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Protein

Methyl-coenzyme M reductase subunit alpha

Gene

MBCUT_02940

Organism
Methanobrevibacter cuticularis
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Methyl-CoM + CoB = CoM-S-S-CoB + methane.UniRule annotation

Cofactori

coenzyme F430UniRule annotationNote: Binds 1 coenzyme F430 noncovalently per subunit. Coenzyme F430 is a yellow nickel porphinoid.UniRule annotation

Pathwayi: methyl-coenzyme M reduction

This protein is involved in step 1 of the subpathway that synthesizes methane from methyl-coenzyme M.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Methyl-coenzyme M reductase subunit beta (MBCUT_02900), Methyl-coenzyme M reductase subunit alpha (MBCUT_02940), Methyl-coenzyme M reductase subunit gamma (MBCUT_02930)
This subpathway is part of the pathway methyl-coenzyme M reduction, which is itself part of One-carbon metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes methane from methyl-coenzyme M, the pathway methyl-coenzyme M reduction and in One-carbon metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi147NickelUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation
Biological processMethanogenesisUniRule annotation
LigandMetal-bindingUniRule annotation, NickelUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00646; UER00699

Names & Taxonomyi

Protein namesi
Recommended name:
Methyl-coenzyme M reductase subunit alphaUniRule annotation (EC:2.8.4.1UniRule annotation)
Gene namesi
ORF Names:MBCUT_02940Imported
OrganismiMethanobrevibacter cuticularisImported
Taxonomic identifieri47311 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanobrevibacter
Proteomesi
  • UP000077275 Componenti: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei257Pros-methylhistidineUniRule annotation1
Modified residuei2715-methylarginineUniRule annotation1

Interactioni

Subunit structurei

Hexamer of two alpha, two beta, and two gamma chains.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 268MCR_alpha_NInterPro annotationAdd BLAST265
Domaini316 – 442MCR_alphaInterPro annotationAdd BLAST127

Family and domain databases

Gene3Di1.20.840.10, 1 hit
3.30.70.470, 1 hit
3.90.390.10, 1 hit
InterProiView protein in InterPro
IPR016212 Me_CoM_Rdtase_asu
IPR008924 Me_CoM_Rdtase_asu/bsu_C
IPR009047 Me_CoM_Rdtase_asu_C
IPR003183 Me_CoM_Rdtase_asu_N
IPR015811 Me_CoM_Rdtase_asu_N_sub1
IPR015823 Me_CoM_Rdtase_asu_N_sub2
IPR009024 Me_CoM_Rdtase_Fd-like_fold
PfamiView protein in Pfam
PF02249 MCR_alpha, 1 hit
PF02745 MCR_alpha_N, 1 hit
PIRSFiPIRSF000262 MCR_alpha, 1 hit
SUPFAMiSSF48081 SSF48081, 1 hit
SSF55088 SSF55088, 1 hit
TIGRFAMsiTIGR03256 met_CoM_red_alp, 1 hit

Sequencei

Sequence statusi: Complete.

A0A166CWD2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANKKFIEAL NKKFKESPEE KTTTFYNLGG WKQSERKSEF AKEGKEIATK
60 70 80 90 100
RGIPQYNPDV GSPLGQRALM PYQVSTTETF VEGDDFHFVN NAAIQQMWDD
110 120 130 140 150
IRRTVIVGLN TAHTVLEKRL GIEVTPETIT EYLETVNHAM PGAAVVQEHM
160 170 180 190 200
VETNPALVAD SYVKIFTGDD EVADEIDSAF VLDINKEFSK EQAEALKAEV
210 220 230 240 250
GDKIWQVVRI PSIVGRVCDG GTTSRWSAMQ IGMSMISAYN QCAGEGATGD
260 270 280 290 300
FAYASKHAEV IHMGTYLPVR RARAENEPGG IPFGYMADIC QSSRVNEDDP
310 320 330 340 350
VRTTLDVVAM SAALYDQIWL GSYMSGGVGF TQYASAAYTD NVLDDFTYYG
360 370 380 390 400
KEYVEDKYGG LCEAPNNMDT VLDVGSEVTF YGLEQYEEYP ALLETQFGGS
410 420 430 440 450
QRASVVSAAA GCSTAFATGN AQTGLSAWYL SMYLHKEQHS RLGFYGYDLQ
460 470 480 490 500
DQCGASNVFS IRADEGLPVE MRGPNYPNYA MNVGHQGEYA GISQAPHAAR
510 520 530 540 550
KDAFAFNPLI KIAFADKNLS FDFSQPRAEI AKGALREFMP DGERSLIIPA

K
Length:551
Mass (Da):60,678
Last modified:July 6, 2016 - v1
Checksum:iA34E0EFC156AFE24
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LWMW01000054 Genomic DNA Translation: KZX17247.1
RefSeqiWP_067257927.1, NZ_LWMW01000054.1

Genome annotation databases

EnsemblBacteriaiKZX17247; KZX17247; MBCUT_02940
PATRICifig|47311.3.peg.324

Similar proteinsi

Entry informationi

Entry nameiA0A166CWD2_9EURY
AccessioniPrimary (citable) accession number: A0A166CWD2
Entry historyiIntegrated into UniProtKB/TrEMBL: July 6, 2016
Last sequence update: July 6, 2016
Last modified: October 25, 2017
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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