Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Deinococcus puniceus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei588ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotation, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
ORF Names:SU48_08970Imported
OrganismiDeinococcus puniceusImported
Taxonomic identifieri1182568 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000077363 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini46 – 188tRNA-synt_1gInterPro annotationAdd BLAST143
Domaini227 – 409tRNA-synt_1_2InterPro annotationAdd BLAST183
Domaini425 – 614tRNA-synt_1InterPro annotationAdd BLAST190
Domaini662 – 779Anticodon_1InterPro annotationAdd BLAST118

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi49 – 59"HIGH" regionUniRule annotationAdd BLAST11
Motifi585 – 589"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

KOiK01869

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit

Sequencei

Sequence statusi: Complete.

A0A172TAD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDIKEPRAE RYNPHAIEGK WQEQWAADGL YTFREDASKT KYYALTMFPY
60 70 80 90 100
PSGNLHIGHW YANVAPDARA RWMRMRGYNV LFPMGFDAFG LPAENAAIKN
110 120 130 140 150
NVNPAKWTRE NIAYMIGQFG RMGTMIDWSR SFATCDPEYY RWNQWFFTEF
160 170 180 190 200
FRRGLAYKKD GLVNWCPKDQ TVLANEQVVN GHCERCGTAV ERRKLSQWYL
210 220 230 240 250
KITDYADELL DFGDTDMPER VRLMQTNWIG KSVGAEITFD TPAGPETVFT
260 270 280 290 300
TRPDTLMGAT FLVLAPEHSK VAALTSPEQA DTVRAYLEAA GRKTDVERQQ
310 320 330 340 350
DSGEKTGVFT GSYATHPISG HQVPIWVADY VLVTYGTGSI MAVPAHDERD
360 370 380 390 400
FAFARKFGLE IREVIRPEGG AGMGENPEAS YNGEGLIVNS GEFDGLRGGK
410 420 430 440 450
ASIAQIIAKL DEHGVAKAKT TFRLRDWLVS RQRYWGTPIP IVYCEEHGAQ
460 470 480 490 500
PVPADQLPVR LPDNVEFTPA GQSPLKLNRE WVQTTCPVCG GPAERDTDTM
510 520 530 540 550
DTFVDSSWYM YRFLSPRDEV HPFDPAEAGK LPVDLYTGGI EHAILHLLYS
560 570 580 590 600
RFWTKAMRDM GLTEQNEPFK WLRNQGMILG PDGDKMSKSR GNVVDPDDLV
610 620 630 640 650
REYGADTVRA YLLSIAPWED GGPWDPTGIQ GPARWLSRVW RLYFDEEGSG
660 670 680 690 700
PAKSVTEAEL RYATHSALKR VTDDFERLNF NTIFATLNIL TDALADAKRS
710 720 730 740 750
PVRATPAYAE ALDILNLMLA PVVPHVAEEI WHERGNSGSI HTQSWPAVDE
760 770 780 790 800
AAATRDTVTL GVQVSGKVRG EVTISKTATQ AEAMAAAQAL PDVQKYTEGK
810
TVVKEVYVPG RIINIVVK
Length:818
Mass (Da):91,658
Last modified:September 7, 2016 - v1
Checksum:i44CCF63F2AA5C8C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP011387 Genomic DNA Translation: ANE43887.1
RefSeqiWP_064014955.1, NZ_CP011387.1

Genome annotation databases

EnsemblBacteriaiANE43887; ANE43887; SU48_08970
KEGGidpu:SU48_08970
PATRICifig|1182568.3.peg.1867

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP011387 Genomic DNA Translation: ANE43887.1
RefSeqiWP_064014955.1, NZ_CP011387.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiANE43887; ANE43887; SU48_08970
KEGGidpu:SU48_08970
PATRICifig|1182568.3.peg.1867

Phylogenomic databases

KOiK01869

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A172TAD1_9DEIO
AccessioniPrimary (citable) accession number: A0A172TAD1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 7, 2016
Last sequence update: September 7, 2016
Last modified: March 28, 2018
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again