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Entry version 9 (31 Jul 2019)
Sequence version 1 (08 Jun 2016)
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Protein
Submitted name:

Receptor-type tyrosine-protein phosphatase S

Gene
N/A
Organism
Fundulus heteroclitus (Killifish) (Mummichog)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Receptor-type tyrosine-protein phosphatase SImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFundulus heteroclitus (Killifish) (Mummichog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8078 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesFundulidaeFundulus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1290 – 1314HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini51 – 141Ig-likeInterPro annotationAdd BLAST91
Domaini153 – 236Ig-likeInterPro annotationAdd BLAST84
Domaini255 – 337Ig-likeInterPro annotationAdd BLAST83
Domaini344 – 434Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini439 – 533Fibronectin type-IIIInterPro annotationAdd BLAST95
Domaini537 – 627Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini632 – 734Fibronectin type-IIIInterPro annotationAdd BLAST103
Domaini739 – 847Fibronectin type-IIIInterPro annotationAdd BLAST109
Domaini848 – 946Fibronectin type-IIIInterPro annotationAdd BLAST99
Domaini947 – 1042Fibronectin type-IIIInterPro annotationAdd BLAST96
Domaini1047 – 1131Fibronectin type-IIIInterPro annotationAdd BLAST85

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni422 – 442DisorderedSequence analysisAdd BLAST21

Keywords - Domaini

RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 8 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 11 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 7 hits
PF07679 I-set, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 8 hits
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 3 hits
SSF49265 SSF49265, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 8 hits
PS50835 IG_LIKE, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

A0A146RXZ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSCKPGRVP ARSRRPVLGF CLRPSPLCLT LPLIIFLTRP WGSVCEALAP
60 70 80 90 100
PRFTKIPTDQ TGVSGGVASF VCQATGNPKP VVYWNKKGKK VNSQRIETIE
110 120 130 140 150
FDEGAGAVLR IQPLRAPRDE NVYECVARNN QGDIAITAKL AIIREDLLPF
160 170 180 190 200
GFPSIDMGPQ LKVVERTKTA TMLCAASGIP DPEISWFKDF LPVDPSLSQG
210 220 230 240 250
RIKQLRSGAL QIENSEETDQ GKYECVATNT QGVRYSSPAN LYVRGAPDTL
260 270 280 290 300
RRVPPRFSIL PSNHEIMPGG SVNITCVAVG SPMPYVKWML GIEDLTPEDE
310 320 330 340 350
MPIGRNVLEL NGVRESANYT CVAMSSLGII EATAQVLVKT LPKPPGTPIV
360 370 380 390 400
TETTATSVTI TWDSGNPDPV SYYIIQYRAK GPESKYETVD SITTTRYSIG
410 420 430 440 450
GLYPNTEYEI RVSAFNSIGQ GPPSARVEAR TGEQAPASPP RNVQAHVISE
460 470 480 490 500
NTVMVRWEEP EEPNGQVKGY RVYYTMDPSR AINEWQIHNV QDSIITTIQN
510 520 530 540 550
LATSETYTIQ VLAFTSVGDG PFSDPVHVKV LRGVPGQPGK FKVGKVTDTS
560 570 580 590 600
IELTWEPAYE KEGIISYELR YKEGNLGTQM KKTFGPTKSY VVEGLRPNTE
610 620 630 640 650
YRFSLAAISN KGIGAFTNEI SERTLQAKPS APPQEIKCKT TSSTSFLVSW
660 670 680 690 700
RPPPLKSQNG DLTGYRVRYQ VVGPSEGASD DTEPMEELLD SPADERLLLE
710 720 730 740 750
RLEKWTQYRI TVSASTEVGP GPESEPLICR TDEDVPGAAP RRVEVEVLNS
760 770 780 790 800
TALKVMWRSV TPGKQNGQIR GYQVHYVRVE NGESRGLPLI KDVMLADAQW
810 820 830 840 850
ETDDTAEYEM VIDGLKPETT YSVTVAAYTT KGDGARSKPK VVVTKGAVPG
860 870 880 890 900
PPYLSVAQDS KTSAVVHWDP PDLINGMDLQ GYRLQFGRKD VSPLATLEFA
910 920 930 940 950
PQERQFSVGN IHRGATYLFK ISAQSRGGFG EEAVAELTVP ENTPGGYPQI
960 970 980 990 1000
NEGTTVTCCS VLLSWSPPVL AERNGVITEY TLAFKEAGTR ETPQELRIPP
1010 1020 1030 1040 1050
NLSSYELNSL KPNSAYDVKI RAHTSVGPGP YSPPIQYRTG AVDTADVPKN
1060 1070 1080 1090 1100
FTVKWATKTT VVLGWKFANK GSPYKCTIEY NRQKMDVDAT KLKAYITGLR
1110 1120 1130 1140 1150
HNSTYEFRVT CQESKEGGPR HRVVARTAPL ILVKKPKLDI YAEPENMLTM
1160 1170 1180 1190 1200
SFPPLNNKDV KNYYVVVVPL KTTSGTVKNL KNPDEMDIEE LLRDVIPKRR
1210 1220 1230 1240 1250
SRRQLAQLDQ RSAYITACFK QLPSIFTVGS DHRQSSCENK PLEPGQEYVF
1260 1270 1280 1290 1300
FLLAELNATV GRMFATSPYT DTVITPELVM DPLPIEPSDG LIWVVGPVLA
1310 1320 1330 1340 1350
VVFIIGIVIS ILLLKNRKRK ESEPRTKCLL NNADITPHHP TDPVEMRRIN
1360 1370 1380 1390
FQTAGMMNHP PIPISELAEH TELLKANDNL KLSQEYESID PGQQ
Length:1,394
Mass (Da):154,044
Last modified:June 8, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE43C0ACF69339E1A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1394Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
GCES01113107 Transcribed RNA Translation: JAQ73215.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GCES01113107 Transcribed RNA Translation: JAQ73215.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

CDDicd00063 FN3, 8 hits
Gene3Di2.60.40.10, 11 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF00041 fn3, 7 hits
PF07679 I-set, 2 hits
SMARTiView protein in SMART
SM00060 FN3, 8 hits
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
SSF49265 SSF49265, 5 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 8 hits
PS50835 IG_LIKE, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A146RXZ0_FUNHE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A146RXZ0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 8, 2016
Last sequence update: June 8, 2016
Last modified: July 31, 2019
This is version 9 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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