine dehydrogenase (NS365_20320)
This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homoserine from L-aspartate, the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

Pathwayi: L-threonine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-threonine from L-aspartate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Aspartokinase (NS226_23815), Aspartokinase (NS226_10030)
  2. Aspartate-semialdehyde dehydrogenase (asd), Aspartate-semialdehyde dehydrogenase (asd)
  3. Homoserine dehydrogenase (NS226_13195), Homoserine dehydrogenase (NS365_20320)
  4. Homoserine kinase (thrB), Homoserine kinase (thrB)
  5. no protein annotated in this organism
This subpathway is part of the pathway L-threonine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-threonine from L-aspartate, the pathway L-threonine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99PhosphateUniRule annotation1
Active sitei130Acyl-thioester intermediateUniRule annotation1
Binding sitei157SubstrateUniRule annotation1
Binding sitei182NADP; via carbonyl oxygenUniRule annotation1
Binding sitei235SubstrateUniRule annotation1
Active sitei242Proton acceptorUniRule annotation1
Binding sitei315NADPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 14NADPUniRule annotation4
Nucleotide bindingi39 – 40NADPUniRule annotation2
Nucleotide bindingi160 – 161NADPUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processAmino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotation, Lysine biosynthesisUniRule annotation, Methionine biosynthesisUniRule annotation, Threonine biosynthesisUniRule annotation
LigandNADPUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00034; UER00016
UPA00050; UER00463
UPA00051; UER00464

Names & Taxonomyi

Protein namesi
Recommended name:
Aspartate-semialdehyde dehydrogenaseUniRule annotation (EC:1.2.1.11UniRule annotation)
Short name:
ASA dehydrogenaseUniRule annotation
Short name:
ASADHUniRule annotation
Alternative name(s):
Aspartate-beta-semialdehyde dehydrogenaseUniRule annotation
Gene namesi
Name:asdUniRule annotation
ORF Names:NS365_20470Imported
OrganismiAureimonas ureilyticaImported
Taxonomic identifieri401562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesAurantimonadaceaeAureimonas
Proteomesi
  • UP000078529 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Interactioni

Subunit structurei

Homodimer.UniRule annotation

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 119Semialdhyde_dhInterPro annotationAdd BLAST116

Sequence similaritiesi

Belongs to the aspartate-semialdehyde dehydrogenase family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_02121 ASADH, 1 hit
InterProiView protein in InterPro
IPR012080 Asp_semialdehyde_DH
IPR005986 Asp_semialdehyde_DH_beta
IPR036291 NAD(P)-bd_dom_sf
IPR000534 Semialdehyde_DH_NAD-bd
IPR012280 Semialdhyde_DH_dimer_dom
PfamiView protein in Pfam
PF01118 Semialdhyde_dh, 1 hit
PF02774 Semialdhyde_dhC, 1 hit
SMARTiView protein in SMART
SM00859 Semialdhyde_dh, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01296 asd_B, 1 hit

Sequencei

Sequence statusi: Complete.

A0A175RG56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGYKVAVVGA TGNVGREMLN ILDERGFPAD EVVALASRRS QGTEVSFGDK
60 70 80 90 100
TLKVKALELF DFSDVDICLM SAGGSVAKEW APKIGAQGCV VIDNSSAFRY
110 120 130 140 150
DADVPLIVPE VNADAVSGFT QRYIIANPNC STAQLVVALK PLHDKAKIKR
160 170 180 190 200
VVVSTYQSVS GAGKEGMDEL FEQSRAVFVA DPVTAKKFTK RIAFNVIPHI
210 220 230 240 250
DVFMEDGTTK EEWKVMAETK KMLDPKIKVT CTAVRVPVFI GHSESVNIEF
260 270 280 290 300
ENPITADEAR EILREAPGCL VIDKHEDGAY ATPIDTAGED ATYISRIRED
310 320 330 340
QTLENGLNMW VVADNLRKGA ALNAIQIAEL LVNRRLLGAK KAA
Length:343
Mass (Da):37,290
Last modified:September 7, 2016 - v1
Checksum:i0350C75290435A1F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LDQA01000067 Genomic DNA Translation: KTR02760.1
RefSeqiWP_058602143.1, NZ_LDQA01000067.1

Genome annotation databases

EnsemblBacteriaiKTR02760; KTR02760; NS365_20470
PATRICifig|401562.4.peg.4121

Similar proteinsi

Entry informationi

Entry nameiA0A175RG56_9RHIZ
AccessioniPrimary (citable) accession number: A0A175RG56
Entry historyiIntegrated into UniProtKB/TrEMBL: September 7, 2016
Last sequence update: September 7, 2016
Last modified: May 23, 2018
This is version 10 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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