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Entry version 12 (16 Jan 2019)
Sequence version 1 (08 Jun 2016)
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Protein
Submitted name:

CDK5 regulatory subunit-associated protein 2 isoform A

Gene

CDK5RAP2

Organism
Alligator mississippiensis (American alligator)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
CDK5 regulatory subunit-associated protein 2 isoform AImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDK5RAP2Imported
ORF Names:Y1Q_0005625Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAlligator mississippiensis (American alligator)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8496 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaCrocodyliaAlligatoridaeAlligatorinaeAlligator
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000050525 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 128Cnn_1NInterPro annotationAdd BLAST72

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili58 – 78Sequence analysisAdd BLAST21
Coiled coili101 – 128Sequence analysisAdd BLAST28
Coiled coili148 – 189Sequence analysisAdd BLAST42
Coiled coili218 – 238Sequence analysisAdd BLAST21
Coiled coili273 – 307Sequence analysisAdd BLAST35
Coiled coili315 – 349Sequence analysisAdd BLAST35
Coiled coili361 – 451Sequence analysisAdd BLAST91
Coiled coili488 – 529Sequence analysisAdd BLAST42
Coiled coili581 – 625Sequence analysisAdd BLAST45
Coiled coili656 – 683Sequence analysisAdd BLAST28
Coiled coili1095 – 1115Sequence analysisAdd BLAST21
Coiled coili1151 – 1171Sequence analysisAdd BLAST21
Coiled coili1245 – 1265Sequence analysisAdd BLAST21
Coiled coili1341 – 1361Sequence analysisAdd BLAST21
Coiled coili1446 – 1484Sequence analysisAdd BLAST39
Coiled coili1544 – 1578Sequence analysisAdd BLAST35
Coiled coili1607 – 1627Sequence analysisAdd BLAST21
Coiled coili1648 – 1686Sequence analysisAdd BLAST39
Coiled coili1875 – 1902Sequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K16542

Database of Orthologous Groups

More...
OrthoDBi
1046642at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012943 Cnn_1N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07989 Cnn_1N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

A0A151MFM6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSLPGDDPT LPLDLGGSVN VADLPDVPGD AARPGSAGSA ALPDLAEDAV
60 70 80 90 100
SPTRARTMKD YENQITDLKK ENFNLKLRIY FLEERMQQKF DGPTEDIYKI
110 120 130 140 150
NIELKVEVQS LKRELQEREK LLIKASKAVE SLAQGGDTEV QRVKEAARKK
160 170 180 190 200
VEQVEEILTS RINLLEENLK AAQEEVEKAF AMMEREKVLR MAAEQKLFLV
210 220 230 240 250
SNPKDLDTVA GNEKDRLLEQ LNLSLKSKEA IIQHLEEEKS QSGPFDGSLS
260 270 280 290 300
AEKIRELTVA LRHEKDSEIE ALKMELRNER NFFEKKIQSL QEELQERESE
310 320 330 340 350
LAIEKKNGLK RDKTIQGLTL ALKTKEKENE ELGSEIEDLN VSLVNAREAT
360 370 380 390 400
HKAQIQKFKG AEDYQALLME KEALLAELRS ENLTKDTENR KLQRRIKRTD
410 420 430 440 450
QELNDLNLER EKMEKELDEA QLQKSRCDKT INDLRNQLEK LHGEMIEKEK
460 470 480 490 500
AVEHHYNILL SESNQKLQSQ ELVIKRLTDS VNQKDLLLQK LDGTIKEKEV
510 520 530 540 550
EFQDLLNKYK NLLKVKEELE LKNEGLIKEK CAAESEQSIT KIVKEVEVKK
560 570 580 590 600
ESEYEELILA LRKEQHIYST LVKALKDSDS INSLQAELNN IFLLRKQLEE
610 620 630 640 650
DILANRNLRK VLEDQIKEIK NKGEETLSYC GDQTSYMSIC LGEHSLLSLQ
660 670 680 690 700
VDHLSLEELK KKVTELLSVV KDLQSINQDL KKEQLGFSRF DSQGEETLKI
710 720 730 740 750
FNQNEFLERT EETVTPAEDF QNDKNTQSCQ PSEKTSEITP VDISEGFCKD
760 770 780 790 800
RHYRNLNKPQ VEHDRAGKHF GRIEMSEHEA AEMSLFTSLL NENGTSVLES
810 820 830 840 850
RQEQMKIVSE LLDHLNTTKE ECSIEEIENK DEKDLRQMII QLRTELKYFK
860 870 880 890 900
QVNKFLKQQE ELKSTVDGKE KLYPDTAPQI NKDIELLKVE LKDTATQTMT
910 920 930 940 950
IEGNVMRFKH EGKKEALEEK KYSRLNAEKD HQQENVFKED EQHERLSRAS
960 970 980 990 1000
RTNKSDSVYP SKKSRLPVPL KSSRSLGNIP LASCTHKPDM HLQHRIMAVD
1010 1020 1030 1040 1050
EGLKESKMQN DQLQQQTTRD KELSLSKSLI ENFQETPLEQ KRASVRAESV
1060 1070 1080 1090 1100
INLDYKEVQV DALDGGFDTH DKNENKTNNS QRERQETENH HNISNMNNQH
1110 1120 1130 1140 1150
SMKELNKEID SMENEDIDSA MTYSGSHSLL SHKLSVTSTD TFADHEVMDD
1160 1170 1180 1190 1200
IEELRQRIRV MKSELDRYKM FIFHLQPTTQ FLASDIFNII SNDAALSTEG
1210 1220 1230 1240 1250
DVLQMQDTEG QQSNTCSTVH QQVDYEIHIE NLNSRLSGTP EEQTADRLKQ
1260 1270 1280 1290 1300
LLLENEAELE KEQIANMRLL DEVYHLQTKL RESSPSNYDS LVQSQARELS
1310 1320 1330 1340 1350
FQRQQIKEIH SISVTYYQHL TSLIKAFEEL LQASDVDYYV AEGFREQLNQ
1360 1370 1380 1390 1400
SVQLFEKLEK KFLYGELIDM EVTKLCELGQ RDNEKTTTMY QSPKDESPVP
1410 1420 1430 1440 1450
SAFHSFSDFE MSEKSSLGSP ELKQDLMEGQ HGTLALLPNK FPPELLMEHL
1460 1470 1480 1490 1500
QEIRTLRQRL EDSIKTNERL RKQLERQVTD MELDQGSANI FIHGTEQHNS
1510 1520 1530 1540 1550
LTSEIHFLRK QNQVLNIMLA KGSRDKQKEN EKLRESLSKK SAAIEHLHKD
1560 1570 1580 1590 1600
YGCVKKENER LQKQISKKED ENRHLTHEIY SNRNELNRLQ TELNAKQHQL
1610 1620 1630 1640 1650
CENDKLLQSL RIELKVYEKL EEASRRRTDP GHDASEEFRK DQNNPLDLHE
1660 1670 1680 1690 1700
LLTEIQSLRV QLERSIETNK TLHEKLEEQL SKEKREEVGS VSPVNINYLF
1710 1720 1730 1740 1750
KHESQHCTGM NEVGQTFPAA DSNICELQKH GHYTSMKADT QLACKEDVDN
1760 1770 1780 1790 1800
SSQCSSISST GTSCTPRLVP GHRMWADKTG RHILGLIEDY NALRKQISEG
1810 1820 1830 1840 1850
QKLLSEMEGP LIEITSMKHV EPGVKGPAQT SLNSFSANIH TVQQNLEEAA
1860 1870 1880 1890 1900
RLLKLLWRVS LPMKVVHSTA HYSQDEGMKA EILRLRKKLS EQEKKLHSMV
1910 1920 1930 1940 1950
KRLHSTNQLK ENMEKVIIDQ LALTHDVLKK ARGNLEIQPD ENQKAASHTN

KKRIL
Length:1,955
Mass (Da):225,531
Last modified:June 8, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i00348263F1AA9893
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A151MF86A0A151MF86_ALLMI
Myomegalin
CDK5RAP2 Y1Q_0005625
1,817Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A151MFA1A0A151MFA1_ALLMI
CDK5 regulatory subunit-associated ...
CDK5RAP2 Y1Q_0005625
1,967Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AKHW03006215 Genomic DNA Translation: KYO23190.1

NCBI Reference Sequences

More...
RefSeqi
XP_006269512.2, XM_006269450.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
102571950

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
amj:102571950

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AKHW03006215 Genomic DNA Translation: KYO23190.1
RefSeqiXP_006269512.2, XM_006269450.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi102571950
KEGGiamj:102571950

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55755

Phylogenomic databases

KOiK16542
OrthoDBi1046642at2759

Family and domain databases

InterProiView protein in InterPro
IPR012943 Cnn_1N
PfamiView protein in Pfam
PF07989 Cnn_1N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A151MFM6_ALLMI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A151MFM6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 8, 2016
Last sequence update: June 8, 2016
Last modified: January 16, 2019
This is version 12 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health

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