UniProtKB - A0A140T913 (A0A140T913_HUMAN)
Protein
Submitted name:
HLA class I histocompatibility antigen, A alpha chain
Gene
HLA-A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Biological processi
- antigen processing and presentation Source: InterPro
- immune response Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: HLA class I histocompatibility antigen, A alpha chainImported |
Gene namesi | Name:HLA-AImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4931, HLA-A |
Subcellular locationi
Plasma Membrane
- plasma membrane Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 308 – 332 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
Cell membraneARBA annotation, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_5007305403 | 25 – 371 | Sequence analysisAdd BLAST | 347 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 125 ↔ 188 | Combined sources | ||
Disulfide bondi | 227 ↔ 283 | Combined sources |
Keywords - PTMi
Disulfide bondARBA annotation, GlycoproteinARBA annotationProteomic databases
PeptideAtlasi | A0A140T913 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 209 – 295 | Ig-likeInterPro annotationAdd BLAST | 87 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 337 – 371 | DisorderedSequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 349 – 365 | PolarSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the MHC class I family.UniRule annotation
Keywords - Domaini
SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
PhylomeDBi | A0A140T913 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog IPR001039, MHC_I_a_a1/a2 IPR010579, MHC_I_a_C |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit PF06623, MHC_I_C, 1 hit |
PRINTSi | PR01638, MHCCLASSI |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 31 potential isoforms that are computationally mapped.Show allAlign All
A0A140T913-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVMAPRTLV LLLSGALALT QTWAGSHSMR YFFTSVSRPG RGEPRFIAVG
60 70 80 90 100
YVDDTQFVRF DSDAASQRME PRAPWIEQEG PEYWDGETRK VKAHSQTHRV
110 120 130 140 150
DLGTLRGYYN QSEAGSHTVQ RMYGCDVGSD WRFLRGYHQY AYDGKDYIAL
160 170 180 190 200
KEDLRSWTAA DMAAQTTKHK WEAAHVAEQL RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRTDAPK THMTHHAVSD HEATLRCWAL SFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHVQHEGL PKPLTLRWEP
310 320 330 340 350
SSQPTIPIVG IIAGLVLFGA VITGAVVAAV MWRRKSSGGE GVKDRKGGSY
360 370
SQAASSDSAQ GSDVSLTACK V
Computationally mapped potential isoform sequencesi
There are 31 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP04439 | HLAA_HUMAN | HLA class I histocompatibility anti... | HLA-A HLAA | 365 | Annotation score: | ||
Q5SUL5 | Q5SUL5_HUMAN | HLA class I histocompatibility anti... | HLA-A HLA, HLA-A*0101 | 365 | Annotation score: | ||
Q53Z42 | Q53Z42_HUMAN | HLA class I antigen | HLA-A HLA | 365 | Annotation score: | ||
Q5SPM2 | Q5SPM2_HUMAN | HLA class I heavy chain | HLA-A HLA, HLA-A26 | 365 | Annotation score: | ||
B0UXQ0 | B0UXQ0_HUMAN | HLA class I histocompatibility anti... | HLA-A HLA | 365 | Annotation score: | ||
Q5RJ27 | Q5RJ27_HUMAN | HLA class I histocompatibility anti... | HLA-A HLA | 365 | Annotation score: | ||
Q5SRN5 | Q5SRN5_HUMAN | HLA class I histocompatibility anti... | HLA-A | 371 | Annotation score: | ||
A0A140T9X5 | A0A140T9X5_HUMAN | HLA class I histocompatibility anti... | HLA-A | 371 | Annotation score: | ||
A0A140T8Y4 | A0A140T8Y4_HUMAN | HLA class I histocompatibility anti... | HLA-A | 371 | Annotation score: | ||
A0A0G2JPD3 | A0A0G2JPD3_HUMAN | HLA class I histocompatibility anti... | HLA-A | 394 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR388205 Genomic DNA No translation available. CR388220 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000438861; ENSP00000388526; ENSG00000235657 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR388205 Genomic DNA No translation available. CR388220 Genomic DNA No translation available. |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6O4Y | X-ray | 1.58 | A | 25-298 | [»] | |
6O4Z | X-ray | 1.50 | A | 25-298 | [»] | |
6O51 | X-ray | 1.55 | A | 25-298 | [»] | |
6O53 | X-ray | 1.40 | A | 25-298 | [»] | |
6VQO | X-ray | 3.00 | A/F | 25-299 | [»] | |
6VR1 | X-ray | 2.37 | A/D | 25-299 | [»] | |
6VR5 | X-ray | 2.38 | A/D | 25-299 | [»] | |
6VRM | X-ray | 2.61 | A | 25-299 | [»] | |
6VRN | X-ray | 2.46 | A | 25-299 | [»] | |
SMRi | A0A140T913 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Proteomic databases
PeptideAtlasi | A0A140T913 |
Genome annotation databases
Ensembli | ENST00000438861; ENSP00000388526; ENSG00000235657 |
Organism-specific databases
HGNCi | HGNC:4931, HLA-A |
GenAtlasi | Search... |
Phylogenomic databases
PhylomeDBi | A0A140T913 |
Miscellaneous databases
ChiTaRSi | HLA-A, human |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.30.500.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011161, MHC_I-like_Ag-recog IPR037055, MHC_I-like_Ag-recog_sf IPR011162, MHC_I/II-like_Ag-recog IPR001039, MHC_I_a_a1/a2 IPR010579, MHC_I_a_C |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00129, MHC_I, 1 hit PF06623, MHC_I_C, 1 hit |
PRINTSi | PR01638, MHCCLASSI |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A140T913_HUMAN | |
Accessioni | A0A140T913Primary (citable) accession number: A0A140T913 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 11, 2016 |
Last sequence update: | May 11, 2016 | |
Last modified: | December 2, 2020 | |
This is version 24 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |