Amyloid-beta A4 protein

Functionⁱ

Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis.

UniRule annotation

N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).

ARBA annotation

The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.

ARBA annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functionⁱ

growth factor receptor binding Source: Ensembl
heparin binding Source: UniProtKB-UniRule
peptidase activator activity Source: Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
serine-type endopeptidase inhibitor activity Source: UniProtKB-KW
signaling receptor activator activity Source: Ensembl
transition metal ion binding Source: InterPro

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

adult locomotory behavior Source: Ensembl
axo-dendritic transport Source: Ensembl
axon midline choice point recognition Source: Ensembl
cellular copper ion homeostasis Source: Ensembl
cellular response to cAMP Source: Ensembl
cellular response to copper ion Source: Ensembl
cellular response to manganese ion Source: Ensembl
cellular response to nerve growth factor stimulus Source: Ensembl
cellular response to norepinephrine stimulus Source: Ensembl
cholesterol metabolic process Source: Ensembl
collateral sprouting in absence of injury Source: Ensembl
dendrite development Source: Ensembl
endocytosis Source: UniProtKB-KW
extracellular matrix organization Source: Ensembl
forebrain development Source: Ensembl
ionotropic glutamate receptor signaling pathway Source: Ensembl
mating behavior Source: Ensembl
mRNA polyadenylation Source: Ensembl
negative regulation of neuron differentiation Source: Ensembl
neuromuscular process controlling balance Source: Ensembl
neuron apoptotic process Source: Ensembl
neuron remodeling Source: Ensembl
Notch signaling pathway Source: UniProtKB-KW
positive regulation of G2/M transition of mitotic cell cycle Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
protein phosphorylation Source: Ensembl
regulation of epidermal growth factor-activated receptor activity Source: Ensembl
regulation of multicellular organism growth Source: Ensembl
regulation of protein binding Source: Ensembl
regulation of synapse structure or activity Source: Ensembl
regulation of translation Source: Ensembl
response to interleukin-1 Source: Ensembl
response to lead ion Source: Ensembl
response to oxidative stress Source: Ensembl
smooth endoplasmic reticulum calcium ion homeostasis Source: Ensembl
suckling behavior Source: Ensembl
synaptic growth at neuromuscular junction Source: Ensembl
visual learning Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Heparin-bindingARBA annotation, Protease inhibitor, Serine protease inhibitorARBA annotation
Biological process	EndocytosisARBA annotation, Notch signaling pathwayARBA annotation
Ligand	CopperARBA annotation, Metal-bindingARBA annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Amyloid-beta A4 proteinUniRule annotation
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	701 – 723	HelicalUniRule annotationAdd BLAST		23

Keywords - Cellular componentⁱ

AmyloidUniRule annotation, Cell membraneUniRule annotation, Coated pitARBA annotation, Cytoplasmic vesicleARBA annotation, EndosomeARBA annotation, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	Sequence analysisAdd BLAST		17
ChainⁱPRO_5007491718	18 – 770	Amyloid-beta A4 proteinSequence analysisAdd BLAST		753

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	73 ↔ 117	PROSITE-ProRule annotation
Disulfide bondⁱ	98 ↔ 105	PROSITE-ProRule annotation
Disulfide bondⁱ	133 ↔ 187	PROSITE-ProRule annotation
Disulfide bondⁱ	144 ↔ 174	PROSITE-ProRule annotation
Disulfide bondⁱ	158 ↔ 186	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation, SulfationARBA annotation

Expressionⁱ

Gene expression databases

ExpressionAtlasⁱ	A0A140VJC8, baseline and differential

ExpressionAtlasⁱ

A0A140VJC8, baseline and differential

Interactionⁱ

GO - Molecular functionⁱ

growth factor receptor binding Source: Ensembl

Complete GO annotation on QuickGO ...

Chemistry databases

BindingDBⁱ	A0A140VJC8

BindingDBⁱ

A0A140VJC8

Structureⁱ

3D structure databases

SMRⁱ	A0A140VJC8
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	28 – 189	E1InterPro annotationAdd BLAST	162
Domainⁱ	291 – 341	BPTI/Kunitz inhibitorInterPro annotationAdd BLAST	51
Domainⁱ	374 – 565	E2InterPro annotationAdd BLAST	192

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	28 – 123	GFLD subdomainPROSITE-ProRule annotationAdd BLAST	96
Regionⁱ	131 – 189	CuBD subdomainPROSITE-ProRule annotationAdd BLAST	59
Regionⁱ	194 – 284	DisorderedSequence analysisAdd BLAST	91

Coiled coil

Feature key	Position(s)	DescriptionActions	Length
Coiled coilⁱ	399 – 419	Sequence analysisAdd BLAST	21
Coiled coilⁱ	425 – 459	Sequence analysisAdd BLAST	35
Coiled coilⁱ	555 – 575	Sequence analysisAdd BLAST	21

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	195 – 210	Acidic residuesSequence analysisAdd BLAST	16
Compositional biasⁱ	225 – 263	Acidic residuesSequence analysisAdd BLAST	39
Compositional biasⁱ	267 – 284	Polar residuesSequence analysisAdd BLAST	18

Sequence similaritiesⁱ

Belongs to the APP family.PROSITE-ProRule annotationARBA annotation

Keywords - Domainⁱ

Coiled coilSequence analysis, SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

OMAⁱ	WSELEDR
Database of Orthologous Groups More...OrthoDBⁱ	953529at2759
PhylomeDBⁱ	A0A140VJC8

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00109, KU, 1 hit
Gene3Dⁱ	1.20.120.770, 1 hit 2.30.29.30, 1 hit 3.30.1490.140, 1 hit 3.90.570.10, 1 hit 4.10.230.10, 1 hit 4.10.410.10, 1 hit
InterProⁱ	View protein in InterPro IPR036669, Amyloid_Cu-bd_sf IPR008155, Amyloid_glyco IPR013803, Amyloid_glyco_Abeta IPR037071, Amyloid_glyco_Abeta_sf IPR011178, Amyloid_glyco_Cu-bd IPR024329, Amyloid_glyco_E2_domain IPR008154, Amyloid_glyco_extra IPR015849, Amyloid_glyco_heparin-bd IPR036454, Amyloid_glyco_heparin-bd_sf IPR019745, Amyloid_glyco_intracell_CS IPR028866, APP IPR019543, APP_amyloid_C IPR019744, APP_CUBD_CS IPR036176, E2_sf IPR002223, Kunitz_BPTI IPR036880, Kunitz_BPTI_sf IPR011993, PH-like_dom_sf IPR020901, Prtase_inh_Kunz-CS
PANTHERⁱ	PTHR23103, PTHR23103, 1 hit PTHR23103:SF7, PTHR23103:SF7, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10515, APP_amyloid, 1 hit PF12924, APP_Cu_bd, 1 hit PF12925, APP_E2, 1 hit PF02177, APP_N, 1 hit PF03494, Beta-APP, 1 hit PF00014, Kunitz_BPTI, 1 hit
PRINTSⁱ	PR00203, AMYLOIDA4 PR00759, BASICPTASE PR00204, BETAAMYLOID
SMARTⁱ	View protein in SMART SM00006, A4_EXTRA, 1 hit SM00131, KU, 1 hit
SUPFAMⁱ	SSF109843, SSF109843, 1 hit SSF56491, SSF56491, 1 hit SSF57362, SSF57362, 1 hit SSF89811, SSF89811, 1 hit
PROSITEⁱ	View protein in PROSITE PS00319, APP_CUBD, 1 hit PS51869, APP_E1, 1 hit PS51870, APP_E2, 1 hit PS00320, APP_INTRA, 1 hit PS00280, BPTI_KUNITZ_1, 1 hit PS50279, BPTI_KUNITZ_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

A0A140VJC8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLPGLALLLL AAWTARALEV PTDGNAGLLA EPQIAMFCGR LNMHMNVQNG 
        60         70         80         90        100
KWDSDPSGTK TCIDTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR 
       110        120        130        140        150
GRKQCKTHPH FVIPYRCLVG EFVSDALLVP DKCKFLHQER MDVCETHLHW 
       160        170        180        190        200
HTVAKETCSE KSTNLHDYGM LLPCGIDKFR GVEFVCCPLA EESDNVDSAD 
       210        220        230        240        250
AEEDDSDVWW GGADTDYADG SEDKVVEVAE EEEVAEVEEE EADDDEDDED 
       260        270        280        290        300
GDEVEEEAEE PYEEATERTT SIATTTTTTT ESVEEVVREV CSEQAETGPC 
       310        320        330        340        350
RAMISRWYFD VTEGKCAPFF YGGCGGNRNN FDTEEYCMAV CGSAMSQSLL 
       360        370        380        390        400
KTTQEPLARD PVKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA 
       410        420        430        440        450
KHRERMSQVM REWEEAERQA KNLPKADKKA VIQHFQEKVE SLEQEAANER 
       460        470        480        490        500
QQLVETHMAR VEAMLNDRRR LALENYITAL QAVPPRPRHV FNMLKKYVRA 
       510        520        530        540        550
EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER MNQSLSLLYN 
       560        570        580        590        600
VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN DALMPSLTET 
       610        620        630        640        650
KTTVELLPVN GEFSLDDLQP WHSFGADSVP ANTENEVEPV DARPAADRGL 
       660        670        680        690        700
TTRPGSGLTN IKTEEISEVK MDAEFRHDSG YEVHHQKLVF FAEDVGSNKG 
       710        720        730        740        750
AIIGLMVGGV VIATVIVITL VMLKKKQYTS IHHGVVEVDA AVTPEERHLS 
       760        770
KMQQNGYENP TYKFFEQMQN

Length:770

Mass (Da):86,943

Last modified:June 8, 2016 - v1

Checksum:ⁱA12EE761403740F5

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	HM005315 mRNA Translation: AEE60915.1
NCBI Reference Sequences More...RefSeqⁱ	NP_000475.1, NM_000484.3

Genome annotation databases

GeneIDⁱ	351
KEGGⁱ	hsa:351

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
A0A140VJC8	Amyloid-beta precursor protein	)	HUMAN		770	UniRef100_P05067
Beta amyloid protein (Fragment)		MACMU		19
+1

Protein	Similar proteins		Species	Score	Length	Source
A0A140VJC8	Amyloid-beta precursor protein	)	HUMAN		770	UniRef90_P05067
Amyloid-beta A4 protein		PIG		770
Amyloid-beta A4 protein		PANTR		770
Amyloid-beta A4 protein		CAVPO		770
Amyloid-beta A4 protein	)	RAT		770
+458

Protein	Similar proteins		Species	Score	Length	Source
A0A140VJC8	Amyloid-beta precursor protein	)	HUMAN		770	UniRef50_P05067
Amyloid-beta A4 protein	)	MOUSE		770
Amyloid-beta A4 protein		PANTR		770
Amyloid-beta A4 protein	)	RAT		770
Amyloid-beta A4 protein		CAVPO		770
+1532

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	HM005315 mRNA Translation: AEE60915.1
RefSeqⁱ	NP_000475.1, NM_000484.3

3D structure databases

SMRⁱ	A0A140VJC8
ModBaseⁱ	Search...

Chemistry databases

BindingDBⁱ	A0A140VJC8

BindingDBⁱ

A0A140VJC8

Protocols and materials databases

Antibodypediaⁱ	668, 4300 antibodies
The DNASU plasmid repository More...DNASUⁱ	351

Genome annotation databases

GeneIDⁱ	351
KEGGⁱ	hsa:351

Organism-specific databases

CTDⁱ	351

CTDⁱ

351

Phylogenomic databases

OMAⁱ	WSELEDR
OrthoDBⁱ	953529at2759
PhylomeDBⁱ	A0A140VJC8

Miscellaneous databases

BioGRID-ORCSⁱ	351, 7 hits in 995 CRISPR screens
GenomeRNAiⁱ	351

Gene expression databases

ExpressionAtlasⁱ	A0A140VJC8, baseline and differential

ExpressionAtlasⁱ

A0A140VJC8, baseline and differential

Family and domain databases

CDDⁱ	cd00109, KU, 1 hit
Gene3Dⁱ	1.20.120.770, 1 hit 2.30.29.30, 1 hit 3.30.1490.140, 1 hit 3.90.570.10, 1 hit 4.10.230.10, 1 hit 4.10.410.10, 1 hit
InterProⁱ	View protein in InterPro IPR036669, Amyloid_Cu-bd_sf IPR008155, Amyloid_glyco IPR013803, Amyloid_glyco_Abeta IPR037071, Amyloid_glyco_Abeta_sf IPR011178, Amyloid_glyco_Cu-bd IPR024329, Amyloid_glyco_E2_domain IPR008154, Amyloid_glyco_extra IPR015849, Amyloid_glyco_heparin-bd IPR036454, Amyloid_glyco_heparin-bd_sf IPR019745, Amyloid_glyco_intracell_CS IPR028866, APP IPR019543, APP_amyloid_C IPR019744, APP_CUBD_CS IPR036176, E2_sf IPR002223, Kunitz_BPTI IPR036880, Kunitz_BPTI_sf IPR011993, PH-like_dom_sf IPR020901, Prtase_inh_Kunz-CS
PANTHERⁱ	PTHR23103, PTHR23103, 1 hit PTHR23103:SF7, PTHR23103:SF7, 1 hit
Pfamⁱ	View protein in Pfam PF10515, APP_amyloid, 1 hit PF12924, APP_Cu_bd, 1 hit PF12925, APP_E2, 1 hit PF02177, APP_N, 1 hit PF03494, Beta-APP, 1 hit PF00014, Kunitz_BPTI, 1 hit
PRINTSⁱ	PR00203, AMYLOIDA4 PR00759, BASICPTASE PR00204, BETAAMYLOID
SMARTⁱ	View protein in SMART SM00006, A4_EXTRA, 1 hit SM00131, KU, 1 hit
SUPFAMⁱ	SSF109843, SSF109843, 1 hit SSF56491, SSF56491, 1 hit SSF57362, SSF57362, 1 hit SSF89811, SSF89811, 1 hit
PROSITEⁱ	View protein in PROSITE PS00319, APP_CUBD, 1 hit PS51869, APP_E1, 1 hit PS51870, APP_E2, 1 hit PS00320, APP_INTRA, 1 hit PS00280, BPTI_KUNITZ_1, 1 hit PS50279, BPTI_KUNITZ_2, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	A0A140VJC8_HUMAN
Accessionⁱ	A0A140VJC8Primary (citable) accession number: A0A140VJC8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 8, 2016
	Last sequence update:	June 8, 2016
	Last modified:	June 2, 2021
	This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - A0A140VJC8 (A0A140VJC8_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endosome

Other locations

Cytoskeleton

Endoplasmic reticulum

Endosome

Extracellular region or secreted

Golgi apparatus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Chemistry databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ