UniProtKB - A0A140VK70 (A0A140VK70_HUMAN)
Protein
26S proteasome AAA-ATPase subunit RPT1
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.ARBA annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- proteasome-activating ATPase activity Source: InterPro
GO - Biological processi
- protein catabolic process Source: InterPro
Keywordsi
Ligand | ATP-bindingUniRule annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: 26S proteasome AAA-ATPase subunit RPT1ARBA annotationAlternative name(s): 26S proteasome regulatory subunit 7ARBA annotation Proteasome 26S subunit ATPase 2ARBA annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Other locations
- Cytoplasm ARBA annotation
Cytosol
- cytosol Source: HPA
Other locations
- cytoplasmic ribonucleoprotein granule Source: HPA
- proteasome complex Source: UniProtKB-KW
Keywords - Cellular componenti
ProteasomeARBA annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 208 – 347 | AAAInterPro annotationAdd BLAST | 140 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 22 | DisorderedSequence analysisAdd BLAST | 22 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 38 – 65 | Sequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
OMAi | IHANTMN |
OrthoDBi | 571919at2759 |
PhylomeDBi | A0A140VK70 |
Family and domain databases
InterProi | View protein in InterPro IPR005937, 26S_Psome_P45-like IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR027417, P-loop_NTPase IPR035245, PSMC2 |
PANTHERi | PTHR23073:SF13, PTHR23073:SF13, 1 hit |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01242, 26Sp45, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A140VK70-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPDYLGADQR KTKEDEKDDK PIRALDEGDI ALLKTYGQST YSRQIKQVED
60 70 80 90 100
DIQQLLKKIN ELTGIKESDT GLAPPALWDL AADKQTLQSE QPLQVARCTK
110 120 130 140 150
IINADSEDPK YIINVKQFAK FVVDLSDQVA PTDIEEGMRV GVDRNKYQIH
160 170 180 190 200
IPLPPKIDPT VTMMQVEEKP DVTYSDVGGC KEQIEKLREV VETPLLHPER
210 220 230 240 250
FVNLGIEPPK GVLLFGPPGT GKTLCARAVA NRTDACFIRV IGSELVQKYV
260 270 280 290 300
GEGARMVREL FEMARTKKAC LIFFDEIDAI GGARFDDGAG GDNEVQRTML
310 320 330 340 350
ELINQLDGFD PRGNIKVLMA TNRPDTLDPA LMRPGRLDRK IEFSLPDLEG
360 370 380 390 400
RTHIFKIHAR SMSVERDIRF ELLARLCPNS TGAEIRSVCT EAGMFAIRAR
410 420 430
RKIATEKDFL EAVNKVIKSY AKFSATPRYM TYN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM005610 mRNA Translation: AEE61207.1 |
RefSeqi | NP_002794.1, NM_002803.3 |
Genome annotation databases
GeneIDi | 5701 |
KEGGi | hsa:5701 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM005610 mRNA Translation: AEE61207.1 |
RefSeqi | NP_002794.1, NM_002803.3 |
3D structure databases
SMRi | A0A140VK70 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A0A140VK70, 1 interactor |
Protocols and materials databases
Antibodypediai | 16901, 347 antibodies |
Genome annotation databases
GeneIDi | 5701 |
KEGGi | hsa:5701 |
Organism-specific databases
CTDi | 5701 |
Phylogenomic databases
OMAi | IHANTMN |
OrthoDBi | 571919at2759 |
PhylomeDBi | A0A140VK70 |
Miscellaneous databases
BioGRID-ORCSi | 5701, 701 hits in 897 CRISPR screens |
GenomeRNAii | 5701 |
Gene expression databases
ExpressionAtlasi | A0A140VK70, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR005937, 26S_Psome_P45-like IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR027417, P-loop_NTPase IPR035245, PSMC2 |
PANTHERi | PTHR23073:SF13, PTHR23073:SF13, 1 hit |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01242, 26Sp45, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A140VK70_HUMAN | |
Accessioni | A0A140VK70Primary (citable) accession number: A0A140VK70 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 8, 2016 |
Last sequence update: | June 8, 2016 | |
Last modified: | February 10, 2021 | |
This is version 30 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |