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UniProtKB - A0A143ZZK9 (A0A143ZZK9_PLAF7)
Protein
Submitted name:
Non-SERCA-type Ca2+ -transporting P-ATPase
Gene
PF3D7_1211900
Organism
Plasmodium falciparum (isolate 3D7)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: InterPro
- hydrolase activity Source: UniProtKB-KW
- P-type calcium transporter activity Source: GO_Central
- P-type ion transporter activity Source: GO_Central
GO - Biological processi
- calcium ion transmembrane transport Source: GO_Central
- cellular calcium ion homeostasis Source: GO_Central
- ion transmembrane transport Source: GO_Central
Keywordsi
Molecular function | HydrolaseImported, TranslocaseARBA annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | ORF Names:PF3D7_1211900Imported |
Organismi | Plasmodium falciparum (isolate 3D7)Imported |
Taxonomic identifieri | 36329 [NCBI] |
Taxonomic lineagei | Eukaryota › Sar › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodiidae › Plasmodium › Plasmodium (Laverania) › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_1211900 |
Subcellular locationi
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 165 – 191 | HelicalSequence analysisAdd BLAST | 27 | |
Transmembranei | 197 – 214 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 357 – 381 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 393 – 419 | HelicalSequence analysisAdd BLAST | 27 | |
Transmembranei | 923 – 944 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 996 – 1023 | HelicalSequence analysisAdd BLAST | 28 | |
Transmembranei | 1201 – 1223 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 1229 – 1250 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 118 – 193 | Cation_ATPase_NInterPro annotationAdd BLAST | 76 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 102 | DisorderedSequence analysisAdd BLAST | 102 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 14 – 37 | Basic and acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 44 – 60 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 61 – 77 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 84 – 100 | Polar residuesSequence analysisAdd BLAST | 17 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
PhylomeDBi | A0A143ZZK9 |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A143ZZK9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSQNNNKQG GQDINNKKDS DDIKPSVSKE DLINSLKNDE LNKNTTMDQN
60 70 80 90 100
DMKKNENMNI KKNEVLNNSN NVEDGDNENS KFMNKSKEGL NNINGEKNDD
110 120 130 140 150
NNSIVKVEES PKSIGYNYYA SESIENLCKE FGLESINTGL NSEQVKINRD
160 170 180 190 200
KYGENFIEKD EVVPVWLIFL SQYCSPVVLL LLVAAVASLA LNEVVEGVAI
210 220 230 240 250
ISIVTLNACL ATYMEKSSGD AIGKLAEMAS PQCTVLRNGQ KVVIPSREVV
260 270 280 290 300
VGDVVLINTG DSISADLRLF DVIELKTNES LLTGESEDIK KTIVADNLST
310 320 330 340 350
PFATNLCFAT TSVTSGSGKG IVISTGLDTQ VGKIASQLKK SSKGSKLTPL
360 370 380 390 400
QVALNKLGGL IGLIAIIVLV VIISLAVIIK YRDPAHADKD PTFVIIIIGV
410 420 430 440 450
GFAVSSIPEG LPMVVTITLS AGAKDMVKKN ANVRKLPAVE TLGCCSVICS
460 470 480 490 500
DKTGTLTEGK MTAINAVTIC KNSSLSDENN KLTKTFDFYP TKGFEPCGGL
510 520 530 540 550
FDSNELTSEK KKEIVIAKNQ NTSYDKVLYN YGNPSNKSVI VDKTRSLMFA
560 570 580 590 600
AYLNSYDTTL SRDPKTLKWG IHGNMSEGPI VVAAAKVGYS FINNPNHKSY
610 620 630 640 650
LDNFQRLDDL EVTFNSSRKM KITFYKLKTV NVFENVYLDK PGKVYTHVAL
660 670 680 690 700
IKGAPDRLLD RSTHLLEETS MKKVQVSWNS TITQEERNVL IKKNLELSQK
710 720 730 740 750
ALRVLSICIK PLTDQNIEEL KKLEDADERL KYVNYDENGG FIPMGYVASF
760 770 780 790 800
DPPRPGVKEA IQTCREAQVK VIMITGDQKP TAVAIGKLIG LIEEKSEQVE
810 820 830 840 850
DINSLAIECS ELHINKNPNE PILPNDQLDE FTDKILIYSR AQPEDKITIV
860 870 880 890 900
QSLKRKGYLV AMTGDGVNDA PALKAADIGV AMGINGTEVA KGASEMILID
910 920 930 940 950
DNFCTVVSAI DVGRTIFSNI QKFVCFLLGT NIGEIIYLSV AIVAQMPFPL
960 970 980 990 1000
EALQILFLNL MTDGCPAVAL SREPPNDDNM KTPPRPKKQP IMTKRWWFYG
1010 1020 1030 1040 1050
ILPHTIFEAL CVLLSLAFSL YICTGFYNLN GIHNLCKTVN LVDVNDANVY
1060 1070 1080 1090 1100
HEYKYFCSSY EYRISTDYVG WVTNVSFWDP QNNEAVNFWG AAKGKVENIN
1110 1120 1130 1140 1150
PLSDIVHPEL RLRMQDGCSG DLTLDENGWC RPKDNKTSDG YNDELEGILK
1160 1170 1180 1190 1200
KGFEDVTAKG SKRGRTMAFI SAVWCEMLRA YTVRSWEPFY KVFNRNMWMH
1210 1220 1230 1240 1250
LACSISATLT FLSTCIPGIT SILNTTCLLW WQYLLAIFWA LLNLFLDEIV
1260
PKVIYRRKYM TIKN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999947 Genomic DNA Translation: CZT99281.1 |
Genome annotation databases
EnsemblProtistsi | CZT99281; CZT99281; PF3D7_1211900 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | LN999947 Genomic DNA Translation: CZT99281.1 |
3D structure databases
SMRi | A0A143ZZK9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 5833.PFL0590c |
Chemistry databases
DrugBanki | DB11638, Artenimol |
Genome annotation databases
EnsemblProtistsi | CZT99281; CZT99281; PF3D7_1211900 |
Organism-specific databases
VEuPathDBi | PlasmoDB:PF3D7_1211900 |
Phylogenomic databases
PhylomeDBi | A0A143ZZK9 |
Family and domain databases
Gene3Di | 3.40.1110.10, 1 hit 3.40.50.1000, 1 hit |
InterProi | View protein in InterPro IPR006068, ATPase_P-typ_cation-transptr_C IPR004014, ATPase_P-typ_cation-transptr_N IPR023299, ATPase_P-typ_cyto_dom_N IPR018303, ATPase_P-typ_P_site IPR023298, ATPase_P-typ_TM_dom_sf IPR008250, ATPase_P-typ_transduc_dom_A_sf IPR036412, HAD-like_sf IPR023214, HAD_sf IPR001757, P_typ_ATPase IPR044492, P_typ_ATPase_HD_dom |
Pfami | View protein in Pfam PF00689, Cation_ATPase_C, 1 hit PF00690, Cation_ATPase_N, 1 hit |
PRINTSi | PR00120, HATPASE |
SFLDi | SFLDF00027, p-type_atpase, 1 hit |
SMARTi | View protein in SMART SM00831, Cation_ATPase_N, 1 hit |
SUPFAMi | SSF56784, SSF56784, 1 hit SSF81653, SSF81653, 1 hit SSF81660, SSF81660, 1 hit SSF81665, SSF81665, 1 hit |
TIGRFAMsi | TIGR01494, ATPase_P-type, 2 hits |
PROSITEi | View protein in PROSITE PS00154, ATPASE_E1_E2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A143ZZK9_PLAF7 | |
Accessioni | A0A143ZZK9Primary (citable) accession number: A0A143ZZK9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 8, 2016 |
Last sequence update: | June 8, 2016 | |
Last modified: | January 19, 2022 | |
This is version 33 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |