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Protein

UDP-glucose 6-dehydrogenase

Gene
N/A
Organism
Fundulus heteroclitus (Killifish) (Mummichog)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate.UniRule annotation

Catalytic activityi

UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36NADUniRule annotation1
Binding sitei41NADUniRule annotation1
Binding sitei166NADUniRule annotation1
Binding sitei261SubstrateUniRule annotation1
Active sitei277NucleophileUniRule annotation1
Binding sitei347NADUniRule annotation1
Binding sitei445SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 16NADUniRule annotation6
Nucleotide bindingi89 – 93NADUniRule annotation5
Nucleotide bindingi130 – 131NADUniRule annotation2
Nucleotide bindingi277 – 280NADUniRule annotation4

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucose 6-dehydrogenaseUniRule annotation (EC:1.1.1.22UniRule annotation)
OrganismiFundulus heteroclitus (Killifish) (Mummichog)Imported
Taxonomic identifieri8078 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataOvalentariaAtherinomorphaeCyprinodontiformesFundulidaeFundulus

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini333 – 450UDPG_MGDP_dh_CInterPro annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni162 – 166Substrate bindingUniRule annotation5
Regioni221 – 225Substrate bindingUniRule annotation5
Regioni268 – 274Substrate bindingUniRule annotation7
Regioni339 – 340Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.UniRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028356 UDPglc_DH_euk
PANTHERiPTHR11374 PTHR11374, 1 hit
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500133 UDPglc_DH_euk, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit

Sequencei

Sequence statusi: Complete.

A0A146NPD0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFKIKRICCI GAGYVGGPTC SVIAQMCPEI TVTVVDVNES RIKAWNSDTL
60 70 80 90 100
PIYEPGLKEV VESCRGRNLF FSTDIPSAIR DADLVFISVN TPTKTYGMGK
110 120 130 140 150
GRAADLKFIE SCARQIVEVS DGYKIVTEKS TVPVRAAESI RRMLSAARTK
160 170 180 190 200
PSLNLQVLSN PEFLAEGTAV RDLKEPDRVL IGGDETPEGQ RAIRALCAVY
210 220 230 240 250
EHWVPKSRII TTNTWSSELS KLAANAFLAQ RISSINSISA LCEATGADVE
260 270 280 290 300
EVAKAIGMDQ RIGSKFLKAS VGFGGSCFQK DVLNLVYLCE ALNLPEVASY
310 320 330 340 350
WQQVIDMNEY QRRRFACRII DCLFNTVTGK KIALLGFSFK KDTGDTRESS
360 370 380 390 400
SIYISKYLMD EGAKLFIYDP KVLKEQIIHD LYQPSISEDN PERVSELVTV
410 420 430 440 450
TRDPYEACQS AHALVICTEW DMFRELDYEK IYKKMLKPAF IFDGRRVLDH
460 470 480 490
LHAELQSIGF QIETIGKKVT SARIPYTPAI VGPRTAPTEP PTKKAKA
Length:497
Mass (Da):55,305
Last modified:June 8, 2016 - v1
Checksum:i4E181967EAD31CD9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GCES01152639 Transcribed RNA Translation: JAQ33683.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GCES01152639 Transcribed RNA Translation: JAQ33683.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR036291 NAD(P)-bd_dom_sf
IPR017476 UDP-Glc/GDP-Man
IPR014027 UDP-Glc/GDP-Man_DH_C
IPR036220 UDP-Glc/GDP-Man_DH_C_sf
IPR014026 UDP-Glc/GDP-Man_DH_dimer
IPR001732 UDP-Glc/GDP-Man_DH_N
IPR028356 UDPglc_DH_euk
PANTHERiPTHR11374 PTHR11374, 1 hit
PfamiView protein in Pfam
PF00984 UDPG_MGDP_dh, 1 hit
PF03720 UDPG_MGDP_dh_C, 1 hit
PF03721 UDPG_MGDP_dh_N, 1 hit
PIRSFiPIRSF500133 UDPglc_DH_euk, 1 hit
PIRSF000124 UDPglc_GDPman_dh, 1 hit
SMARTiView protein in SMART
SM00984 UDPG_MGDP_dh_C, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
SSF52413 SSF52413, 1 hit
TIGRFAMsiTIGR03026 NDP-sugDHase, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A146NPD0_FUNHE
AccessioniPrimary (citable) accession number: A0A146NPD0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 8, 2016
Last sequence update: June 8, 2016
Last modified: October 10, 2018
This is version 9 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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