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Entry version 14 (08 May 2019)
Sequence version 1 (08 Jun 2016)
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Protein

Nonribosomal peptide synthetase TES

Gene

TES

Organism
Alternaria alternata (Alternaria rot fungus) (Torula alternata)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of the phytotoxin tentoxin, an inhibitor the F1-ATPase activity of chloroplasts, resulting in chlorosis in sensitive plants (PubMed:27490569, PubMed:7881545). Tentoxin is a cyclic tetrapeptide that consists of four amino acid residues: glycine (Gly), alanine (Ala), leucine (Leu), and dehydrophenylalanine (DPhe) (PubMed:27490569, PubMed:7881545). In addition, both the Ala and DPhe residues are N-methylated (PubMed:27490569, PubMed:7881545). The nonribosomal peptide synthetase TES assembles tentoxin from the four substrate amino acids (PubMed:27490569). The adenylation domains of each of the 4 modules are responsible for the activation of Gly, Ala, Leu and DPhe, respectively (PubMed:27490569). In addition, the N-methyltransferase domains in the second and fourth modules of TES could be responsible for N-methylation of Ala and DPhe residues (PubMed:27490569). Finally, the condensation domain located in the termination module probably catalyzes the formation of the intramolecular macrocyclization and then the release of tentoxin (PubMed:27490569). The cytochrome P450 monooxygenase TES1 is predicted to be involved in the formation of DPhe (PubMed:27490569).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Phytotoxin biosynthesis

This protein is involved in Phytotoxin biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Phytotoxin biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Ligase
Biological processVirulence

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nonribosomal peptide synthetase TES1 Publication (EC:6.3.2.-1 Publication)
Alternative name(s):
Tentoxin synthase1 Publication
Short name:
TES1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TES1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAlternaria alternata (Alternaria rot fungus) (Torula alternata)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5599 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeAlternariaAlternaria sect. AlternariaAlternaria alternata complex

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Impairs the production of tentoxin (PubMed:27490569).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004389871 – 5161Nonribosomal peptide synthetase TESAdd BLAST5161

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei606O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2102O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3176O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4680O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A144KPJ6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini569 – 645Carrier 1PROSITE-ProRule annotation1 PublicationAdd BLAST77
Domaini2068 – 2141Carrier 2PROSITE-ProRule annotation1 PublicationAdd BLAST74
Domaini3139 – 3215Carrier 3PROSITE-ProRule annotation1 PublicationAdd BLAST77
Domaini4643 – 4725Carrier 4PROSITE-ProRule annotation1 PublicationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni37 – 436Adenylation 1Sequence analysis1 PublicationAdd BLAST400
Regioni659 – 1098Condensation 1Sequence analysis1 PublicationAdd BLAST440
Regioni1122 – 1522Adenylation 2Sequence analysis1 PublicationAdd BLAST401
Regioni1630 – 1742Methyltransferase (M) domain 1Sequence analysis1 PublicationAdd BLAST113
Regioni2179 – 2593Condensation 2Sequence analysis1 PublicationAdd BLAST415
Regioni2614 – 3010Adenylation 3Sequence analysis1 PublicationAdd BLAST397
Regioni3232 – 3668Condensation 3Sequence analysis1 PublicationAdd BLAST437
Regioni3694 – 4098Adenylation 4Sequence analysis1 PublicationAdd BLAST405
Regioni4203 – 4329Methyltransferase (M) domain 2Sequence analysis1 PublicationAdd BLAST127
Regioni4785 – 5093Condensation 4Sequence analysis1 PublicationAdd BLAST309

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module (PubMed:27490569). Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product (PubMed:27490569). Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme (PubMed:27490569). Occasionally, methyltransferase domains (responsible for amino acid methylation) are present within the NRP synthetase (PubMed:27490569). TES has the following architecture:A-T-C-A-M-T-C-A-T-C-A-M-T-C (PubMed:27490569).1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthase family.Curated

Keywords - Domaini

Repeat

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 4 hits
3.30.559.10, 4 hits
3.40.50.12780, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071 AA_adenyl_domain
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR029063 SAM-dependent_MTases

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501 AMP-binding, 4 hits
PF00668 Condensation, 4 hits
PF00550 PP-binding, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823 PKS_PP, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336 SSF47336, 4 hits
SSF53335 SSF53335, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733 AA-adenyl-dom, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 4 hits
PS50075 CARRIER, 4 hits
PS00012 PHOSPHOPANTETHEINE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A144KPJ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGSLLFDVN KLDVEKIWER NRGPLRAVNR CVHSLYEEQA IARPNACAIH
60 70 80 90 100
AWDGNMTYEQ LNQHSTRLAS YLVTQGIGTE VMVPLCFEKS IWAIVAMLAV
110 120 130 140 150
LKAGAAFVPL DPMHPRARHE EIFKQTNAKL VLTSVQHAAL WPNSGLQFLA
160 170 180 190 200
IDKTFVDQLP WETKIRSKVK PIDAVYVMFT SGSTGVPKGV VLEHRAIATS
210 220 230 240 250
CLAHGMEMKL GSDSRALQFA AYTFDICIAE IFTTLIFGGC VCVPSEDDRR
260 270 280 290 300
NALSEVINNN NINWAQLTPT VARLLDPSTV PSLRVLVLGG ERVDEADWKR
310 320 330 340 350
WGDDIVKVNV YGPTECSIWC TSYSNTDREF RSGTIGTSMA SFSWVTDPED
360 370 380 390 400
HNKLVPFGTI GELLIEGPIL ARGYLNDISK TEAVFVDGPL WLRQGNRNDE
410 420 430 440 450
STRRQGRLYK TGDLVYYDAD GNLVYAGRKD SQTKVRGQRI ELGEIEHHLN
460 470 480 490 500
QCMSGIKQVA AEVILPSGDQ AKAMVAAFVQ LSEEPRHALV QQTSNGDLEV
510 520 530 540 550
RVIFPTYLDE LLVQCLPKDM VPEVYFAVAE LPLTTSAKVD RQKLRKIGAS
560 570 580 590 600
FSAQQLAQLR TYSDDPKRQP ETEKEQILHH LWAQVLSIDA SSIGMDDSFF
610 620 630 640 650
DLGGDSIAAM KLVGEARRSG IYITVAVVFQ NPTLDKLTSA AIPSVDVSNT
660 670 680 690 700
TIPPVGHDGH VAQSFAQGRM WFLEELHPGL TWYLMPVVVR MRGPLELTAL
710 720 730 740 750
QSALNAIESR HETLRTTFET IGDTSMQLVH PYHAKELSII DIDIKSLEEV
760 770 780 790 800
LHRDQISPFD LRKEAGLRVS IYRIGSEEHV LSVIMHHIIS DGWSTDVFTR
810 820 830 840 850
ELGAFYSASI RGHDPLVQVQ PLPIQYRDFS VWQRQQAQID KHRSQLNYWF
860 870 880 890 900
NVLNTSRPAE LLCDKARPAA LSGEASKQTI QIDGPLYIQL LQFCKAKGVT
910 920 930 940 950
KFMVLFAAFR ATHFRLTGQN DATIGTVNAN RDRWELKDMI GFFVNLQCLR
960 970 980 990 1000
TTIDADESFE ELVQQVYEAT IASLANADVP FENIVSKLKN SRDLSRHPLV
1010 1020 1030 1040 1050
QLVFAMHSQR NLGQLKLEGL ETESLDNAPK SRFDLEFHFF QQEDSLKGEV
1060 1070 1080 1090 1100
VYSTDIYSPE AIDNMLSIFQ IVLEGCLQEP KAAIASLSLL CDVELSKLNS
1110 1120 1130 1140 1150
MGLIQVEKTD YPRESSVVDL FRQQTSLCPS RIAVKDASVT MTYTQLDKES
1160 1170 1180 1190 1200
DILAQWLAKQ SLAPETLVSV LAGRSCQTIV AFLAILKAGL AYLPFDVRVP
1210 1220 1230 1240 1250
AKRMSTILGS LSGPKFVLLG EDVQPPYVDI SDIRFIRITE ALDEQTHEGS
1260 1270 1280 1290 1300
ASRDIVKPTA NSLAYVMFTS GSTGQPKGAM IEHRGIVRLV RDNNFVQHLP
1310 1320 1330 1340 1350
ASPVMAHMTN LAFDVSTWEI YASLLQGGTL VCIDRLTVLD PEAVLRTFRQ
1360 1370 1380 1390 1400
EHVSTAFMTP SLFRTYVQQL PALFAGLDML CVGGEALHSN DILSMTTLRT
1410 1420 1430 1440 1450
GKIINGYGPT ENTTFNTTFV LSREGQYPNG VPIGRALSNS GAYVMDLKQQ
1460 1470 1480 1490 1500
LVPLGVVGEL VVTGDGLARG YTDLERNIYR FITVQIGGEV VKAYRTGDSV
1510 1520 1530 1540 1550
RYRPADGQLE YFGRMDGQVK IRGHRIELGE IEHVLRSHGS VREAVAVVQQ
1560 1570 1580 1590 1600
QQNADEAARL AAFVTVYEGD ELVEEKPSGI DESEHVDVWE DQFDSKVYTP
1610 1620 1630 1640 1650
ISKVLPEAIG RDFIGWTSMY DGSAIDKVEM NEWLDDTIDT MLNGHPPGKV
1660 1670 1680 1690 1700
LEVGTGTGMV LFNLGDGLES YVGLDPSSRA VEFVKDTVRS VPTLADKVRV
1710 1720 1730 1740 1750
YKATATEIDR LEPIDASLIV INSVIQYFPS LEYLFKTTQQ LLGLESVSTI
1760 1770 1780 1790 1800
FFGDVRSYAL HREFLATRAM FMAGDSADRA EVSRMITDME LVEKELLVDP
1810 1820 1830 1840 1850
AFFTALPERL PDQVEHVEIL PKKMKATNEL SCYRYAAVIH VKPRDGRKQE
1860 1870 1880 1890 1900
QRIRHVGHDE WIDFREHKLD RQSLLAQLQS NPRPSTMAVS NIPYSKTIVS
1910 1920 1930 1940 1950
RCLIESIDNA VAELSDPQDW YSSVCQRAQC SSSMSATDLY ELAKEANCRV
1960 1970 1980 1990 2000
EVSWSRQHSQ CGGIDAIFHR YPPRGGENRV MFQFPTDHAE RPLHTLSSMP
2010 2020 2030 2040 2050
LRQQTLQRIQ GQLQEMLDAQ LPAYMVPQTV TFLETMPTNQ NGKIDRNALT
2060 2070 2080 2090 2100
QRTEIQVAKG QEFQRELTRA ESKIQQLIAR VLRIDSDRIG LDDSFFQLGG
2110 2120 2130 2140 2150
DSIAAMKLVA LARDEDIRLT VAKIFQYPKL IQLAAVAQEH VYVPNDNIVP
2160 2170 2180 2190 2200
FSLLDDEVDA TQTHHEVAVK CAIDRGIIED IYPCSPLQEG LMSLTVKRPG
2210 2220 2230 2240 2250
DYIMQTVLEL REEVDETAFK IAWEKTVQSF QILRTRIVIH ETLGLLQAVI
2260 2270 2280 2290 2300
AEKIKWADAD DLATYLARDK LSSMQLGKPL ARYGLVRDTR REKKWFVWTI
2310 2320 2330 2340 2350
HHAIYDGWAL NHISVLCKQH TMAGKPGKQV GFNSFIKYLR QMDEDALAEY
2360 2370 2380 2390 2400
RRTTLSDCDA NVFPPLVSGV QQPVADATAE YCCPPLPKRT SNTTISTLVR
2410 2420 2430 2440 2450
AAWAIVASGY TSSDDVVFGA TVTGRNAPVA GIESLVGPVI ATVPVRIRLQ
2460 2470 2480 2490 2500
RDSTILEFLE TVQKQATEMI PFEQTGLQRI AKLGPDTEHA CNFQTLLIVQ
2510 2520 2530 2540 2550
PAEDAFQSDD MFGTWEFGSG LQDFTTYGLM VQCKLAKEGV KITASFDARL
2560 2570 2580 2590 2600
VEQWQVERML GQLSFVMQQL ARGDSRTRVM DIGMLTQDDE QQLWMWNQRL
2610 2620 2630 2640 2650
PPAIDRCVHD LYSDQAKSRP EADAICAWDG VMTYKELDER SSRLATYLVD
2660 2670 2680 2690 2700
IGVKPETIVP LCFEKSMWMV VAMLAVLKAG GAFAPLDPSH PVSRHRDIFT
2710 2720 2730 2740 2750
QTKANMMLTS SQYANLWSEY IPTVVEITGH FIDQLTTNPY STETAVQPGN
2760 2770 2780 2790 2800
TAYVIFTSGS TGVPKGVQME HKAVSTSCSC QGPALGITED TRVLQFAAYT
2810 2820 2830 2840 2850
FDACILEIIT TLLHGACICI PSETQRRDHL VNTINTMKVT WALLTPAVAR
2860 2870 2880 2890 2900
ILDPQKIVSL KTLVLGGEKV NGSDCDTWSG RVRLINAYGP TECCVSCVAS
2910 2920 2930 2940 2950
PDMKGLDPEP IGKPIASIGW VTNPNDHNRL APLGAVGELL VEGPNLARGY
2960 2970 2980 2990 3000
LDDAKKTETA FVHDPLWLLR GCEGYSGRRG RLYKTGDLVY HTSDGDLVYV
3010 3020 3030 3040 3050
GRKDGQVKVR GQRIELAEIE ICLYQHISDI KEIAVELISP TGGKPMIAAF
3060 3070 3080 3090 3100
LKANPELLND KLSDGDSGVY VVYPARVDNE LSQRLPRNMV PEVYFALTEF
3110 3120 3130 3140 3150
PISTSGKINR RRLREIGGSF STDQLARLRT QKNESSDRKP ETKHEMALQK
3160 3170 3180 3190 3200
LWAQVLNIEA TSIGLNDSFF QLGGDSISAM KLVSEARNVD LVFSVQDVFQ
3210 3220 3230 3240 3250
VQRLGRLANR LVDPPTSSHS AITKIDHQRP VLQSFAQGRL WFLEQLHPGL
3260 3270 3280 3290 3300
DWYLMHLAVR IKGPVQLPAL QAALQAIEHR HETLRTTFST NNGESLQEVH
3310 3320 3330 3340 3350
PFCGGRELNV IDVGSNDDKI LLEALERDQK TPFNLRYEPG WRISIYRIND
3360 3370 3380 3390 3400
VSHVLSIVMH HIVSDGWSVD VLKKELSALY ASAIRNEDPI FCLPPLPIQY
3410 3420 3430 3440 3450
RDFSVWQRLP EQAQEHRRQL DYWINQLDGS RPAEFLYDKP RPTTLSGKAG
3460 3470 3480 3490 3500
TQRLNISHKL YNRLQIFARQ RGMTPFVVLL AVFRATHYRL TNQDDATIAV
3510 3520 3530 3540 3550
PNANRSRPEL GDLIGFFVNI QCMRMKIQDE TFEELLQHAY KTVVDSLANQ
3560 3570 3580 3590 3600
DVPFESIVSA LQGDRDSSRN PLAQVAFAVH SQQDIGKLDF EGVGTEAIEG
3610 3620 3630 3640 3650
LATSRFDLEF HFFQEKNGFQ GYIYFSEELF VPETIYSLAS VFTSILDNCL
3660 3670 3680 3690 3700
DKPETQIAVV PLMTVEAHTQ LDQMGLLRMH QTAYPRNSSI VDVFRQQAAM
3710 3720 3730 3740 3750
QPSRVAVKDT STDLTYAQLD SQSEKLAKFL ATKSFAPETA VGVLAHRCCQ
3760 3770 3780 3790 3800
AIVAFIGILK AGLAYLPFDH KAPEKRMESI FSTIEGNKLV LIGPNISLPG
3810 3820 3830 3840 3850
TGPKDVEFAY IPDILDADED FEFTRSELDP TLRPTASSLA YILFTSGSTG
3860 3870 3880 3890 3900
QPKGVMVEHR GIVRLAQHDQ MEHFKSSGAM AHMANLAFDG SSWEIYTCLL
3910 3920 3930 3940 3950
NGGTLVCIDA TTVLDQDALL RAFTESQIRI AFITPALLNY ILAESPDTIG
3960 3970 3980 3990 4000
NLDTLLVAGD RADVDDVFRA RDLVRNKVVA NAYGPTENSV MSTLYILSED
4010 4020 4030 4040 4050
ENCVNGVPIG RPISNSAAYV MDPEQNLVPL GVFGELVVTG DGVARGYTDP
4060 4070 4080 4090 4100
RRNVDRFVTV TIGHQTMRAY RTGDYVRQRP RDGEMEFFGR IDGQVKIRGN
4110 4120 4130 4140 4150
RVELGEIETV LRGHGLVRDA VVVAEQRKDK NQRLFGYITL KEDFEMLSAQ
4160 4170 4180 4190 4200
NSDDDQIQHV NAWEHRFNTE TYAQIVGIQS ETVGQDFIGW TSMYDGTDID
4210 4220 4230 4240 4250
KTEMKEWLEE TIGSIHDKVG GQLGNVLEIG SGSGMILFNL GDSLKHYTGF
4260 4270 4280 4290 4300
EPSRKAVEFV TGTARSIPSL ANKVEMYKAT AADISKVDQP LQADLVVLNS
4310 4320 4330 4340 4350
VVQYFPSQGY LFNVVRDLLK VDGVKTLFFG DIRSYALRRE FYAARALFMA
4360 4370 4380 4390 4400
GERASQKDLR RLVEDMEQIE QELLVDPGFF TSLTHRLPDL VQHVEIQPKR
4410 4420 4430 4440 4450
MRATNELSSY RYTAVVYSRS REPPCGGLRT IPDNEWIDFQ EQGLNNDSLQ
4460 4470 4480 4490 4500
QRIKDVSSTH PLAVSNISHT KTLFGNCLLG ALGDGKARKP VHTDWTAHIN
4510 4520 4530 4540 4550
RQAKGIPSLS AVDLDEMAKA AGCQVRISWN RQYSQHGGLD AIFYPRQING
4560 4570 4580 4590 4600
GSDKAGVMFS FPTDHAERRR QTLSNKPMRQ QLVKEVQQQL DELVKVQLPS
4610 4620 4630 4640 4650
YMVPQSIQVL NQLPINQNGK VDRKALIQRT RTQTEVSQGG LQRELSTAEL
4660 4670 4680 4690 4700
KVQRILSRVL GIEASRMGLE DSFFQLGGDS IAAMKIVAAA REEEIHLTIA
4710 4720 4730 4740 4750
NIFQHPKLVN LATVAQFSQH EGEQKSIQPF SLLSTTQRDY LLHAIPENTS
4760 4770 4780 4790 4800
NVNGNDIIDI LPTTWMQNLF ISRGVNIQPL AFNYFFLNLG TRVDASRLRS
4810 4820 4830 4840 4850
SIPTLVQQFS ILRTKFVYVD GVLWQTVLRK PHVPFTEFHL DMSLEEAADT
4860 4870 4880 4890 4900
VCLEDSRTTD PLELATAFML IRGTSNEHLL AIRITHAQYD GVCFPSFVKA
4910 4920 4930 4940 4950
LFAIYSGKSV EPAHNHSTYL AYTRERKSVS ALHWRDVLHG SRMTKATPLL
4960 4970 4980 4990 5000
SPSIRHGMIP VEVQTESIIG MPHVPTGLTL ASLVSAAWAK VLSQITGEED
5010 5020 5030 5040 5050
VVYGYMVAGR NANIPAITKI VGPCLNIIPV RARLHAKTTS TELIRSIQEQ
5060 5070 5080 5090 5100
YIALGEADSM GFDEIVRTST DWPADTEYDS VFQHQNLNEH PEFDFEGTSS
5110 5120 5130 5140 5150
RLHWFQNPDS VPCILTVVSY PLEDGLRIVV RGNEHIITPE SAERINKLLC
5160
ETIGALSSSL Q
Length:5,161
Mass (Da):576,696
Last modified:June 8, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i66193A5E4EA480FF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
KT947104 Genomic DNA Translation: AMT84997.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KT947104 Genomic DNA Translation: AMT84997.1

3D structure databases

SMRiA0A144KPJ6
ModBaseiSearch...

Family and domain databases

Gene3Di1.10.1200.10, 4 hits
3.30.559.10, 4 hits
3.40.50.12780, 4 hits
InterProiView protein in InterPro
IPR010071 AA_adenyl_domain
IPR036736 ACP-like_sf
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR042099 AMP-dep_Synthh-like_sf
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00501 AMP-binding, 4 hits
PF00668 Condensation, 4 hits
PF00550 PP-binding, 4 hits
SMARTiView protein in SMART
SM00823 PKS_PP, 4 hits
SUPFAMiSSF47336 SSF47336, 4 hits
SSF53335 SSF53335, 2 hits
TIGRFAMsiTIGR01733 AA-adenyl-dom, 4 hits
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 4 hits
PS50075 CARRIER, 4 hits
PS00012 PHOSPHOPANTETHEINE, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTES_ALTAL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A144KPJ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2017
Last sequence update: June 8, 2016
Last modified: May 8, 2019
This is version 14 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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