UniProtKB - A0A140VKA0 (A0A140VKA0_HUMAN)
Protein
Submitted name:
Caldesmon 1, isoform CRA_i
Gene
CALD1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- actin binding Source: InterPro
- calmodulin binding Source: InterPro
- myosin binding Source: InterPro
GO - Biological processi
- muscle contraction Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Caldesmon 1, isoform CRA_iImportedSubmitted name: Testis secretory sperm-binding protein Li 227nImported |
Gene namesi | Name:CALD1Imported ORF Names:hCG_17453Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Cytoskeleton
- actin cytoskeleton Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- myofibril Source: UniProtKB-SubCell
Interactioni
GO - Molecular functioni
- actin binding Source: InterPro
- calmodulin binding Source: InterPro
- myosin binding Source: InterPro
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 25 – 94 | DisorderedSequence analysisAdd BLAST | 70 | |
Regioni | 108 – 385 | DisorderedSequence analysisAdd BLAST | 278 | |
Regioni | 432 – 451 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 494 – 538 | DisorderedSequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 25 – 60 | PolyampholyteSequence analysisAdd BLAST | 36 | |
Compositional biasi | 61 – 90 | PolarSequence analysisAdd BLAST | 30 | |
Compositional biasi | 108 – 123 | PolyampholyteSequence analysisAdd BLAST | 16 | |
Compositional biasi | 124 – 140 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 141 – 254 | PolyampholyteSequence analysisAdd BLAST | 114 | |
Compositional biasi | 272 – 385 | PolyampholyteSequence analysisAdd BLAST | 114 |
Family and domain databases
InterProi | View protein in InterPro IPR006017, Caldesmon IPR006018, Caldesmon_LSP |
PANTHERi | PTHR18949, PTHR18949, 2 hits PTHR18949:SF0, PTHR18949:SF0, 2 hits |
Pfami | View protein in Pfam PF02029, Caldesmon, 1 hit |
PRINTSi | PR01076, CALDESMON |
i Sequence
Sequence statusi: Complete.
A0A140VKA0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDDFERRREL RRQKREEMRL EAERIAYQRN DDDEEEAARE RRRRARQERL
60 70 80 90 100
RQKQEEESLG QVTDQVEVNA QNSVPDEEAK TTTTNTQVEG DDEAAFLERL
110 120 130 140 150
ARREERRQKR LQEALERQKE FDPTITDASL SLPSRRMQND TAENETTEKE
160 170 180 190 200
EKSESRQERY EIEETETVTK SYQKNDWRDA EENKKEDKEK EEEEEEKPKR
210 220 230 240 250
GSIGENQIKD EKIKKDKEPK EEVKSFMDRK KGFTEVKSQN GEFMTHKLKH
260 270 280 290 300
TENTFSRPGG RASVDTKEAE GAPQVEAGKR LEELRRRRGE TESEEFEKLK
310 320 330 340 350
QKQQEAALEL EELKKKREER RKVLEEEEQR RKQEEADRKL REEEEKRRLK
360 370 380 390 400
EEIERRRAEA AEKRQKMPED GLSDDKKPFK CFTPKGSSLK IEERAEFLNK
410 420 430 440 450
SVQKSSGVKS THQAAIVSKI DSRLEQYTSA IEGTKSAKPT KPAASDLPVP
460 470 480 490 500
AEGVRNIKSM WEKGNVFSSP TAAGTPNKET AGLKVGVSSR INEWLTKTPD
510 520 530
GNKSPAPKPS DLRPGDVSSK RNLWEKQSVD KVTSPTKV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM005640 mRNA Translation: AEE61237.1 CH471070 Genomic DNA Translation: EAW83834.1 |
RefSeqi | NP_004333.1, NM_004342.6 XP_016868141.1, XM_017012652.1 |
Genome annotation databases
GeneIDi | 800 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM005640 mRNA Translation: AEE61237.1 CH471070 Genomic DNA Translation: EAW83834.1 |
RefSeqi | NP_004333.1, NM_004342.6 XP_016868141.1, XM_017012652.1 |
3D structure databases
SMRi | A0A140VKA0 |
ModBasei | Search... |
Protocols and materials databases
Antibodypediai | 1954, 1263 antibodies |
Genome annotation databases
GeneIDi | 800 |
Organism-specific databases
CTDi | 800 |
Miscellaneous databases
BioGRID-ORCSi | 800, 9 hits in 874 CRISPR screens |
ChiTaRSi | CALD1, human |
GenomeRNAii | 800 |
Gene expression databases
ExpressionAtlasi | A0A140VKA0, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR006017, Caldesmon IPR006018, Caldesmon_LSP |
PANTHERi | PTHR18949, PTHR18949, 2 hits PTHR18949:SF0, PTHR18949:SF0, 2 hits |
Pfami | View protein in Pfam PF02029, Caldesmon, 1 hit |
PRINTSi | PR01076, CALDESMON |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A140VKA0_HUMAN | |
Accessioni | A0A140VKA0Primary (citable) accession number: A0A140VKA0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 8, 2016 |
Last sequence update: | June 8, 2016 | |
Last modified: | February 10, 2021 | |
This is version 36 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |