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Entry version 22 (08 May 2019)
Sequence version 1 (07 Sep 2016)
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Protein

NADH-quinone oxidoreductase subunit I

Gene

ndhI

Organism
Arabidopsis lyrata subsp. petraea (Northern rock-cress) (Cardaminopsis petraea)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

NDH shuttles electrons from NAD(P)H:plastoquinone, via FMN and iron-sulfur (Fe-S) centers, to quinones in the photosynthetic chain and possibly in a chloroplast respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient.SAAS annotation
NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterUniRule annotationNote: Binds 2 [4Fe-4S] clusters per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi64Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi67Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi70Iron-sulfur 1 (4Fe-4S)UniRule annotation1
Metal bindingi74Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi104Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi107Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi110Iron-sulfur 2 (4Fe-4S)UniRule annotation1
Metal bindingi114Iron-sulfur 1 (4Fe-4S)UniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocaseUniRule annotationSAAS annotation
Ligand4Fe-4SUniRule annotationSAAS annotation, Iron, Iron-sulfur, Metal-binding, NADUniRule annotationSAAS annotation, NADPSAAS annotation, PlastoquinoneSAAS annotation, UbiquinoneUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit IUniRule annotation (EC:7.1.1.-UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit IUniRule annotation
NDH-1 subunit IUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ndhIImported
Synonyms:nuoIUniRule annotation
ORF Names:ALYR11510_0109Imported, ALYR1151_0109Imported, ALYR1153_0109Imported, ALYR137E_0109Imported, ALYR137G_0109Imported, ALYR37C_0109Imported, ALYR37H_0109Imported, ALYR55B_0109Imported, ALYR55C_0109Imported, ALYR744_0109Imported, ALYR746_0109Imported, ALYR749_0109Imported, ALYR85D_0109Imported, ALYR85E_0109Imported, ALYR88M_0109Imported, ALYR88O_0109Imported, ALYR88P_0109Imported, ALYR88Q_0109Imported, ALYR88R_0109Imported, ALYR88S_0109Imported, ALYR88T_0109Imported, ALYR88U_0109Imported, ALYR88V_0109Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniPlastidImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis lyrata subsp. petraea (Northern rock-cress) (Cardaminopsis petraea)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri59691 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membraneUniRule annotation, ChloroplastSAAS annotationImported, Membrane, Plastid, ThylakoidSAAS annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

QuinoneUniRule annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

NDH is composed of at least 16 different subunits, 5 of which are encoded in the nucleus.SAAS annotation
NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini55 – 844Fe-4S ferredoxin-typeInterPro annotationAdd BLAST30
Domaini95 – 1244Fe-4S ferredoxin-typeInterPro annotationAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I 23 kDa subunit family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01351 NDH1_NuoI, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR004497 NADH_plast_OxRdtase_su_I
IPR010226 NADH_quinone_OxRdtase_chainI

The PANTHER Classification System

More...
PANTHERi
PTHR47275 PTHR47275, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13187 Fer4_9, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00403 ndhI, 1 hit
TIGR01971 NuoI, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A175DCT9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPMITGFMN YGQQTLRAAR YIGQGFMITL SHTNRLPVTI QYPYEKLITS
60 70 80 90 100
ERFRGRIHFE FDKCIACEVC VRVCPIDLPV VDWKLETNIR KKRLLNYSID
110 120 130 140 150
FGICIFCGNC VEYCPTNCLS MTEEYEFSTY DRHELNYNQI ALGRLPMSVI
160 170
DDYTIRTIWN SPQTKNGVNP LI
Length:172
Mass (Da):20,086
Last modified:September 7, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i931D28EC63E3AB3F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KU764768 Genomic DNA Translation: ANH21010.1
LT161943 Genomic DNA Translation: CZF91371.1
LT161944 Genomic DNA Translation: CZF91456.1
LT161945 Genomic DNA Translation: CZF91541.1
LT161946 Genomic DNA Translation: CZF91626.1
LT161947 Genomic DNA Translation: CZF91711.1
LT161948 Genomic DNA Translation: CZF91796.1
LT161949 Genomic DNA Translation: CZF91881.1
LT161950 Genomic DNA Translation: CZF91966.1
LT161951 Genomic DNA Translation: CZF92051.1
LT161952 Genomic DNA Translation: CZF92136.1
LT161953 Genomic DNA Translation: CZF92221.1
LT161954 Genomic DNA Translation: CZF92306.1
LT161955 Genomic DNA Translation: CZF92391.1
LT161956 Genomic DNA Translation: CZF92476.1
LT161957 Genomic DNA Translation: CZF92561.1
LT161958 Genomic DNA Translation: CZF92646.1
LT161959 Genomic DNA Translation: CZF92731.1
LT161960 Genomic DNA Translation: CZF92816.1
LT161961 Genomic DNA Translation: CZF92901.1
LT161962 Genomic DNA Translation: CZF92986.1
LT161963 Genomic DNA Translation: CZF93071.1
LT934243 Genomic DNA Translation: SOF61654.1
LT934377 Genomic DNA Translation: SOG99419.1
LT934372 Genomic DNA Translation: SOG99506.1
LT934375 Genomic DNA Translation: SOG99511.1
LT934370 Genomic DNA Translation: SOG99516.1
LT934371 Genomic DNA Translation: SOG99651.1
LT934369 Genomic DNA Translation: SOG99661.1
LT934380 Genomic DNA Translation: SOG99688.1
LT934367 Genomic DNA Translation: SOG99689.1
LT934381 Genomic DNA Translation: SOG99696.1
LT934368 Genomic DNA Translation: SOG99701.1
LT934366 Genomic DNA Translation: SOG99740.1
LT934383 Genomic DNA Translation: SOG99791.1
LT934362 Genomic DNA Translation: SOG99865.1
LT934379 Genomic DNA Translation: SOG99882.1
LT934365 Genomic DNA Translation: SOG99886.1
LT934360 Genomic DNA Translation: SOG99925.1
LT934364 Genomic DNA Translation: SOG99940.1
LT934378 Genomic DNA Translation: SOG99969.1
LT934384 Genomic DNA Translation: SOH00120.1
LT934385 Genomic DNA Translation: SOH00148.1
LT934373 Genomic DNA Translation: SOH00224.1
LT934388 Genomic DNA Translation: SOH00394.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KU764768 Genomic DNA Translation: ANH21010.1
LT161943 Genomic DNA Translation: CZF91371.1
LT161944 Genomic DNA Translation: CZF91456.1
LT161945 Genomic DNA Translation: CZF91541.1
LT161946 Genomic DNA Translation: CZF91626.1
LT161947 Genomic DNA Translation: CZF91711.1
LT161948 Genomic DNA Translation: CZF91796.1
LT161949 Genomic DNA Translation: CZF91881.1
LT161950 Genomic DNA Translation: CZF91966.1
LT161951 Genomic DNA Translation: CZF92051.1
LT161952 Genomic DNA Translation: CZF92136.1
LT161953 Genomic DNA Translation: CZF92221.1
LT161954 Genomic DNA Translation: CZF92306.1
LT161955 Genomic DNA Translation: CZF92391.1
LT161956 Genomic DNA Translation: CZF92476.1
LT161957 Genomic DNA Translation: CZF92561.1
LT161958 Genomic DNA Translation: CZF92646.1
LT161959 Genomic DNA Translation: CZF92731.1
LT161960 Genomic DNA Translation: CZF92816.1
LT161961 Genomic DNA Translation: CZF92901.1
LT161962 Genomic DNA Translation: CZF92986.1
LT161963 Genomic DNA Translation: CZF93071.1
LT934243 Genomic DNA Translation: SOF61654.1
LT934377 Genomic DNA Translation: SOG99419.1
LT934372 Genomic DNA Translation: SOG99506.1
LT934375 Genomic DNA Translation: SOG99511.1
LT934370 Genomic DNA Translation: SOG99516.1
LT934371 Genomic DNA Translation: SOG99651.1
LT934369 Genomic DNA Translation: SOG99661.1
LT934380 Genomic DNA Translation: SOG99688.1
LT934367 Genomic DNA Translation: SOG99689.1
LT934381 Genomic DNA Translation: SOG99696.1
LT934368 Genomic DNA Translation: SOG99701.1
LT934366 Genomic DNA Translation: SOG99740.1
LT934383 Genomic DNA Translation: SOG99791.1
LT934362 Genomic DNA Translation: SOG99865.1
LT934379 Genomic DNA Translation: SOG99882.1
LT934365 Genomic DNA Translation: SOG99886.1
LT934360 Genomic DNA Translation: SOG99925.1
LT934364 Genomic DNA Translation: SOG99940.1
LT934378 Genomic DNA Translation: SOG99969.1
LT934384 Genomic DNA Translation: SOH00120.1
LT934385 Genomic DNA Translation: SOH00148.1
LT934373 Genomic DNA Translation: SOH00224.1
LT934388 Genomic DNA Translation: SOH00394.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

HAMAPiMF_01351 NDH1_NuoI, 1 hit
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR004497 NADH_plast_OxRdtase_su_I
IPR010226 NADH_quinone_OxRdtase_chainI
PANTHERiPTHR47275 PTHR47275, 1 hit
PfamiView protein in Pfam
PF13187 Fer4_9, 1 hit
TIGRFAMsiTIGR00403 ndhI, 1 hit
TIGR01971 NuoI, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A175DCT9_ARALP
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A175DCT9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: September 7, 2016
Last sequence update: September 7, 2016
Last modified: May 8, 2019
This is version 22 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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