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UniProtKB - A0A140VJT8 (A0A140VJT8_HUMAN)
Protein
Ribonuclease inhibitor
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis.
ARBA annotationNames & Taxonomyi
Protein namesi | Recommended name: Ribonuclease inhibitorARBA annotationAlternative name(s): Ribonuclease/angiogenin inhibitor 1ARBA annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
VEuPathDBi | HostDB:ENSG00000023191 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm ARBA annotation
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
CytoplasmARBA annotationInteractioni
Subunit structurei
Forms high-affinity heterodimers with RNASE1, ANG and RNASE2.
ARBA annotationProtein-protein interaction databases
IntActi | A0A140VJT8, 1 interactor |
Family & Domainsi
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
OMAi | GGNDIHA |
OrthoDBi | 710473at2759 |
PhylomeDBi | A0A140VJT8 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR006553, Leu-rich_rpt_Cys-con_subtyp IPR032675, LRR_dom_sf IPR041302, LRR_RI_cap |
Pfami | View protein in Pfam PF13516, LRR_6, 6 hits PF18779, LRR_RI_capping, 1 hit |
SMARTi | View protein in SMART SM00367, LRR_CC, 5 hits |
i Sequence
Sequence statusi: Complete.
A0A140VJT8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLDIQSLDI QCEELSDARW AELLPLLQQC QVVRLDDCGL TEARCKDISS
60 70 80 90 100
ALRVNPALAE LNLRSNELGD VGVHCVLQGL QTPSCKIQKL SLQNCCLTGA
110 120 130 140 150
GCGVLSSTLR TLPTLQELHL SDNLLGDAGL QLLCEGLLDP QCRLEKLQLE
160 170 180 190 200
YCSLSAASCE PLASVLRAKP DFKELTVSNN DINEAGVRVL CQGLKDSPCQ
210 220 230 240 250
LEALKLESCG VTSDNCRDLC GIVASKASLR ELALGSNKLG DVGMAELCPG
260 270 280 290 300
LLHPSSRLRT LWIWECGITA KGCGDLCRVL RAKESLKELS LAGNELGDEG
310 320 330 340 350
ARLLCETLLE PGCQLESLWV KSCSFTAACC SHFSSVLAQN RFLLELQISN
360 370 380 390 400
NRLEDAGVRE LCQGLGQPGS VLRVLWLADC DVSDSSCSSL AATLLANHSL
410 420 430 440 450
RELDLSNNCL GDAGILQLVE SVRQPGCLLE QLVLYDIYWS EEMEDRLQAL
460
EKDKPSLRVI S
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM005477 mRNA Translation: AEE61075.1 |
RefSeqi | NP_002930.2, NM_002939.3 NP_976317.1, NM_203383.1 NP_976318.1, NM_203384.1 NP_976319.1, NM_203385.1 NP_976320.1, NM_203386.2 NP_976321.1, NM_203387.2 NP_976322.1, NM_203388.2 NP_976323.1, NM_203389.2 XP_011518557.1, XM_011520255.1 XP_011518559.1, XM_011520257.2 XP_011518560.1, XM_011520258.2 XP_011518561.1, XM_011520259.2 XP_011518562.1, XM_011520260.2 XP_011518563.1, XM_011520261.2 XP_011518564.1, XM_011520262.2 XP_011518565.1, XM_011520263.1 XP_016873595.1, XM_017018106.1 |
Genome annotation databases
GeneIDi | 6050 |
KEGGi | hsa:6050 |
MANE-Selecti | ENST00000354420.7; ENSP00000346402.2; NM_203387.3; NP_976321.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM005477 mRNA Translation: AEE61075.1 |
RefSeqi | NP_002930.2, NM_002939.3 NP_976317.1, NM_203383.1 NP_976318.1, NM_203384.1 NP_976319.1, NM_203385.1 NP_976320.1, NM_203386.2 NP_976321.1, NM_203387.2 NP_976322.1, NM_203388.2 NP_976323.1, NM_203389.2 XP_011518557.1, XM_011520255.1 XP_011518559.1, XM_011520257.2 XP_011518560.1, XM_011520258.2 XP_011518561.1, XM_011520259.2 XP_011518562.1, XM_011520260.2 XP_011518563.1, XM_011520261.2 XP_011518564.1, XM_011520262.2 XP_011518565.1, XM_011520263.1 XP_016873595.1, XM_017018106.1 |
3D structure databases
SMRi | A0A140VJT8 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A0A140VJT8, 1 interactor |
Protocols and materials databases
Antibodypediai | 22490, 457 antibodies from 31 providers |
DNASUi | 6050 |
Genome annotation databases
GeneIDi | 6050 |
KEGGi | hsa:6050 |
MANE-Selecti | ENST00000354420.7; ENSP00000346402.2; NM_203387.3; NP_976321.1 |
Organism-specific databases
CTDi | 6050 |
VEuPathDBi | HostDB:ENSG00000023191 |
Phylogenomic databases
OMAi | GGNDIHA |
OrthoDBi | 710473at2759 |
PhylomeDBi | A0A140VJT8 |
Miscellaneous databases
BioGRID-ORCSi | 6050, 64 hits in 1072 CRISPR screens |
GenomeRNAii | 6050 |
Gene expression databases
ExpressionAtlasi | A0A140VJT8, baseline and differential |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR006553, Leu-rich_rpt_Cys-con_subtyp IPR032675, LRR_dom_sf IPR041302, LRR_RI_cap |
Pfami | View protein in Pfam PF13516, LRR_6, 6 hits PF18779, LRR_RI_capping, 1 hit |
SMARTi | View protein in SMART SM00367, LRR_CC, 5 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A140VJT8_HUMAN | |
Accessioni | A0A140VJT8Primary (citable) accession number: A0A140VJT8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 8, 2016 |
Last sequence update: | June 8, 2016 | |
Last modified: | May 25, 2022 | |
This is version 30 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |