UniProtKB - A0A140VJS0 (A0A140VJS0_HUMAN)
Protein
Serine/threonine-protein phosphatase
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.1.3.16UniRule annotation
GO - Molecular functioni
- protein C-terminus binding Source: Ensembl
- protein serine phosphatase activity Source: UniProtKB-EC
- protein threonine phosphatase activity Source: UniProtKB-EC
GO - Biological processi
- apoptotic mitochondrial changes Source: Ensembl
- negative regulation of Ras protein signal transduction Source: Ensembl
- positive regulation of microtubule binding Source: Ensembl
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: Ensembl
- regulation of gene expression Source: Ensembl
- response to antibiotic Source: Ensembl
- response to endoplasmic reticulum stress Source: Ensembl
- response to hydrogen peroxide Source: Ensembl
- response to lead ion Source: Ensembl
Keywordsi
Molecular function | Hydrolase, Protein phosphataseARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein phosphataseUniRule annotation (EC:3.1.3.16UniRule annotation) |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Other locations
- cytoplasm Source: Ensembl
- protein phosphatase type 2A complex Source: Ensembl
Interactioni
GO - Molecular functioni
- protein C-terminus binding Source: Ensembl
Protein-protein interaction databases
IntActi | A0A140VJS0, 1 interactor |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 114 – 119 | SER_THR_PHOSPHATASEInterPro annotation | 6 |
Sequence similaritiesi
Belongs to the PPP phosphatase family.UniRule annotation
Phylogenomic databases
OMAi | EGYNWGQ |
OrthoDBi | 808922at2759 |
PhylomeDBi | A0A140VJS0 |
Family and domain databases
Gene3Di | 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like IPR006186, Ser/Thr-sp_prot-phosphatase |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit |
PRINTSi | PR00114, STPHPHTASE |
SMARTi | View protein in SMART SM00156, PP2Ac, 1 hit |
PROSITEi | View protein in PROSITE PS00125, SER_THR_PHOSPHATASE, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A140VJS0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDDKAFTKEL DQWVEQLNEC KQLNENQVRT LCEKAKEILT KESNVQEVRC
60 70 80 90 100
PVTVCGDVHG QFHDLMELFR IGGKSPDTNY LFMGDYVDRG YYSVETVTLL
110 120 130 140 150
VALKVRYPER ITILRGNHES RQITQVYGFY DECLRKYGNA NVWKYFTDLF
160 170 180 190 200
DYLPLTALVD GQIFCLHGGL SPSIDTLDHI RALDRLQEVP HEGPMCDLLW
210 220 230 240 250
SDPDDRGGWG ISPRGAGYTF GQDISETFNH ANGLTLVSRA HQLVMEGYNW
260 270 280 290 300
CHDRNVVTIF SAPNYCYRCG NQAAIMELDD TLKYSFLQFD PAPRRGEPHV
TRRTPDYFL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM005459 mRNA Translation: AEE61057.1 |
RefSeqi | NP_001009552.1, NM_001009552.1 |
Genome annotation databases
GeneIDi | 5516 |
KEGGi | hsa:5516 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM005459 mRNA Translation: AEE61057.1 |
RefSeqi | NP_001009552.1, NM_001009552.1 |
3D structure databases
SMRi | A0A140VJS0 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A0A140VJS0, 1 interactor |
Protocols and materials databases
Antibodypediai | 4349, 398 antibodies |
DNASUi | 5516 |
Genome annotation databases
GeneIDi | 5516 |
KEGGi | hsa:5516 |
Organism-specific databases
CTDi | 5516 |
Phylogenomic databases
OMAi | EGYNWGQ |
OrthoDBi | 808922at2759 |
PhylomeDBi | A0A140VJS0 |
Miscellaneous databases
BioGRID-ORCSi | 5516, 6 hits in 999 CRISPR screens |
GenomeRNAii | 5516 |
Gene expression databases
ExpressionAtlasi | A0A140VJS0, baseline and differential |
Family and domain databases
Gene3Di | 3.60.21.10, 1 hit |
InterProi | View protein in InterPro IPR004843, Calcineurin-like_PHP_ApaH IPR029052, Metallo-depent_PP-like IPR006186, Ser/Thr-sp_prot-phosphatase |
Pfami | View protein in Pfam PF00149, Metallophos, 1 hit |
PRINTSi | PR00114, STPHPHTASE |
SMARTi | View protein in SMART SM00156, PP2Ac, 1 hit |
PROSITEi | View protein in PROSITE PS00125, SER_THR_PHOSPHATASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A140VJS0_HUMAN | |
Accessioni | A0A140VJS0Primary (citable) accession number: A0A140VJS0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 8, 2016 |
Last sequence update: | June 8, 2016 | |
Last modified: | April 7, 2021 | |
This is version 25 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |