Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Geobacillus subterraneus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotationSAAS annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotationSAAS annotation (EC:1.4.4.2UniRule annotationSAAS annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
ORF Names:GS3922_04025Imported
OrganismiGeobacillus subterraneusImported
Taxonomic identifieri129338 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus
Proteomesi
  • UP000076226 Componenti: Chromosome

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK00282

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

A0A146CXJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHRYLPMTE EDKQEMLKTI GVASIDELFA DIPEQVRFRG ELNVKPAKSE
60 70 80 90 100
PELWKELSAL ADKNANAKQH VSFLGAGVYD HYIPAVVDHV LMRSEFYTAY
110 120 130 140 150
TPYQPEISQG ELQAIFEFQT MVCELTGMDV ANSSMYDGGT SLAEAVLLSA
160 170 180 190 200
AHTKRNKVLL SSAVHPQYRE VVRTYAKGQQ LEVKEIPYNG GVTDLEALAA
210 220 230 240 250
EMGDDVACVV IQYPNFFGQI EPLKAIEPLV HEKKSLFVVA SNPLALGVLT
260 270 280 290 300
PPGAFGADIV VGDMQPFGIP MQFGGPHCGY FAVKAPLMRK IPGRLVGQTT
310 320 330 340 350
DEDGRRGFVL TLQAREQHIR RDKATSNICS NQALNALAAS VALSALGKRG
360 370 380 390 400
VKEMAAMNMQ KAHYAKSELE KRGLLSPFAG PFFNEFVIRL GQPVDDVNAR
410 420 430 440
LLKKGIIGGY DLGFDYPELV NHMLIAVTEL RTKEEIDRFV NELGDCHA
Length:448
Mass (Da):49,373
Last modified:June 8, 2016 - v1
Checksum:iE47126CC4DEE1EB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP014342 Genomic DNA Translation: AMX82914.1
RefSeqiWP_063165291.1, NZ_LWHE01000115.1

Genome annotation databases

EnsemblBacteriaiAMX82914; AMX82914; GS3922_04025
GeneIDi32408212
KEGGigsr:GS3922_04025

Entry informationi

Entry nameiA0A146CXJ5_9BACI
AccessioniPrimary (citable) accession number: A0A146CXJ5
Entry historyiIntegrated into UniProtKB/TrEMBL: June 8, 2016
Last sequence update: June 8, 2016
Last modified: April 25, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health