UniProtKB - A0A140VJC8 (A0A140VJC8_HUMAN)
Protein
ABPP
Gene
N/A
Organism
Homo sapiens (Human)
Status
Functioni
N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).ARBA annotation
The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.ARBA annotation
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- growth factor receptor binding Source: Ensembl
- heparin binding Source: UniProtKB-KW
- peptidase activator activity Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
- serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
- signaling receptor activator activity Source: Ensembl
- transition metal ion binding Source: InterPro
GO - Biological processi
- adult locomotory behavior Source: Ensembl
- axo-dendritic transport Source: Ensembl
- axon midline choice point recognition Source: Ensembl
- cellular copper ion homeostasis Source: Ensembl
- cellular response to cAMP Source: Ensembl
- cellular response to copper ion Source: Ensembl
- cellular response to manganese ion Source: Ensembl
- cellular response to nerve growth factor stimulus Source: Ensembl
- cellular response to norepinephrine stimulus Source: Ensembl
- cholesterol metabolic process Source: Ensembl
- collateral sprouting in absence of injury Source: Ensembl
- dendrite development Source: Ensembl
- endocytosis Source: UniProtKB-KW
- extracellular matrix organization Source: Ensembl
- forebrain development Source: Ensembl
- ionotropic glutamate receptor signaling pathway Source: Ensembl
- mating behavior Source: Ensembl
- mRNA polyadenylation Source: Ensembl
- negative regulation of neuron differentiation Source: Ensembl
- neuromuscular process controlling balance Source: Ensembl
- neuron apoptotic process Source: Ensembl
- neuron remodeling Source: Ensembl
- Notch signaling pathway Source: UniProtKB-KW
- positive regulation of G2/M transition of mitotic cell cycle Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- protein phosphorylation Source: Ensembl
- regulation of epidermal growth factor-activated receptor activity Source: Ensembl
- regulation of multicellular organism growth Source: Ensembl
- regulation of protein binding Source: Ensembl
- regulation of synapse structure or activity Source: Ensembl
- regulation of translation Source: Ensembl
- response to interleukin-1 Source: Ensembl
- response to lead ion Source: Ensembl
- response to oxidative stress Source: Ensembl
- smooth endoplasmic reticulum calcium ion homeostasis Source: Ensembl
- suckling behavior Source: Ensembl
- synaptic growth at neuromuscular junction Source: Ensembl
- visual learning Source: Ensembl
Keywordsi
Molecular function | Heparin-bindingARBA annotation, Protease inhibitor, Serine protease inhibitorARBA annotation |
Biological process | EndocytosisARBA annotation, Notch signaling pathwayARBA annotation |
Ligand | CopperARBA annotation, Metal-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: ABPPARBA annotationAlternative name(s): Alpha-secretase C-terminal fragmentARBA annotation Amyloid precursor proteinARBA annotation Amyloid-beta A4 proteinARBA annotation Amyloid-beta precursor proteinARBA annotation Amyloid-beta protein 40ARBA annotation Amyloid-beta protein 42ARBA annotation Beta-APP40ARBA annotation Beta-APP42ARBA annotation Beta-secretase C-terminal fragmentARBA annotation C31ARBA annotation C80ARBA annotation C83ARBA annotation C99ARBA annotation Gamma-CTF(50)ARBA annotation Gamma-CTF(57)ARBA annotation Gamma-CTF(59)ARBA annotation Gamma-secretase C-terminal fragment 50ARBA annotation Gamma-secretase C-terminal fragment 57ARBA annotation Gamma-secretase C-terminal fragment 59ARBA annotation N-APPARBA annotation P3(40)ARBA annotation P3(42)ARBA annotation Soluble APP-alphaARBA annotation Soluble APP-betaARBA annotation |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Endosome
- Early endosome ARBA annotation
- Endosome ARBA annotation
Plasma membrane
- Cell membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Other locations
- growth cone ARBA annotation
- Cell surface ARBA annotation
- Cytoplasmic vesicle ARBA annotation
- clathrin-coated pit ARBA annotation
- Membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
- Perikaryon ARBA annotation
- Vesicle ARBA annotation
Cytoskeleton
- ciliary rootlet Source: Ensembl
- spindle midzone Source: Ensembl
Endoplasmic reticulum
- rough endoplasmic reticulum Source: Ensembl
- smooth endoplasmic reticulum Source: GOC
Endosome
- early endosome Source: UniProtKB-SubCell
- recycling endosome Source: Ensembl
Extracellular region or secreted
- extracellular space Source: Ensembl
Golgi apparatus
- Golgi apparatus Source: Ensembl
Plasma Membrane
- clathrin-coated pit Source: UniProtKB-SubCell
Other locations
- apical part of cell Source: Ensembl
- astrocyte projection Source: Ensembl
- cell surface Source: UniProtKB-SubCell
- cell-cell junction Source: Ensembl
- COPII-coated ER to Golgi transport vesicle Source: Ensembl
- growth cone filopodium Source: Ensembl
- growth cone lamellipodium Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
- main axon Source: Ensembl
- membrane raft Source: Ensembl
- neuromuscular junction Source: Ensembl
- perikaryon Source: UniProtKB-SubCell
- perinuclear region of cytoplasm Source: Ensembl
- presynaptic active zone Source: Ensembl
- synaptic vesicle Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 701 – 723 | HelicalSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
Coated pitARBA annotation, Cytoplasmic vesicleARBA annotation, EndosomeARBA annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Sequence analysisAdd BLAST | 17 | |
ChainiPRO_5007491718 | 18 – 770 | ABPPSequence analysisAdd BLAST | 753 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 73 ↔ 117 | PROSITE-ProRule annotation | ||
Disulfide bondi | 98 ↔ 105 | PROSITE-ProRule annotation | ||
Disulfide bondi | 133 ↔ 187 | PROSITE-ProRule annotation | ||
Disulfide bondi | 144 ↔ 174 | PROSITE-ProRule annotation | ||
Disulfide bondi | 158 ↔ 186 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation, SulfationARBA annotationInteractioni
GO - Molecular functioni
- growth factor receptor binding Source: Ensembl
Chemistry databases
BindingDBi | A0A140VJC8 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 189 | E1InterPro annotationAdd BLAST | 162 | |
Domaini | 291 – 341 | BPTI/Kunitz inhibitorInterPro annotationAdd BLAST | 51 | |
Domaini | 374 – 565 | E2InterPro annotationAdd BLAST | 192 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 28 – 123 | GFLD subdomainPROSITE-ProRule annotationAdd BLAST | 96 | |
Regioni | 131 – 189 | CuBD subdomainPROSITE-ProRule annotationAdd BLAST | 59 | |
Regioni | 194 – 284 | DisorderedSequence analysisAdd BLAST | 91 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 399 – 419 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 425 – 459 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 555 – 575 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 195 – 210 | AcidicSequence analysisAdd BLAST | 16 | |
Compositional biasi | 225 – 263 | AcidicSequence analysisAdd BLAST | 39 | |
Compositional biasi | 267 – 284 | PolarSequence analysisAdd BLAST | 18 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysis, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisARBA annotationPhylogenomic databases
OMAi | WSELEDR |
OrthoDBi | 953529at2759 |
PhylomeDBi | A0A140VJC8 |
Family and domain databases
CDDi | cd00109, KU, 1 hit |
Gene3Di | 1.20.120.770, 1 hit 2.30.29.30, 1 hit 3.30.1490.140, 1 hit 3.90.570.10, 1 hit 4.10.230.10, 1 hit 4.10.410.10, 1 hit |
InterProi | View protein in InterPro IPR036669, Amyloid_Cu-bd_sf IPR008155, Amyloid_glyco IPR013803, Amyloid_glyco_Abeta IPR037071, Amyloid_glyco_Abeta_sf IPR011178, Amyloid_glyco_Cu-bd IPR024329, Amyloid_glyco_E2_domain IPR008154, Amyloid_glyco_extra IPR015849, Amyloid_glyco_heparin-bd IPR036454, Amyloid_glyco_heparin-bd_sf IPR019745, Amyloid_glyco_intracell_CS IPR028866, APP IPR019543, APP_amyloid_C IPR019744, APP_CUBD_CS IPR036176, E2_sf IPR002223, Kunitz_BPTI IPR036880, Kunitz_BPTI_sf IPR011993, PH-like_dom_sf IPR020901, Prtase_inh_Kunz-CS |
PANTHERi | PTHR23103, PTHR23103, 1 hit PTHR23103:SF7, PTHR23103:SF7, 1 hit |
Pfami | View protein in Pfam PF10515, APP_amyloid, 1 hit PF12924, APP_Cu_bd, 1 hit PF12925, APP_E2, 1 hit PF02177, APP_N, 1 hit PF03494, Beta-APP, 1 hit PF00014, Kunitz_BPTI, 1 hit |
PRINTSi | PR00203, AMYLOIDA4 PR00759, BASICPTASE PR00204, BETAAMYLOID |
SMARTi | View protein in SMART SM00006, A4_EXTRA, 1 hit SM00131, KU, 1 hit |
SUPFAMi | SSF109843, SSF109843, 1 hit SSF56491, SSF56491, 1 hit SSF57362, SSF57362, 1 hit SSF89811, SSF89811, 1 hit |
PROSITEi | View protein in PROSITE PS00319, APP_CUBD, 1 hit PS51869, APP_E1, 1 hit PS51870, APP_E2, 1 hit PS00320, APP_INTRA, 1 hit PS00280, BPTI_KUNITZ_1, 1 hit PS50279, BPTI_KUNITZ_2, 1 hit |
i Sequence
Sequence statusi: Complete.
A0A140VJC8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPGLALLLL AAWTARALEV PTDGNAGLLA EPQIAMFCGR LNMHMNVQNG
60 70 80 90 100
KWDSDPSGTK TCIDTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR
110 120 130 140 150
GRKQCKTHPH FVIPYRCLVG EFVSDALLVP DKCKFLHQER MDVCETHLHW
160 170 180 190 200
HTVAKETCSE KSTNLHDYGM LLPCGIDKFR GVEFVCCPLA EESDNVDSAD
210 220 230 240 250
AEEDDSDVWW GGADTDYADG SEDKVVEVAE EEEVAEVEEE EADDDEDDED
260 270 280 290 300
GDEVEEEAEE PYEEATERTT SIATTTTTTT ESVEEVVREV CSEQAETGPC
310 320 330 340 350
RAMISRWYFD VTEGKCAPFF YGGCGGNRNN FDTEEYCMAV CGSAMSQSLL
360 370 380 390 400
KTTQEPLARD PVKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA
410 420 430 440 450
KHRERMSQVM REWEEAERQA KNLPKADKKA VIQHFQEKVE SLEQEAANER
460 470 480 490 500
QQLVETHMAR VEAMLNDRRR LALENYITAL QAVPPRPRHV FNMLKKYVRA
510 520 530 540 550
EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER MNQSLSLLYN
560 570 580 590 600
VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN DALMPSLTET
610 620 630 640 650
KTTVELLPVN GEFSLDDLQP WHSFGADSVP ANTENEVEPV DARPAADRGL
660 670 680 690 700
TTRPGSGLTN IKTEEISEVK MDAEFRHDSG YEVHHQKLVF FAEDVGSNKG
710 720 730 740 750
AIIGLMVGGV VIATVIVITL VMLKKKQYTS IHHGVVEVDA AVTPEERHLS
760 770
KMQQNGYENP TYKFFEQMQN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM005315 mRNA Translation: AEE60915.1 |
RefSeqi | NP_000475.1, NM_000484.3 |
Genome annotation databases
GeneIDi | 351 |
KEGGi | hsa:351 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | HM005315 mRNA Translation: AEE60915.1 |
RefSeqi | NP_000475.1, NM_000484.3 |
3D structure databases
SMRi | A0A140VJC8 |
ModBasei | Search... |
Chemistry databases
BindingDBi | A0A140VJC8 |
Protocols and materials databases
Antibodypediai | 668, 4008 antibodies |
Genome annotation databases
GeneIDi | 351 |
KEGGi | hsa:351 |
Organism-specific databases
CTDi | 351 |
Phylogenomic databases
OMAi | WSELEDR |
OrthoDBi | 953529at2759 |
PhylomeDBi | A0A140VJC8 |
Miscellaneous databases
BioGRID-ORCSi | 351, 6 hits in 882 CRISPR screens |
GenomeRNAii | 351 |
Gene expression databases
ExpressionAtlasi | A0A140VJC8, baseline and differential |
Family and domain databases
CDDi | cd00109, KU, 1 hit |
Gene3Di | 1.20.120.770, 1 hit 2.30.29.30, 1 hit 3.30.1490.140, 1 hit 3.90.570.10, 1 hit 4.10.230.10, 1 hit 4.10.410.10, 1 hit |
InterProi | View protein in InterPro IPR036669, Amyloid_Cu-bd_sf IPR008155, Amyloid_glyco IPR013803, Amyloid_glyco_Abeta IPR037071, Amyloid_glyco_Abeta_sf IPR011178, Amyloid_glyco_Cu-bd IPR024329, Amyloid_glyco_E2_domain IPR008154, Amyloid_glyco_extra IPR015849, Amyloid_glyco_heparin-bd IPR036454, Amyloid_glyco_heparin-bd_sf IPR019745, Amyloid_glyco_intracell_CS IPR028866, APP IPR019543, APP_amyloid_C IPR019744, APP_CUBD_CS IPR036176, E2_sf IPR002223, Kunitz_BPTI IPR036880, Kunitz_BPTI_sf IPR011993, PH-like_dom_sf IPR020901, Prtase_inh_Kunz-CS |
PANTHERi | PTHR23103, PTHR23103, 1 hit PTHR23103:SF7, PTHR23103:SF7, 1 hit |
Pfami | View protein in Pfam PF10515, APP_amyloid, 1 hit PF12924, APP_Cu_bd, 1 hit PF12925, APP_E2, 1 hit PF02177, APP_N, 1 hit PF03494, Beta-APP, 1 hit PF00014, Kunitz_BPTI, 1 hit |
PRINTSi | PR00203, AMYLOIDA4 PR00759, BASICPTASE PR00204, BETAAMYLOID |
SMARTi | View protein in SMART SM00006, A4_EXTRA, 1 hit SM00131, KU, 1 hit |
SUPFAMi | SSF109843, SSF109843, 1 hit SSF56491, SSF56491, 1 hit SSF57362, SSF57362, 1 hit SSF89811, SSF89811, 1 hit |
PROSITEi | View protein in PROSITE PS00319, APP_CUBD, 1 hit PS51869, APP_E1, 1 hit PS51870, APP_E2, 1 hit PS00320, APP_INTRA, 1 hit PS00280, BPTI_KUNITZ_1, 1 hit PS50279, BPTI_KUNITZ_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A140VJC8_HUMAN | |
Accessioni | A0A140VJC8Primary (citable) accession number: A0A140VJC8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 8, 2016 |
Last sequence update: | June 8, 2016 | |
Last modified: | February 10, 2021 | |
This is version 36 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |