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Protein

Signal recognition particle receptor FtsY

Gene

ftsY

Organism
Escherichia coli (strain B / BL21-DE3)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi300 – 307GTPUniRule annotation8
Nucleotide bindingi382 – 386GTPUniRule annotation5
Nucleotide bindingi446 – 449GTPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorUniRule annotation
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle receptor FtsYUniRule annotation
Short name:
SRP receptorUniRule annotation
Gene namesi
Name:ftsYUniRule annotation
Ordered Locus Names:ECBD_0277Imported
OrganismiEscherichia coli (strain B / BL21-DE3)Imported
Taxonomic identifieri469008 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000002032 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membraneUniRule annotation, Cell membrane, CytoplasmUniRule annotation, Membrane

Interactioni

Subunit structurei

Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0A140N564
SMRiA0A140N564
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini467 – 480SRP54InterPro annotationAdd BLAST14

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili138 – 158Sequence analysisAdd BLAST21

Domaini

Contains an acidic N-terminal A domain, a central N domain and a C-terminal GTPase G domain that can bind and hydrolyze GTP. Contains at least two lipid-binding sites. The first site contains the first 14 amino acids (helix 1) and the second binding site is an amphipathic alpha-helix located at the interface between the A- and the N-domain (helix 2).UniRule annotation

Sequence similaritiesi

Belongs to the GTP-binding SRP family. FtsY subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

KOiK03110
OMAiGIEATDY

Family and domain databases

HAMAPiMF_00920 FtsY, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR027417 P-loop_NTPase
IPR013822 Signal_recog_particl_SRP54_hlx
IPR004390 SR_rcpt_FtsY
IPR036225 SRP/SRP_N
IPR000897 SRP54_GTPase_dom
PANTHERiPTHR43134:SF2 PTHR43134:SF2, 1 hit
PfamiView protein in Pfam
PF00448 SRP54, 1 hit
PF02881 SRP54_N, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00962 SRP54, 1 hit
SM00963 SRP54_N, 1 hit
SUPFAMiSSF47364 SSF47364, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00064 ftsY, 1 hit
PROSITEiView protein in PROSITE
PS00300 SRP54, 1 hit

Sequencei

Sequence statusi: Complete.

A0A140N564-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKEKKRGFF SWLGFGQKEQ TPEKETEVQN EQPVVEEIVQ AQEPVKASEQ
60 70 80 90 100
AVEEQPQAHT EAEAETFAAD VVEVTEQVAE SEKAQPEAEV VAQPEPVVEE
110 120 130 140 150
TPEPVAIERE ELPLPEDVNA EAVSPEEWQA EAETVEIVEA AEEEAAKEEI
160 170 180 190 200
TDEELETALA AEAAEEAVMV VPPAEEEQPV EEIAQEQEKP TKEGFFARLK
210 220 230 240 250
RSLLKTKENL GSGFISLFRG KKIDDDLFEE LEEQLLIADV GVETTRKIIT
260 270 280 290 300
NLTEGASRKQ LRDAEALYGL LKEEMGEILA KVDEPLNVEG KAPFVILMVG
310 320 330 340 350
VNGVGKTTTI GKLARQFEQQ GKSVMLAAGD TFRAAAVEQL QVWGQRNNIP
360 370 380 390 400
VIAQHTGADS ASVIFDAIQA AKARNIDVLI ADTAGRLQNK SHLMEELKKI
410 420 430 440 450
VRVMKKLDVE APHEVMLTID ASTGQNAVSQ AKLFHEAVGL TGITLTKLDG
460 470 480 490
TAKGGVIFSV ADQFGIPIRY IGVGERIEDL RPFKADDFIE ALFARED
Length:497
Mass (Da):54,513
Last modified:May 11, 2016 - v1
Checksum:iEBE640072B5D1021
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001665 Genomic DNA Translation: ACT27353.1

Genome annotation databases

EnsemblBacteriaiACT27353; ACT27353; ECBD_0277
KEGGiebd:ECBD_0277

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001665 Genomic DNA Translation: ACT27353.1

3D structure databases

ProteinModelPortaliA0A140N564
SMRiA0A140N564
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACT27353; ACT27353; ECBD_0277
KEGGiebd:ECBD_0277

Phylogenomic databases

KOiK03110
OMAiGIEATDY

Family and domain databases

HAMAPiMF_00920 FtsY, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR027417 P-loop_NTPase
IPR013822 Signal_recog_particl_SRP54_hlx
IPR004390 SR_rcpt_FtsY
IPR036225 SRP/SRP_N
IPR000897 SRP54_GTPase_dom
PANTHERiPTHR43134:SF2 PTHR43134:SF2, 1 hit
PfamiView protein in Pfam
PF00448 SRP54, 1 hit
PF02881 SRP54_N, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00962 SRP54, 1 hit
SM00963 SRP54_N, 1 hit
SUPFAMiSSF47364 SSF47364, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00064 ftsY, 1 hit
PROSITEiView protein in PROSITE
PS00300 SRP54, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A140N564_ECOBD
AccessioniPrimary (citable) accession number: A0A140N564
Entry historyiIntegrated into UniProtKB/TrEMBL: May 11, 2016
Last sequence update: May 11, 2016
Last modified: November 7, 2018
This is version 14 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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