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Protein

2,3-bisphosphoglycerate-independent phosphoglycerate mutase

Gene

gpmI

Organism
Bacillus cereus (strain 03BB102)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.SAAS annotation
Essential for rapid growth and for sporulation. Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Cofactori

Mn2+UniRule annotationNote: Binds 2 manganese ions per subunit.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotationSAAS annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase (gpmI)
  4. Enolase (eno)
  5. Pyruvate kinase (pykA1), Pyruvate kinase (pyk)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi11Manganese 2UniRule annotation1
Active sitei61Phosphoserine intermediateUniRule annotation1
Metal bindingi61Manganese 2UniRule annotation1
Binding sitei122SubstrateUniRule annotation1
Binding sitei184SubstrateUniRule annotation1
Binding sitei190SubstrateUniRule annotation1
Binding sitei335SubstrateUniRule annotation1
Metal bindingi402Manganese 1UniRule annotation1
Metal bindingi406Manganese 1UniRule annotation1
Metal bindingi443Manganese 2UniRule annotation1
Metal bindingi444Manganese 2UniRule annotation1
Metal bindingi461Manganese 1UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
Biological processGlycolysisUniRule annotationSAAS annotation, SporulationUniRule annotation
LigandManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.12UniRule annotation)
Short name:
BPG-independent PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
iPGMUniRule annotation
Gene namesi
Name:gpmIUniRule annotationImported
Ordered Locus Names:BCA_5247Imported
OrganismiBacillus cereus (strain 03BB102)Imported
Taxonomic identifieri572264 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000002210 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35PhosphotyrosineUniRule annotation1

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0A158RKG3
SMRiA0A158RKG3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 497MetalloenzymeInterPro annotationAdd BLAST495
Domaini81 – 298iPGM_NInterPro annotationAdd BLAST218

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni152 – 153Substrate bindingUniRule annotation2
Regioni260 – 263Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the BPG-independent phosphoglycerate mutase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK15633
OMAiFMDGRDT

Family and domain databases

CDDicd16010 iPGM, 1 hit
Gene3Di3.40.1450.10, 1 hit
3.40.720.10, 2 hits
HAMAPiMF_01038 GpmI, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR011258 BPG-indep_PGM_N
IPR006124 Metalloenzyme
IPR036646 PGAM_B_sf
IPR005995 Pgm_bpd_ind
PANTHERiPTHR31637 PTHR31637, 1 hit
PfamiView protein in Pfam
PF06415 iPGM_N, 1 hit
PF01676 Metalloenzyme, 1 hit
PIRSFiPIRSF001492 IPGAM, 1 hit
SUPFAMiSSF53649 SSF53649, 2 hits
SSF64158 SSF64158, 1 hit
TIGRFAMsiTIGR01307 pgm_bpd_ind, 1 hit

Sequencei

Sequence statusi: Complete.

A0A158RKG3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRKPTALIIL DGFGLREETY GNAVAQAKKP NFDGYWNKFP HTTLTACGEA
60 70 80 90 100
VGLPEGQMGN SEVGHLNIGA GRIVYQSLTR VNVAIREGEF DKNETFQSAI
110 120 130 140 150
KSVKEKGTAL HLFGLLSDGG VHSHMNHMFA LLRLAAKEGV EKVYIHAFLD
160 170 180 190 200
GRDVGPKTAQ SYIDATNEVM KETGVGQFAT ISGRYYSMDR DKRWDRVEKC
210 220 230 240 250
YRAMVNGEGP TYKSAEECVE DSYANGIYDE FVLPSVIVNE DNTPVATIND
260 270 280 290 300
DDAVIFYNFR PDRAIQIARV FTNEDFREFD RGEKVPHIPE FVCMTHFSET
310 320 330 340 350
VDGYVAFKPM NLDNTLGEVV AQAGLKQLRI AETEKYPHVT FFFSGGREAE
360 370 380 390 400
FPGEERILIN SPKVATYDLK PEMSIYEVTD ALVNEIENDK HDVIILNFAN
410 420 430 440 450
CDMVGHSGMM EPTIKAVEAT DECLGKVVEA ILAKDGVALI TADHGNADEE
460 470 480 490 500
LTSEGEPMTA HTTNPVPFIV TKNDVELREG GILGDIAPTM LTLLGVEQPK

EMTGKTIIK
Length:509
Mass (Da):56,313
Last modified:June 8, 2016 - v1
Checksum:i0AD5F81870B99B7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001407 Genomic DNA Translation: ACO27570.1
RefSeqiWP_001231156.1, NZ_CP009318.1

Genome annotation databases

EnsemblBacteriaiACO27570; ACO27570; BCA_5247
KEGGibcx:BCA_5247
PATRICifig|572264.18.peg.5170

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001407 Genomic DNA Translation: ACO27570.1
RefSeqiWP_001231156.1, NZ_CP009318.1

3D structure databases

ProteinModelPortaliA0A158RKG3
SMRiA0A158RKG3
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACO27570; ACO27570; BCA_5247
KEGGibcx:BCA_5247
PATRICifig|572264.18.peg.5170

Phylogenomic databases

KOiK15633
OMAiFMDGRDT

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00186

Family and domain databases

CDDicd16010 iPGM, 1 hit
Gene3Di3.40.1450.10, 1 hit
3.40.720.10, 2 hits
HAMAPiMF_01038 GpmI, 1 hit
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR011258 BPG-indep_PGM_N
IPR006124 Metalloenzyme
IPR036646 PGAM_B_sf
IPR005995 Pgm_bpd_ind
PANTHERiPTHR31637 PTHR31637, 1 hit
PfamiView protein in Pfam
PF06415 iPGM_N, 1 hit
PF01676 Metalloenzyme, 1 hit
PIRSFiPIRSF001492 IPGAM, 1 hit
SUPFAMiSSF53649 SSF53649, 2 hits
SSF64158 SSF64158, 1 hit
TIGRFAMsiTIGR01307 pgm_bpd_ind, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A158RKG3_BACC3
AccessioniPrimary (citable) accession number: A0A158RKG3
Entry historyiIntegrated into UniProtKB/TrEMBL: June 8, 2016
Last sequence update: June 8, 2016
Last modified: February 28, 2018
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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