UniProtKB - A0A140TA75 (A0A140TA75_HUMAN)
Protein
Carboxylic ester hydrolase
Gene
CES5A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- hydrolase activity Source: UniProtKB-KW
Keywordsi
Molecular function | HydrolaseUniRule annotation |
Protein family/group databases
ESTHERi | human-CES5A, Carb_B_Chordata |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CES5AImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:26459, CES5A |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 21 – 41 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 60 – 568 | COesteraseInterPro annotationAdd BLAST | 509 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
PhylomeDBi | A0A140TA75 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR002018, CarbesteraseB IPR019826, Carboxylesterase_B_AS IPR019819, Carboxylesterase_B_CS |
Pfami | View protein in Pfam PF00135, COesterase, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00122, CARBOXYLESTERASE_B_1, 1 hit PS00941, CARBOXYLESTERASE_B_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All
A0A140TA75-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVLVCPASC HGLKEFRIRR GMWRLCLVYY FYPASSTLYV LRIDVLNYTS
60 70 80 90 100
KDEGPSAEGP QRNTRLGWIQ GKQVTVLGSP VPVNVFLGVP FAAPPLGSLR
110 120 130 140 150
FTNPQPASPW DNLREATSYP NLCLQNSEWL LLDQHMLKVH YPKFGVSEDC
160 170 180 190 200
LYLNIYAPAH ADTGSKLPVL VWFPGGAFKT GSASIFDGSA LAAYEDVLVV
210 220 230 240 250
VVQYRLGIFG FFTTWDQHAP GNWAFKDQVA ALSWVQKNIE FFGGDPSSVT
260 270 280 290 300
IFGESAGAIS VSSLILSPMA KGLFHKAIME SGVAIIPYLE AHDYEKSEDL
310 320 330 340 350
QVVAHFCGNN ASDSEALLRC LRTKPSKELL TLSQKTKSFT RVVDGAFFPN
360 370 380 390 400
EPLDLLSQKA FKAIPSIIGV NNHECGFLLP MKEAPEILSG SNKSLALHLI
410 420 430 440 450
QNILHIPPQY LHLVANEYFH DKHSLTEIRD SLLDLLGDVF FVVPALITAR
460 470 480 490 500
YHRDAGAPVY FYEFRHRPQC FEDTKPAFVK ADHADEVRFV FGGAFLKGDI
510 520 530 540 550
VMFEGATEEE KLLSRKMMKY WATFARTGNP NGNDLSLWPA YNLTEQYLQL
560 570 580 590 600
DLNMSLGQRL KEPRVEFWTS TIPLILSASD MLHSPLSSLT FLSLLQPFFF
FCAP
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ6NT32 | EST5A_HUMAN | Carboxylesterase 5A | CES5A CES7 | 575 | Annotation score: | ||
E5RFG9 | E5RFG9_HUMAN | Carboxylic ester hydrolase | CES5A | 545 | Annotation score: | ||
A0A140TA60 | A0A140TA60_HUMAN | Carboxylic ester hydrolase | CES5A | 545 | Annotation score: | ||
A0A140TA78 | A0A140TA78_HUMAN | Carboxylic ester hydrolase | CES5A | 525 | Annotation score: | ||
A0A140TA61 | A0A140TA61_HUMAN | Carboxylic ester hydrolase | CES5A | 575 | Annotation score: | ||
A0A140TA72 | A0A140TA72_HUMAN | Carboxylic ester hydrolase | CES5A | 469 | Annotation score: | ||
I3NI11 | I3NI11_HUMAN | Carboxylesterase 5A | CES5A | 78 | Annotation score: | ||
F5H0J7 | F5H0J7_HUMAN | Carboxylesterase 5A | CES5A | 75 | Annotation score: | ||
A0A0J9YW16 | A0A0J9YW16_HUMAN | Carboxylesterase 5A | CES5A | 355 | Annotation score: | ||
A0A140TA65 | A0A140TA65_HUMAN | Carboxylesterase 5A | CES5A | 355 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007335 Genomic DNA No translation available. AC020766 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000573178; ENSP00000460799; ENSG00000261972 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC007335 Genomic DNA No translation available. AC020766 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
ESTHERi | human-CES5A, Carb_B_Chordata |
Genome annotation databases
Ensembli | ENST00000573178; ENSP00000460799; ENSG00000261972 |
Organism-specific databases
HGNCi | HGNC:26459, CES5A |
GenAtlasi | Search... |
Phylogenomic databases
PhylomeDBi | A0A140TA75 |
Miscellaneous databases
ChiTaRSi | CES5A, human |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR002018, CarbesteraseB IPR019826, Carboxylesterase_B_AS IPR019819, Carboxylesterase_B_CS |
Pfami | View protein in Pfam PF00135, COesterase, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS00122, CARBOXYLESTERASE_B_1, 1 hit PS00941, CARBOXYLESTERASE_B_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A140TA75_HUMAN | |
Accessioni | A0A140TA75Primary (citable) accession number: A0A140TA75 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 11, 2016 |
Last sequence update: | May 11, 2016 | |
Last modified: | August 12, 2020 | |
This is version 19 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |