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Protein

N5-carboxyaminoimidazole ribonucleotide mutase

Gene

purE_2

Organism
Blautia obeum
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).UniRule annotation

Catalytic activityi

5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route).UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. N5-carboxyaminoimidazole ribonucleotide mutase (purE_2), N5-carboxyaminoimidazole ribonucleotide mutase (purE)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route), the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei10SubstrateUniRule annotation1
Binding sitei13SubstrateUniRule annotation1
Binding sitei40SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationImported
Biological processPurine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00074;UER00943

Names & Taxonomyi

Protein namesi
Recommended name:
N5-carboxyaminoimidazole ribonucleotide mutaseUniRule annotation (EC:5.4.99.18UniRule annotation)
Short name:
N5-CAIR mutaseUniRule annotation
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide mutaseUniRule annotation
Gene namesi
Name:purE_2Imported
Synonyms:purEUniRule annotation, purE_1Imported
ORF Names:ERS852395_02423Imported, ERS852476_00013Imported, ERS852569_01810Imported
OrganismiBlautia obeumImported
Taxonomic identifieri40520 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceaeBlautia
Proteomesi
  • UP000095645 Componenti: Unassembled WGS sequence
  • UP000095762 Componenti: Unassembled WGS sequence
  • UP000095447 Componenti: Unassembled WGS sequence

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 151AIRCInterPro annotationAdd BLAST150

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili137 – 157Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the AIR carboxylase family. Class I subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3Di3.40.50.7700, 1 hit
HAMAPiMF_01929 PurE_classI, 1 hit
InterProiView protein in InterPro
IPR033747 PurE_ClassI
IPR000031 PurE_dom
IPR024694 PurE_prokaryotes
IPR035893 PurE_sf
PfamiView protein in Pfam
PF00731 AIRC, 1 hit
PIRSFiPIRSF001338 AIR_carboxylase, 1 hit
SMARTiView protein in SMART
SM01001 AIRC, 1 hit
SUPFAMiSSF52255 SSF52255, 1 hit
TIGRFAMsiTIGR01162 purE, 1 hit

Sequencei

Sequence statusi: Complete.

A0A174TEA9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKVGIVMGS DSDMPIMSKA ADILEKLGID YEIKIISAHR EPDVFFEYAK
60 70 80 90 100
TAEEKGFKVI IAGAGMAAHL PGMCAAIFPM PVIGIPMHTT SLGGRDSLYS
110 120 130 140 150
IVQMPSGIPV ATVAINGGAN AGLLAAKILA TSDEELLAKL KAYSQELKEQ
160
VEAKDARLQE VGYKNY
Length:166
Mass (Da):17,658
Last modified:September 7, 2016 - v1
Checksum:i34B736B00306529A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CYZP01000001 Genomic DNA Translation: CUN41021.1
CYZA01000013 Genomic DNA Translation: CUO23249.1
CZBP01000012 Genomic DNA Translation: CUQ06811.1
RefSeqiWP_008705484.1, NZ_CZBP01000012.1

Genome annotation databases

GeneIDi31622224

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CYZP01000001 Genomic DNA Translation: CUN41021.1
CYZA01000013 Genomic DNA Translation: CUO23249.1
CZBP01000012 Genomic DNA Translation: CUQ06811.1
RefSeqiWP_008705484.1, NZ_CZBP01000012.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi31622224

Enzyme and pathway databases

UniPathwayi
UPA00074;UER00943

Family and domain databases

Gene3Di3.40.50.7700, 1 hit
HAMAPiMF_01929 PurE_classI, 1 hit
InterProiView protein in InterPro
IPR033747 PurE_ClassI
IPR000031 PurE_dom
IPR024694 PurE_prokaryotes
IPR035893 PurE_sf
PfamiView protein in Pfam
PF00731 AIRC, 1 hit
PIRSFiPIRSF001338 AIR_carboxylase, 1 hit
SMARTiView protein in SMART
SM01001 AIRC, 1 hit
SUPFAMiSSF52255 SSF52255, 1 hit
TIGRFAMsiTIGR01162 purE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A174TEA9_9FIRM
AccessioniPrimary (citable) accession number: A0A174TEA9
Entry historyiIntegrated into UniProtKB/TrEMBL: September 7, 2016
Last sequence update: September 7, 2016
Last modified: March 28, 2018
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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