Testicular tissue protein Li 2

Functionⁱ

GO - Molecular functionⁱ

DNA binding Source: Ensembl
growth factor receptor binding Source: Ensembl
heparin binding Source: InterPro
peptidase activator activity Source: Ensembl
serine-type endopeptidase inhibitor activity Source: InterPro
signaling receptor activator activity Source: Ensembl
transition metal ion binding Source: InterPro

GO - Biological processⁱ

adult locomotory behavior Source: Ensembl
axo-dendritic transport Source: Ensembl
axon midline choice point recognition Source: Ensembl
cellular copper ion homeostasis Source: Ensembl
cellular response to cAMP Source: Ensembl
cellular response to copper ion Source: Ensembl
cellular response to manganese ion Source: Ensembl
cellular response to nerve growth factor stimulus Source: Ensembl
cellular response to norepinephrine stimulus Source: Ensembl
cholesterol metabolic process Source: Ensembl
collateral sprouting in absence of injury Source: Ensembl
dendrite development Source: Ensembl
endocytosis Source: Ensembl
extracellular matrix organization Source: Ensembl
forebrain development Source: Ensembl
ionotropic glutamate receptor signaling pathway Source: Ensembl
mating behavior Source: Ensembl
mRNA polyadenylation Source: Ensembl
negative regulation of neuron differentiation Source: Ensembl
neuromuscular process controlling balance Source: Ensembl
neuron apoptotic process Source: Ensembl
neuron remodeling Source: Ensembl
positive regulation of G2/M transition of mitotic cell cycle Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
protein phosphorylation Source: Ensembl
regulation of epidermal growth factor-activated receptor activity Source: Ensembl
regulation of multicellular organism growth Source: Ensembl
regulation of protein binding Source: Ensembl
regulation of synapse structure or activity Source: Ensembl
regulation of translation Source: Ensembl
response to interleukin-1 Source: Ensembl
response to lead ion Source: Ensembl
response to oxidative stress Source: Ensembl
smooth endoplasmic reticulum calcium ion homeostasis Source: Ensembl
suckling behavior Source: Ensembl
synaptic growth at neuromuscular junction Source: Ensembl
visual learning Source: Ensembl

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Testicular tissue protein Li 2Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

GO - Cellular component

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	701 – 723	HelicalSequence analysisAdd BLAST		23

Keywords - Cellular componentⁱ

Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	Sequence analysisAdd BLAST		17
ChainⁱPRO_5007491718	18 – 770	Sequence analysisAdd BLAST		753

Proteomic databases

PRIDEⁱ	A0A140VJC8

PRIDEⁱ

A0A140VJC8

Expressionⁱ

Gene expression databases

ExpressionAtlasⁱ	A0A140VJC8 baseline and differential

ExpressionAtlasⁱ

A0A140VJC8 baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

growth factor receptor binding Source: Ensembl

Complete GO annotation on QuickGO ...

Structureⁱ

3D structure databases

SMRⁱ	A0A140VJC8
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	291 – 341	BPTI/Kunitz inhibitorInterPro annotationAdd BLAST		51

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	194 – 284	DisorderedSequence analysisAdd BLAST		91

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	399 – 419	Sequence analysisAdd BLAST	21
Coiled coilⁱ	425 – 459	Sequence analysisAdd BLAST	35
Coiled coilⁱ	555 – 575	Sequence analysisAdd BLAST	21

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	195 – 210	AcidicSequence analysisAdd BLAST	16
Compositional biasⁱ	225 – 263	AcidicSequence analysisAdd BLAST	39
Compositional biasⁱ	267 – 284	PolarSequence analysisAdd BLAST	18

Keywords - Domainⁱ

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

KEGG Orthology (KO) More...KOⁱ	K04520
OMAⁱ	EGRCVQF
Database of Orthologous Groups More...OrthoDBⁱ	953529at2759
PhylomeDBⁱ	A0A140VJC8

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00109 KU, 1 hit
Gene3Dⁱ	1.20.120.770, 1 hit 2.30.29.30, 1 hit 3.30.1490.140, 1 hit 3.90.570.10, 1 hit 4.10.230.10, 1 hit 4.10.410.10, 1 hit
InterProⁱ	View protein in InterPro IPR036669 Amyloid_Cu-bd_sf IPR008155 Amyloid_glyco IPR013803 Amyloid_glyco_Abeta IPR037071 Amyloid_glyco_Abeta_sf IPR011178 Amyloid_glyco_Cu-bd IPR024329 Amyloid_glyco_E2_domain IPR008154 Amyloid_glyco_extra IPR015849 Amyloid_glyco_heparin-bd IPR036454 Amyloid_glyco_heparin-bd_sf IPR019745 Amyloid_glyco_intracell_CS IPR028866 APP IPR019543 APP_amyloid_C IPR019744 APP_CUBD_CS IPR036176 E2_sf IPR002223 Kunitz_BPTI IPR036880 Kunitz_BPTI_sf IPR011993 PH-like_dom_sf IPR020901 Prtase_inh_Kunz-CS
PANTHERⁱ	PTHR23103 PTHR23103, 1 hit PTHR23103:SF7 PTHR23103:SF7, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10515 APP_amyloid, 1 hit PF12924 APP_Cu_bd, 1 hit PF12925 APP_E2, 1 hit PF02177 APP_N, 1 hit PF03494 Beta-APP, 1 hit PF00014 Kunitz_BPTI, 1 hit
PRINTSⁱ	PR00203 AMYLOIDA4 PR00759 BASICPTASE PR00204 BETAAMYLOID
SMARTⁱ	View protein in SMART SM00006 A4_EXTRA, 1 hit SM00131 KU, 1 hit
SUPFAMⁱ	SSF109843 SSF109843, 1 hit SSF56491 SSF56491, 1 hit SSF57362 SSF57362, 1 hit SSF89811 SSF89811, 1 hit
PROSITEⁱ	View protein in PROSITE PS00319 APP_CUBD, 1 hit PS00320 APP_INTRA, 1 hit PS00280 BPTI_KUNITZ_1, 1 hit PS50279 BPTI_KUNITZ_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A140VJC8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLPGLALLLL AAWTARALEV PTDGNAGLLA EPQIAMFCGR LNMHMNVQNG 
        60         70         80         90        100
KWDSDPSGTK TCIDTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR 
       110        120        130        140        150
GRKQCKTHPH FVIPYRCLVG EFVSDALLVP DKCKFLHQER MDVCETHLHW 
       160        170        180        190        200
HTVAKETCSE KSTNLHDYGM LLPCGIDKFR GVEFVCCPLA EESDNVDSAD 
       210        220        230        240        250
AEEDDSDVWW GGADTDYADG SEDKVVEVAE EEEVAEVEEE EADDDEDDED 
       260        270        280        290        300
GDEVEEEAEE PYEEATERTT SIATTTTTTT ESVEEVVREV CSEQAETGPC 
       310        320        330        340        350
RAMISRWYFD VTEGKCAPFF YGGCGGNRNN FDTEEYCMAV CGSAMSQSLL 
       360        370        380        390        400
KTTQEPLARD PVKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA 
       410        420        430        440        450
KHRERMSQVM REWEEAERQA KNLPKADKKA VIQHFQEKVE SLEQEAANER 
       460        470        480        490        500
QQLVETHMAR VEAMLNDRRR LALENYITAL QAVPPRPRHV FNMLKKYVRA 
       510        520        530        540        550
EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER MNQSLSLLYN 
       560        570        580        590        600
VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN DALMPSLTET 
       610        620        630        640        650
KTTVELLPVN GEFSLDDLQP WHSFGADSVP ANTENEVEPV DARPAADRGL 
       660        670        680        690        700
TTRPGSGLTN IKTEEISEVK MDAEFRHDSG YEVHHQKLVF FAEDVGSNKG 
       710        720        730        740        750
AIIGLMVGGV VIATVIVITL VMLKKKQYTS IHHGVVEVDA AVTPEERHLS 
       760        770
KMQQNGYENP TYKFFEQMQN

Length:770

Mass (Da):86,943

Last modified:June 8, 2016 - v1

Checksum:ⁱA12EE761403740F5

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	HM005315 mRNA Translation: AEE60915.1
NCBI Reference Sequences More...RefSeqⁱ	NP_000475.1, NM_000484.3

Genome annotation databases

GeneIDⁱ	351
KEGGⁱ	hsa:351

Protein	Similar proteins		Species	Score	Length	Source
A0A140VJC8	Amyloid-beta precursor protein	)	HUMAN		770	UniRef100_P05067
Beta amyloid protein (Fragment)		MACMU		19
UPI0000110448		HUMAN		58

Protein	Similar proteins		Species	Score	Length	Source
A0A140VJC8	Amyloid-beta precursor protein	)	HUMAN		770	UniRef90_P05067
Amyloid-beta A4 protein		PANTR		770
Amyloid-beta A4 protein		PIG		770
Amyloid-beta A4 protein	)	MOUSE		770
Amyloid-beta A4 protein		MACFA		770
+462

Protein	Similar proteins		Species	Score	Length	Source
A0A140VJC8	Amyloid-beta precursor protein	)	HUMAN		770	UniRef50_P05067
Amyloid-beta A4 protein	)	MOUSE		770
Amyloid-beta A4 protein		PANTR		770
Amyloid-beta A4 protein		MACFA		770
Amyloid-beta A4 protein (Fragment)		MACMU		76
+1303

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	HM005315 mRNA Translation: AEE60915.1
RefSeqⁱ	NP_000475.1, NM_000484.3

3D structure databases

SMRⁱ	A0A140VJC8
ModBaseⁱ	Search...

Proteomic databases

PRIDEⁱ	A0A140VJC8

PRIDEⁱ

A0A140VJC8

Genome annotation databases

GeneIDⁱ	351
KEGGⁱ	hsa:351

Organism-specific databases

CTDⁱ	351

CTDⁱ

351

Phylogenomic databases

KOⁱ	K04520
OMAⁱ	EGRCVQF
OrthoDBⁱ	953529at2759
PhylomeDBⁱ	A0A140VJC8

Miscellaneous databases

GenomeRNAiⁱ	351

GenomeRNAiⁱ

351

Gene expression databases

ExpressionAtlasⁱ	A0A140VJC8 baseline and differential

ExpressionAtlasⁱ

A0A140VJC8 baseline and differential

Family and domain databases

CDDⁱ	cd00109 KU, 1 hit
Gene3Dⁱ	1.20.120.770, 1 hit 2.30.29.30, 1 hit 3.30.1490.140, 1 hit 3.90.570.10, 1 hit 4.10.230.10, 1 hit 4.10.410.10, 1 hit
InterProⁱ	View protein in InterPro IPR036669 Amyloid_Cu-bd_sf IPR008155 Amyloid_glyco IPR013803 Amyloid_glyco_Abeta IPR037071 Amyloid_glyco_Abeta_sf IPR011178 Amyloid_glyco_Cu-bd IPR024329 Amyloid_glyco_E2_domain IPR008154 Amyloid_glyco_extra IPR015849 Amyloid_glyco_heparin-bd IPR036454 Amyloid_glyco_heparin-bd_sf IPR019745 Amyloid_glyco_intracell_CS IPR028866 APP IPR019543 APP_amyloid_C IPR019744 APP_CUBD_CS IPR036176 E2_sf IPR002223 Kunitz_BPTI IPR036880 Kunitz_BPTI_sf IPR011993 PH-like_dom_sf IPR020901 Prtase_inh_Kunz-CS
PANTHERⁱ	PTHR23103 PTHR23103, 1 hit PTHR23103:SF7 PTHR23103:SF7, 1 hit
Pfamⁱ	View protein in Pfam PF10515 APP_amyloid, 1 hit PF12924 APP_Cu_bd, 1 hit PF12925 APP_E2, 1 hit PF02177 APP_N, 1 hit PF03494 Beta-APP, 1 hit PF00014 Kunitz_BPTI, 1 hit
PRINTSⁱ	PR00203 AMYLOIDA4 PR00759 BASICPTASE PR00204 BETAAMYLOID
SMARTⁱ	View protein in SMART SM00006 A4_EXTRA, 1 hit SM00131 KU, 1 hit
SUPFAMⁱ	SSF109843 SSF109843, 1 hit SSF56491 SSF56491, 1 hit SSF57362 SSF57362, 1 hit SSF89811 SSF89811, 1 hit
PROSITEⁱ	View protein in PROSITE PS00319 APP_CUBD, 1 hit PS00320 APP_INTRA, 1 hit PS00280 BPTI_KUNITZ_1, 1 hit PS50279 BPTI_KUNITZ_2, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A140VJC8_HUMAN
Accessionⁱ	A0A140VJC8Primary (citable) accession number: A0A140VJC8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 8, 2016
	Last sequence update:	June 8, 2016
	Last modified:	November 13, 2019
	This is version 29 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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UniProtKB - A0A140VJC8 (A0A140VJC8_HUMAN)

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Endoplasmic reticulum

Endosome

Extracellular region or secreted

Golgi apparatus

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ