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Protein

Thiamine thiazole synthase

Gene

thi4

Organism
Thermococcus peptonophilus
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Cofactori

Fe2+UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in the pathway thiamine diphosphate biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei34NADUniRule annotation1
Binding sitei61NAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei125NAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Metal bindingi153Iron; shared with adjacent protomerUniRule annotation1
Metal bindingi168IronUniRule annotation1
Binding sitei216NAD; via amide nitrogenUniRule annotation1
Binding sitei226GlycineUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi53 – 54NADUniRule annotation2
Nucleotide bindingi151 – 153NAD; shared with adjacent protomerUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseImported, LyaseUniRule annotation
Biological processThiamine biosynthesisUniRule annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotation, NADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00060

Names & Taxonomyi

Protein namesi
Recommended name:
Thiamine thiazole synthaseUniRule annotation (EC:4.-.-.-UniRule annotation)
Gene namesi
Name:thi4UniRule annotation
ORF Names:A0127_02260Imported
OrganismiThermococcus peptonophilusImported
Taxonomic identifieri53952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000073604 Componenti: Chromosome

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the THI4 family.UniRule annotation

Phylogenomic databases

KOiK22699

Family and domain databases

Gene3Di3.50.50.60, 1 hit
HAMAPiMF_00304 Thi4, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002922 Thi4_fam
IPR022828 Thi4_prok
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00292 TIGR00292, 1 hit

Sequencei

Sequence statusi: Complete.

A0A142CTH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREIEISRAI VEAYFNDFLQ NLQLDVAIVG AGPSGMVAGY YLAKGGAKVA
60 70 80 90 100
IFEKKLSVGG GIWGGAMGFN RVVVQESARE VLDEFGVDYR SVGNGLYVLD
110 120 130 140 150
SIELASTLAS KAVKMGVKIF NMVEVEDLVV KDGRVSGLVI NWTPVMMTGL
160 170 180 190 200
HVDPLTVEAK FVIDSTGHGA QISQHLLKRG LIKAIPGEGP MWAEKGEELT
210 220 230 240 250
VEHTKEVFPG LYATGMAANA LAGAPRMGPI FGGMLLSGRK AALEILQKLE

K
Length:251
Mass (Da):26,821
Last modified:June 8, 2016 - v1
Checksum:iB787898C98316EF5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP014750 Genomic DNA Translation: AMQ18076.1
RefSeqiWP_062387444.1, NZ_CP014750.1

Genome annotation databases

EnsemblBacteriaiAMQ18076; AMQ18076; A0127_02260
GeneIDi27139332
KEGGitpep:A0127_02260

Similar proteinsi

Entry informationi

Entry nameiA0A142CTH4_9EURY
AccessioniPrimary (citable) accession number: A0A142CTH4
Entry historyiIntegrated into UniProtKB/TrEMBL: June 8, 2016
Last sequence update: June 8, 2016
Last modified: July 18, 2018
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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