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Entry version 25 (03 Jul 2019)
Sequence version 1 (11 May 2016)
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Protein

Condensin-2 complex subunit D3

Gene

Ncapd3

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, DNA condensationUniRule annotation, MitosisUniRule annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-2299718 Condensation of Prophase Chromosomes

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Condensin-2 complex subunit D3UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ncapd3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Rat genome database

More...
RGDi
1562176 Ncapd3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0A140UHX3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the condensin-2 complex.

UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000012078

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini953 – 1129Cnd1InterPro annotationAdd BLAST177

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni157 – 198DisorderedSequence analysisAdd BLAST42
Regioni1308 – 1331DisorderedSequence analysisAdd BLAST24
Regioni1374 – 1401DisorderedSequence analysisAdd BLAST28
Regioni1459 – 1497DisorderedSequence analysisAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1245 – 1265Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi165 – 183BasicSequence analysisAdd BLAST19
Compositional biasi1374 – 1397PolarSequence analysisAdd BLAST24
Compositional biasi1463 – 1481PolarSequence analysisAdd BLAST19

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153566

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111840

Identification of Orthologs from Complete Genome Data

More...
OMAi
NNVVIVM

Database of Orthologous Groups

More...
OrthoDBi
60751at2759

TreeFam database of animal gene trees

More...
TreeFami
TF101162

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR026971 CND1/NCAPD3
IPR032682 Cnd1_C
IPR012371 NCAPD3

The PANTHER Classification System

More...
PANTHERi
PTHR14222 PTHR14222, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12717 Cnd1, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF036508 Condns_HCP-6, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A140UHX3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGMALKDLG RDLQPWCPLD LSLEWVNTVW DLDFTETEPL DPSVVAEILE
60 70 80 90 100
TGRDAFTKLY GSLFPFATDE SGSLESVWSF FTENSISSNT LVALFCHFVQ
110 120 130 140 150
EAHKKSASVQ YREYGLRAAG LYFLLLEIPG SVVNQVFHPV MFDKCIQILK
160 170 180 190 200
KSWPQESNLT QKRKKEHSKS SKANYRRSRK RGKPPRKEDY QVDELSREEE
210 220 230 240 250
EEEEEEIYFS VRDLSQIRDA IFNLLKNFLR LLPKFSLKEK PQSIQTCIEV
260 270 280 290 300
FVALTSFEPI PHKFLISQAR NLSEVKHISE LAYYGLYLLC SPVHGEGNKV
310 320 330 340 350
IGSIFHQMLN VILMLEVGEG SRCAPLAITS HVINCRNQAV QFVSSLVDEL
360 370 380 390 400
QESVFPILGT LLQHICAKVV DKAEYRTYAA QSLVQLLSKL PSKEYATFIA
410 420 430 440 450
WLYKYSRSSK IPHRVFTLDV ALALLELPER LLDDTVLLEH QKFLKHKFFV
460 470 480 490 500
QEIIFDRCLD KAPTVRSKAL SSFAQCLELS TSNTSENTLE IFINSTVTGI
510 520 530 540 550
HSHFGTSLRP STVLTSQSCR SVQSSTHDSD EQTPPGERRF MTMLRKRTKD
560 570 580 590 600
EKINVRKSAL QVLMSILKHC DILSMEEDLL ILQDHCRDPA ISVRKQALQS
610 620 630 640 650
LTELVMAKPT CVPVQKAWLM GVIPVVMDYE STVQEKALEC LDQLLLQNIK
660 670 680 690 700
HHRKFHSEDR SQVLAWALLA LLTVESQDLS RYLNKAFHIW SKKDKFSSTF
710 720 730 740 750
INSVISHTDT ERSAPAWMLL SKITCSSPKL DYTKIMESWE KLSREQSPNS
760 770 780 790 800
NTLGYMLCVI GHIAKHLPKS TQDKITGVIK AKLNGFQWSL ELISLSVDTL
810 820 830 840 850
QGLCRASAKT LREEQELLKR VCGDVLSTCE QHLSNILLKE DGTGNMDEDL
860 870 880 890 900
VVKCIFTLGD IAQLCPALVE KRVFLLIQSI LASSAHADHL PSSQGTTDLA
910 920 930 940 950
SQLPFQARSS ALPSVIRAHA IITLGKLCLQ HEDLAKKSIP ALVRELEVCE
960 970 980 990 1000
DVAVRNNVII VMCDLCIRYT VMVDNYIPNI SICLKDSDPF IRKQTLILLT
1010 1020 1030 1040 1050
NLLQEEYVKW KGSLFFRFVS TLVDSHPDIA SLGEFCLAHL LLKRNPTMFF
1060 1070 1080 1090 1100
QHFIECIFHF NSYEKHGQYN KFSQSERGKP LFLLKGKTNK EKRMRIYKFL
1110 1120 1130 1140 1150
LEHFTDEQRF NVTSKICLNI LACFTDGVLP VDMEASELLS DTFDILSSKE
1160 1170 1180 1190 1200
IKLLAMRAQA SKELLEEDDV ALANVVMQEA QMKIISQVQK RNFIENIIPI
1210 1220 1230 1240 1250
IISLKTVLEK NKIPALRELM NYLREVMQDY RDEIKDFFAV DRQLASELEY
1260 1270 1280 1290 1300
DMKKYTEQLA QEQALTEHAN ATNVPADGDR VPSQQVAPDL QAVPGAAAAA
1310 1320 1330 1340 1350
GAGQADANMP LPLAQSQPSA PGSSFTPTLP PICEKGPLKI MSSTRPMSLS
1360 1370 1380 1390 1400
TIAILNSVKK AVASKSRTRS LGALSFNMEN GSPENPSSRA SSLSLEQESE
1410 1420 1430 1440 1450
RAVKRVTKRA ISTPEKSISN VTFGAGVSYI GTPATSFFTK EKPEEAQEEG
1460 1470 1480 1490
NDILCLSLLD KRPPQSPQWN VKSPARSQDN PRSGRRSLRK APLKTAN
Length:1,497
Mass (Da):168,778
Last modified:May 11, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAFC5F51798F546BD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AABR07069536 Genomic DNA No translation available.
AABR07069537 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_006242797.1, XM_006242735.3
XP_006242798.1, XM_006242736.3
XP_008764275.1, XM_008766053.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000012078; ENSRNOP00000012078; ENSRNOG00000008932

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
315508

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07069536 Genomic DNA No translation available.
AABR07069537 Genomic DNA No translation available.
RefSeqiXP_006242797.1, XM_006242735.3
XP_006242798.1, XM_006242736.3
XP_008764275.1, XM_008766053.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012078

Proteomic databases

PaxDbiA0A140UHX3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012078; ENSRNOP00000012078; ENSRNOG00000008932
GeneIDi315508

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23310
RGDi1562176 Ncapd3

Phylogenomic databases

GeneTreeiENSGT00940000153566
HOGENOMiHOG000111840
OMAiNNVVIVM
OrthoDBi60751at2759
TreeFamiTF101162

Enzyme and pathway databases

ReactomeiR-RNO-2299718 Condensation of Prophase Chromosomes

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR026971 CND1/NCAPD3
IPR032682 Cnd1_C
IPR012371 NCAPD3
PANTHERiPTHR14222 PTHR14222, 1 hit
PfamiView protein in Pfam
PF12717 Cnd1, 1 hit
PIRSFiPIRSF036508 Condns_HCP-6, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A140UHX3_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A140UHX3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 11, 2016
Last sequence update: May 11, 2016
Last modified: July 3, 2019
This is version 25 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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