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Protein

Glutamate-1-semialdehyde 2,1-aminomutase

Gene

hemL

Organism
Pelodictyon luteolum
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: protoporphyrin-IX biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu).SAAS annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Glutamyl-tRNA reductase (hemA)
  2. Glutamate-1-semialdehyde 2,1-aminomutase (hemL)
This subpathway is part of the pathway protoporphyrin-IX biosynthesis, which is itself part of Porphyrin-containing compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-aminolevulinate from L-glutamyl-tRNA(Glu), the pathway protoporphyrin-IX biosynthesis and in Porphyrin-containing compound metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferaseImported, IsomeraseUniRule annotationSAAS annotation, Transferase
Biological processPorphyrin biosynthesisUniRule annotationSAAS annotation
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00251; UER00317

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutaseUniRule annotation (EC:5.4.3.8UniRule annotation)
Short name:
GSAUniRule annotation
Alternative name(s):
Glutamate-1-semialdehyde aminotransferaseUniRule annotation
Short name:
GSA-ATUniRule annotation
Gene namesi
Name:hemLUniRule annotation
ORF Names:A3K90_09775Imported
OrganismiPelodictyon luteolumImported
Taxonomic identifieri1100 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobium/Pelodictyon groupPelodictyon
Proteomesi
  • UP000076481 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei269N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00610 OAT_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00375 HemL_aminotrans_3, 1 hit
InterProiView protein in InterPro
IPR004639 4pyrrol_synth_GluAld_NH2Trfase
IPR005814 Aminotrans_3
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00202 Aminotran_3, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR00713 hemL, 1 hit
PROSITEiView protein in PROSITE
PS00600 AA_TRANSFER_CLASS_3, 1 hit

Sequencei

Sequence statusi: Complete.

A0A165M719-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPTLTRSAEL FEKAKKFIPG GVNSPVRAFK SVGGNPIFMA KGQGAYMTDV
60 70 80 90 100
DGNTYLDYVG SWGPFILGSM HPRITAALEF TLTKIGTSFG TPIEMEIEIA
110 120 130 140 150
ELLTKIVPSI EMVRMVNSGT EATMSAVRLA RGCTGRDKII KFEGCYHGHG
160 170 180 190 200
DSFLIKAGSG ALTLGAPDSP GVTKGTAQDT LNAKYNDIKS VELLVAENKG
210 220 230 240 250
NIAAIIIEPV AGNTGVIPAK KEFLQALRDL CDREGIVLIF DEVMCGFRVA
260 270 280 290 300
LGGAQELYGI TPDLTTMGKI IGGGLPVGAF GGKRSLMENI APLGGVYQAG
310 320 330 340 350
TLSGNPLALT AGIETLKILM EENPYPELER KAAFLEAGFR DNMQKLGLNF
360 370 380 390 400
VQNRVGSMAC LFFTETPVES YDSAITADTV KFGKYFSSML EQGIYLAPSQ
410 420 430
FEAMFTSTMH TDADLEKTVK ANYVALQAAT K
Length:431
Mass (Da):46,113
Last modified:July 6, 2016 - v1
Checksum:iB67E9F3FD3C67022
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LVWG01000017 Genomic DNA Translation: KZK74890.1

Similar proteinsi

Entry informationi

Entry nameiA0A165M719_PELLU
AccessioniPrimary (citable) accession number: A0A165M719
Entry historyiIntegrated into UniProtKB/TrEMBL: July 6, 2016
Last sequence update: July 6, 2016
Last modified: March 28, 2018
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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