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Entry version 16 (11 Dec 2019)
Sequence version 1 (08 Jun 2016)
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Protein
Submitted name:

Uncharacterized protein

Gene

DME_LOCUS6999

Organism
Dracunculus medinensis (Guinea worm)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:DME_LOCUS6999Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDracunculus medinensis (Guinea worm)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri318479 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaSpirurinaDracunculoideaDracunculidaeDracunculus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000274756 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000038040 Componenti: Genome Assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2156 – 2180HelicalSequence analysisAdd BLAST25
Transmembranei2195 – 2211HelicalSequence analysisAdd BLAST17
Transmembranei2218 – 2239HelicalSequence analysisAdd BLAST22
Transmembranei2259 – 2286HelicalSequence analysisAdd BLAST28
Transmembranei2307 – 2329HelicalSequence analysisAdd BLAST23
Transmembranei2396 – 2419HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini142 – 196MIRInterPro annotationAdd BLAST55
Domaini271 – 329MIRInterPro annotationAdd BLAST59
Domaini336 – 395MIRInterPro annotationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili119 – 139Sequence analysisAdd BLAST21
Coiled coili2533 – 2553Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014821 Ins145_P3_rcpt
IPR000493 InsP3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR035910 RyR/IP3R_RIH_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF01365 RYDR_ITPR, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00779 INSP3RECEPTR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00472 MIR, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF100909 SSF100909, 2 hits
SSF82109 SSF82109, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50919 MIR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A158Q3L2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNLGSNKTRQ KLFYDKSNLS SEVFHNSTLH IGDVISLYTE DRSRQSDDRN
60 70 80 90 100
DDRTFIKTGL VDDRCIVEIG DGNPEAPPKK FRDCLFRICP INRYAAQKQF
110 120 130 140 150
WTEQKRFREG ESVFEEDMLA KLKNAADKEK EQNEMEYQKM LGSIVQYGGT
160 170 180 190 200
IQLLHVKSDK YLTVMKNTPA KLERNAMKVC LDKTGNEGSW FYVETVYKHS
210 220 230 240 250
FLGDNVNSGD RISLVPYSYG SLSGNTGIIK PQIHLSHMRL PDHPQGYEVN
260 270 280 290 300
CVNEHTEWQV FVFLQFDENR GDIIKSGDVI RLFHADQQTF LTLDTIPKKG
310 320 330 340 350
KDVVFLRLTN RPSAADATSS RALWEVQVVQ NEACRGAAAA WHERFRFKHL
360 370 380 390 400
ASDMFLTVKS ARDMRDVLDM PPASSIPENI FDYSKNEKGW VKVIGEDQRV
410 420 430 440 450
DKETFALLSV HPNEVRDLDF ANDACKALTN FIDLIKSGKI IAKESLNIIV
460 470 480 490 500
QLLTECIYFV TNQANHLVDP LKIVDFIPSR DRQKLLREQG VLKQTFELLR
510 520 530 540 550
VPFEPRRGIM GPLLLSPQEL NEQRNDVFKR MFQLCYSLLR YSQVRYRKNQ
560 570 580 590 600
EHLAEQFGLI QQQIGFDLLA EDTMTAVLHN NPKLLEKYVK DPHVQRFVEL
610 620 630 640 650
VRNNKTGKFL DYLADLCVCR GEANKKVQEL ICNCVLSEAN RDIFMLQIKW
660 670 680 690 700
GDRYMKSLIA MAKGVSIGDQ EDSEMLDYYK HQLDLFAQMC QEQQYLAIDP
710 720 730 740 750
PPERHLLNLS AELPPDLVLK CMSDSRLPDN LRASFARLML HLHVVRGSPL
760 770 780 790 800
NAIRYARLWK EIPERVSILN CSSRPVEGYA TSGRARSGYA NLLKAVSDYL
810 820 830 840 850
LSLKNITKSG ENVLNDHSSR LEQNRLTFEM VTLARALAQF GFYSFAQLLQ
860 870 880 890 900
LAESLLAITD NNSSTTPASH FFHQVTYSVM GVGMLEKSGT LNSTLANDAV
910 920 930 940 950
DVEENVRSKA SKDIIMEIKL IVVEILQFIM DVRRDYRITV ALSWFKQKNP
960 970 980 990 1000
CDEYGELTEP QALTTKHAME IYKEIFERTE EQLECGGQHG RQLLKTLLQL
1010 1020 1030 1040 1050
ATSECAKLAS SALKVLFRQF TQYHEFVDDL KQVQLLVSNE DVENYCQIDR
1060 1070 1080 1090 1100
DLFILKILTE KSELWVNAGK ASESPIIDDT LRIEDISADG LNAPRAFCND
1110 1120 1130 1140 1150
ESFHLLVDKL DEYYSPTRDD CIKLLNKLLL SDDRENAASA LFELSDKAPL
1160 1170 1180 1190 1200
IGYPLIKQIL FRLKQLCYKN GSNDIMNQQL LKNMRVHEYV LGFLSIPYDK
1210 1220 1230 1240 1250
RVDQEMPKLF TLCHEFLQSF CRNNKLNQYC LQRYISVDSD HKEGCLRIDT
1260 1270 1280 1290 1300
VEDVATLVAI YKNNRKLSEN ISGDIIARVI DLIEQKARNA VFIEFLQCVV
1310 1320 1330 1340 1350
CTDEGEIESS QEKVVQEICS ASDEVRVFYS DSASFEQLIQ MMKNTPVEEL
1360 1370 1380 1390 1400
TADNPLRYHI ELVRLLAMCT RGKNGTMELK CASQLPIDHI MRVLSSPHCL
1410 1420 1430 1440 1450
VQVKDVYMQF MLHCYIDTGA EMKDVYNADY FELILQNILS DVEEVPLERY
1460 1470 1480 1490 1500
ICLTVIEILS SLFQKPLSYQ TTMDVVSHIT IYFLYKSSVK TLRSASKNWH
1510 1520 1530 1540 1550
RFAESLKRLN KCGSYFSILQ NYNHEFEESS RFLEDAETSV LVDLLYSPER
1560 1570 1580 1590 1600
LFPKGSEMRE RCEKGETIAK LIEHCKQLLE EKQENLCVRV LHTLCHMATN
1610 1620 1630 1640 1650
TKFICRDQVN CLFHIFTRTN CKIGICLRQH LLQRYFGDES ERRRSKFGSI
1660 1670 1680 1690 1700
IEKQERKPSS SNLCRNYFPT ILFTDLFSDL VIDLIIEEPS YDVFYMTMEL
1710 1720 1730 1740 1750
AKSLLQEGNE QVQKSFYKRL TQQRDVSETF VQAIKTKLQV AQNRVKNDMM
1760 1770 1780 1790 1800
ACNDSRQPSC LQTPLANDLT LQNEHRGSLD TSINLMSLQA ENIDAIYFYR
1810 1820 1830 1840 1850
SKKSLPPEVL IIEPILRFLQ LLCENHNLSL QNFLRCQGSR KNYNLVDETL
1860 1870 1880 1890 1900
TFLDVICGST KGSLGVFGDI GEHNFSLIIQ TLTTLTEFCQ GPCHENQNAI
1910 1920 1930 1940 1950
VYHETGLNMI ISLVLNEIKP LCISHMDLAL EIKSVASKLL LATMESRHDA
1960 1970 1980 1990 2000
SNAEAVLLNM SHMNSGPTQL IHALTVAYQM ANSDTYVLSR MRRQLLENNI
2010 2020 2030 2040 2050
SGQVLPEISV HGPVKNIFDQ KFSYSNLVDP QEVGHNIFIL ATQLSRHDKS
2060 2070 2080 2090 2100
LRDLLTADYF DCEMTRVAIT YYKQHTAQIE IVREDRRMER VIFPIHTICK
2110 2120 2130 2140 2150
YLTPETKQNL LVETERDAQG SKVSQFFDQW PKLFQEMKWQ RKLQDRKYLS
2160 2170 2180 2190 2200
SCTKHLILWA RLSFLFAIFT NIITAIYYPF NEDTRHASFG REPEAYIGIA
2210 2220 2230 2240 2250
VVMFISTLLA IRSLDVLLTL QLIGILQLVN KFVHILSYIG NRGLIDRTWS
2260 2270 2280 2290 2300
DRINDRDIWY HLLYVVICLF GLSIHPLFYA LLLFDIVSSD ETLRNVISSV
2310 2320 2330 2340 2350
TRNWQSIIMT GLLALILVYL FSIIGYLFFQ KDFRLEVDPM NSYAGESKAN
2360 2370 2380 2390 2400
DGKIWSCQTL RMCIITTLNW GLRNGGGIGD ILRNVPPDEE SFFPRILYDM
2410 2420 2430 2440 2450
SFFIVLIIIV LNLVFGVIID TFGDLRAERN EKDDILRNTC FICGLERGRF
2460 2470 2480 2490 2500
DNKKVTFEEH RKNEHNLYHY LYFIVWLQIK DETEFTGPES YVAQCIKDRN
2510 2520 2530 2540 2550
NDWFPHMQAM SLIDGEGQEL EQPEEFNNLK EMLNTLLAVS KNHDRQLEEL
2560
RQQFVAFSKF SAVS
Length:2,564
Mass (Da):295,685
Last modified:June 8, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD0F4DF1B43BB4D7B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
UYYG01001158 Genomic DNA Translation: VDN57026.1

Genome annotation databases

WormBase ParaSite

More...
WBParaSitei
DME_0000263901-mRNA-1; DME_0000263901-mRNA-1; DME_0000263901

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
UYYG01001158 Genomic DNA Translation: VDN57026.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

WBParaSiteiDME_0000263901-mRNA-1; DME_0000263901-mRNA-1; DME_0000263901

Family and domain databases

InterProiView protein in InterPro
IPR014821 Ins145_P3_rcpt
IPR000493 InsP3_rcpt
IPR005821 Ion_trans_dom
IPR036300 MIR_dom_sf
IPR016093 MIR_motif
IPR013662 RIH_assoc-dom
IPR000699 RIH_dom
IPR035910 RyR/IP3R_RIH_dom_sf
PfamiView protein in Pfam
PF08709 Ins145_P3_rec, 1 hit
PF00520 Ion_trans, 1 hit
PF02815 MIR, 1 hit
PF08454 RIH_assoc, 1 hit
PF01365 RYDR_ITPR, 2 hits
PRINTSiPR00779 INSP3RECEPTR
SMARTiView protein in SMART
SM00472 MIR, 3 hits
SUPFAMiSSF100909 SSF100909, 2 hits
SSF82109 SSF82109, 2 hits
PROSITEiView protein in PROSITE
PS50919 MIR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A158Q3L2_DRAME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A158Q3L2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 8, 2016
Last sequence update: June 8, 2016
Last modified: December 11, 2019
This is version 16 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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