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Entry version 33 (02 Jun 2021)
Sequence version 1 (11 May 2016)
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Protein
Submitted name:

Mucin 16

Gene

Muc16

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-913709, O-linked glycosylation of mucins
R-MMU-977068, Termination of O-glycan biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Mucin 16Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Muc16Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1920982, Muc16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8423 – 8449HelicalSequence analysisAdd BLAST27

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34Sequence analysisAdd BLAST34
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500730321735 – 8478Sequence analysisAdd BLAST8444

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
A0A140LJ72

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0A140LJ72

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
370009

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
A0A140LJ72, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000034653

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
A0A140LJ72, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A140LJ72

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6178 – 6299SEAInterPro annotationAdd BLAST122
Domaini6312 – 6372SEAInterPro annotationAdd BLAST61
Domaini6419 – 6540SEAInterPro annotationAdd BLAST122
Domaini6571 – 6690SEAInterPro annotationAdd BLAST120
Domaini6722 – 6843SEAInterPro annotationAdd BLAST122
Domaini6856 – 6977SEAInterPro annotationAdd BLAST122
Domaini6988 – 7109SEAInterPro annotationAdd BLAST122
Domaini7135 – 7256SEAInterPro annotationAdd BLAST122
Domaini7269 – 7390SEAInterPro annotationAdd BLAST122
Domaini7425 – 7542SEAInterPro annotationAdd BLAST118
Domaini7577 – 7694SEAInterPro annotationAdd BLAST118
Domaini7729 – 7846SEAInterPro annotationAdd BLAST118
Domaini7879 – 7996SEAInterPro annotationAdd BLAST118
Domaini8030 – 8147SEAInterPro annotationAdd BLAST118
Domaini8164 – 8275SEAInterPro annotationAdd BLAST112
Domaini8289 – 8409SEAInterPro annotationAdd BLAST121

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni283 – 320DisorderedSequence analysisAdd BLAST38
Regioni416 – 439DisorderedSequence analysisAdd BLAST24
Regioni557 – 577DisorderedSequence analysisAdd BLAST21
Regioni680 – 708DisorderedSequence analysisAdd BLAST29
Regioni717 – 736DisorderedSequence analysisAdd BLAST20
Regioni760 – 791DisorderedSequence analysisAdd BLAST32
Regioni878 – 897DisorderedSequence analysisAdd BLAST20
Regioni914 – 980DisorderedSequence analysisAdd BLAST67
Regioni1005 – 1050DisorderedSequence analysisAdd BLAST46
Regioni1204 – 1236DisorderedSequence analysisAdd BLAST33
Regioni1352 – 1378DisorderedSequence analysisAdd BLAST27
Regioni1406 – 1427DisorderedSequence analysisAdd BLAST22
Regioni1538 – 1579DisorderedSequence analysisAdd BLAST42
Regioni1634 – 1657DisorderedSequence analysisAdd BLAST24
Regioni1705 – 1724DisorderedSequence analysisAdd BLAST20
Regioni1729 – 1754DisorderedSequence analysisAdd BLAST26
Regioni1853 – 1873DisorderedSequence analysisAdd BLAST21
Regioni1911 – 1934DisorderedSequence analysisAdd BLAST24
Regioni2298 – 2320DisorderedSequence analysisAdd BLAST23
Regioni2459 – 2485DisorderedSequence analysisAdd BLAST27
Regioni2824 – 2853DisorderedSequence analysisAdd BLAST30
Regioni3141 – 3179DisorderedSequence analysisAdd BLAST39
Regioni3749 – 3775DisorderedSequence analysisAdd BLAST27
Regioni3868 – 3894DisorderedSequence analysisAdd BLAST27
Regioni3938 – 3969DisorderedSequence analysisAdd BLAST32
Regioni4218 – 4246DisorderedSequence analysisAdd BLAST29
Regioni4475 – 4508DisorderedSequence analysisAdd BLAST34
Regioni4583 – 4602DisorderedSequence analysisAdd BLAST20
Regioni4660 – 4685DisorderedSequence analysisAdd BLAST26
Regioni4708 – 4729DisorderedSequence analysisAdd BLAST22
Regioni5089 – 5132DisorderedSequence analysisAdd BLAST44
Regioni5208 – 5227DisorderedSequence analysisAdd BLAST20
Regioni5335 – 5366DisorderedSequence analysisAdd BLAST32
Regioni5407 – 5437DisorderedSequence analysisAdd BLAST31
Regioni5626 – 5659DisorderedSequence analysisAdd BLAST34
Regioni5996 – 6047DisorderedSequence analysisAdd BLAST52
Regioni6098 – 6164DisorderedSequence analysisAdd BLAST67
Regioni7841 – 7875DisorderedSequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi878 – 896Polar residuesSequence analysisAdd BLAST19
Compositional biasi914 – 978Polar residuesSequence analysisAdd BLAST65
Compositional biasi1216 – 1236Polar residuesSequence analysisAdd BLAST21
Compositional biasi2301 – 2320Polar residuesSequence analysisAdd BLAST20
Compositional biasi3938 – 3956Polar residuesSequence analysisAdd BLAST19

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RD3J, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00440000039287

Identification of Orthologs from Complete Genome Data

More...
OMAi
SHRQFNS

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.960, 17 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028850, MUC16
IPR000082, SEA_dom
IPR036364, SEA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR14672, PTHR14672, 13 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01390, SEA, 16 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82671, SSF82671, 16 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50024, SEA, 16 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

A0A140LJ72-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGEEDVACSA HRHRHRYLLT LTTSLLLAYG PASAFQEPHS SSGPMTSVLR
60 70 80 90 100
PIPKTNTRKL DTSTTVTAST LHWRSNIPSK LAAMKGTRNS KKAVNIINST
110 120 130 140 150
SSTPDVTFGS VLLKTTLSTK IPETTGKSTG YPSMTTSNFT RTETHNGTAL
160 170 180 190 200
NSTLLSDTST TVTVAETNIT EIISTTEHTP NFTEVPFTNS VLVSRTESTN
210 220 230 240 250
NSISYPITNQ VIKAEEISTG MPTGPPNSII SKEITTSQIE HFVVTPNIIA
260 270 280 290 300
SQGIPATTSG AGMHSSVSHN YSLLETSTLL KSDKVPSRTN SSPLEGISSE
310 320 330 340 350
SSWKTTVRTS SSSPVKLSSQ RHLPITHHTT KQSWTTAQIQ SSTLEEVDLI
360 370 380 390 400
TEYSLNHTEV PMNLSLLEPS TKDMSTGNIS FTTLHESISE DTSFGITIGT
410 420 430 440 450
PSSSITSKLQ QLSNSHNGHS VVTSSMVTSK SPSTSASINV TNSSRVQTFP
460 470 480 490 500
HPEAMDPPKN ITSGPQTHNL WEESVFEDST MPHESHSPSA ISSIRDTHST
510 520 530 540 550
SFTGSVAYVI TVSKDTIPTD LSTRSEPVIS SIQSLNGSPQ KSFNIAQVSK
560 570 580 590 600
ISQMTSVSSV TKGNKKNGSS TPKLKHTIIP TPISSEHEYF TTILARSEDT
610 620 630 640 650
TLSSPQSISF TTAEIGKPTD SSLMKAWKSS SKYEDIHSTK EHRISQTNVP
660 670 680 690 700
TTLSLVTSVA KDISAGSTFL SKLHHSISED TSTGISTKYS RSTTTTESEQ
710 720 730 740 750
TATSHREHTV VTSNMVTSKD LSTTSSNTET QHSGTQTFTL SESMVNSTNI
760 770 780 790 800
NPATTLRTNS VWEGSMPTSS TRTPDEAPSH SPVSANADRY STPSSVSASI
810 820 830 840 850
VTISKEPNPT RLYVIPKSVT PSIPSSNSTQ FSKIPQTTSV SLLGSVEGMK
860 870 880 890 900
KSTFKHAITP ISVSLEKESF TTILPTMEQA RLSPSQSVSS ERTDTERGIS
910 920 930 940 950
FPLRTAWTDF STSEQINTST EYSTSHTELS TSPSPLESRT GLTSADSISI
960 970 980 990 1000
SDLQSTLQDT SSGTSISIPA STVSAESEEM KSRPMGLYPV ISDILTYPDS
1010 1020 1030 1040 1050
SSTVSVKGTH SSGTHTFPHS ESRAPFNNLA SASWTPTPEK GTISTDSTKT
1060 1070 1080 1090 1100
QESLSLTADT YMPHTHSSHS PDSVVSFFTS SKDSIPTDSY TSLGPVTVYV
1110 1120 1130 1140 1150
PSWSSTSQSS SNTVHASQMS QMNTFSSVTS GSNMGDSHSV PEFKYTTTSV
1160 1170 1180 1190 1200
SVPSELSTEK KTFPTTLPTT EVATLIPTKS TSYENTSSGT KTVTLLTTLT
1210 1220 1230 1240 1250
QANSPEKVHS STDFIRHPSE VPNSSSTPVS STRSMSPDNA ILPTLWHFTS
1260 1270 1280 1290 1300
EHTGFTPEDM TSGTVTKCYD SNTITESQEV STSQIRDSNV TSNIALSLKT
1310 1320 1330 1340 1350
STMSSESDNF MSFSPAPTIT ETSTFVSQSY EVPSIATFST LKGSPLGNSP
1360 1370 1380 1390 1400
GYLNESSLTS SVTSTGENNT PSPSPVVSVF TSSKEKITTR LDKPLHNLST
1410 1420 1430 1440 1450
SFSNWTTNTH TSQETSQATE FSQTSSASSV NSEIITEVSS SIPQPKFSVS
1460 1470 1480 1490 1500
ESIRAGRTLT RSPLYSSESE DITPGSISRL ITYPSTEHIG LTSIFGTANS
1510 1520 1530 1540 1550
GSLLSDSLSR DIAATVPMKE FSSPEPQTSP HLSWISESHS FEEQSQTSSL
1560 1570 1580 1590 1600
SKGKHTSTDP TSTMIEKTTL SPVTSTSQGQ NVSSLDFLAA LVTSIHETNS
1610 1620 1630 1640 1650
NGQDTSATSG SNSIQSLDTI GLSTPGSSYN MKTFQTSHIS PKNPATRVET
1660 1670 1680 1690 1700
DSPAMHPQGT VLVNSVPSRI TEIMISQSNW DTISPSMPLS SPVHAETQKA
1710 1720 1730 1740 1750
FPITSIEQET TRSEDTDLMK KHSSGLLTVS TSTYPGISRT EANSTDTTST
1760 1770 1780 1790 1800
SNSVSFAKTT DTSVGNASSS STLFFPRTDI SQVVNVEESS NITTLLNTSD
1810 1820 1830 1840 1850
PITYSGALST VTQTFLHSDS ISHPSSSELL SWTDSPLHEA TSSVNSIETI
1860 1870 1880 1890 1900
HTSSFPVTSP SEGQGLFFPS SEETTTEELD TNLAFFKTSF PSWSNSELAI
1910 1920 1930 1940 1950
SKDTRTSQKS YNSTKTEVSP VNITTSEPPA QYTVSPETLS ADSTASSLLI
1960 1970 1980 1990 2000
IPTKISASAS PLLPQRSNST SFPKTSFPTS ELFKTTDILD RSLETGISLP
2010 2020 2030 2040 2050
PNLRSTSLEI LGLSEVVTDT EKHHSSSSFT VTNVNTITVG HELSSSVSTL
2060 2070 2080 2090 2100
SESSRDADTS GTPPSVWVTT ILTSLPNHLE TTRSNTDSFS HLTSGLRDTS
2110 2120 2130 2140 2150
ISLQTNKPSP LESTLHLPSS ETDVATAVNI PTPYQSPSPK FTDIPIATAT
2160 2170 2180 2190 2200
ILNPSSSIVE STGATSFPEY DFTMLSRENI HVPRTDILPS AETTLIDTTA
2210 2220 2230 2240 2250
TLSPRGMTFF ATTSNPTGIS AVTSESSHSM IQSSHLFATI VKKPPSSIST
2260 2270 2280 2290 2300
PLPYPISTTT DTAASSSLQR ITTPSEMEDG MQYHTDISNG AVHGDTAGLG
2310 2320 2330 2340 2350
KGSLASTSSA NHKDLTTEGT VKADTTTRAL KASSIFTPNT KMSTTISTPP
2360 2370 2380 2390 2400
THIKTSKKTT NINTTEMIIT ASDASHNLLE MAPSFSTGLR ENISMVARTS
2410 2420 2430 2440 2450
PSSYSRKPEI TIPQIPSLKT KTIPNVNTLT VSSAESDTIS WITHALEITS
2460 2470 2480 2490 2500
AIAKTTKNAS QVELDSKVST ATSSRGKDRS TLSTAAVSSA IPDLASIEQE
2510 2520 2530 2540 2550
DRLFGPTISI SSSIPDMKNL EGYSSKEDIG TSKPILTHSP SEPYNTISLI
2560 2570 2580 2590 2600
SHAGGKTDSP MSTIAVSPDV TEIMRPLFTS SGRRIHTRNP TQGQSVTTSW
2610 2620 2630 2640 2650
ITHPGTEATS RVLTTTISPN NQEVETSKSA NPSKLQTTTS LITDSKEQPS
2660 2670 2680 2690 2700
FTMSTLAVSL GVIEGTPSPV INRGTERNSR TATLDFFLDL PETTTSWTTN
2710 2720 2730 2740 2750
PEKEAISGIL TTKYAPSVTD RMTTINLNHT PPEPQNITSL ATHYVRHSLI
2760 2770 2780 2790 2800
TSTKVVHPDI EEVKPSQVTS SVTESHVMTS NMAFSPGKHE TINPFVTHPR
2810 2820 2830 2840 2850
RKVTSGILTA AISPSVTNMM TFTPVKHSPS EPQPIESLDT NAEGHPSASM
2860 2870 2880 2890 2900
STQALSPGMR EMMIPQAPNY GRETYITTST LPVSVGQIES TASLVTHAEK
2910 2920 2930 2940 2950
EATLGVLPTT VSTISPNMMA STELMSSGPH TTASLVTHNG EQHSSDMSTL
2960 2970 2980 2990 3000
PASSGITKIK QSLDTTTGKE SQSVITTLAV SLGIPKTKSI NTTSNVPDMM
3010 3020 3030 3040 3050
ISKSWNHTSS NVHTITSLVT HAGTQSSFSK STKAASPSIT KLTASLFTDT
3060 3070 3080 3090 3100
DTENVAITAL PTSSGQMEKR APSVTKPEKE TISDVLSITT STSVQQMMIS
3110 3120 3130 3140 3150
PTVIPSEPHT TVSFDTHVGG QPSSTMSILP VTSDSTKIIS SLGTRSGTES
3160 3170 3180 3190 3200
HSVTSTMDIS QGQLETTASG DTHTEREGNS LTLSTVISTS APDIMTSTNE
3210 3220 3230 3240 3250
NQTSSDRQTI ISLLTLAGED TSLSVPSQGG SPGIMKVTPS LFTDVGTEGY
3260 3270 3280 3290 3300
AITSTLPVFS GQPDTRTPWD KHSETKVTTV VLPTTISTSV PEIMTSPTPI
3310 3320 3330 3340 3350
PSEAHTTVSL ITHAGGAPSL AMSTLPVSGA LTENIPSKVT YRGKEGNSVT
3360 3370 3380 3390 3400
SALDVSWDQK ESTAPWVSYQ AKEGPSEVLS TNISTRAPDM VFSTNKNQTS
3410 3420 3430 3440 3450
SDTQTMTSLI TQTGEQTSLS ESTQGVSSAI TKMTQSIFND LGTESYEMTS
3460 3470 3480 3490 3500
TLPASSHQSE TRTKWITHSK IEQMSGVLST TNSSSAPKMM TSTPITSELH
3510 3520 3530 3540 3550
ATVSLVTHVG AQHSSTMSAL TASPGKTEIM PSEQTHTGTE IHSVTSTLDV
3560 3570 3580 3590 3600
SAGQEELTTA WVTQSEKERT SGVLSTAISL SVPNMTSATL NNNSLDIRTI
3610 3620 3630 3640 3650
TAFMKHPAGK SSLSMSTEGI SPRITEVTPS LFTDLGTESY AMTSTMPASS
3660 3670 3680 3690 3700
GQSETRKSWN TNSEMEATPG VLSTSITTNV SEMITSSTSF PSEPHTTVSL
3710 3720 3730 3740 3750
VTQLGGNSSS PMSALPASPG RTEIKSSLVT YPDTESYSVT STLDIFTGEA
3760 3770 3780 3790 3800
ESTTPASTHT GREGTSETVT RNTSTSVPDM MTSITKRHSA SNTQIMESLV
3810 3820 3830 3840 3850
DSMEIHHGGK PSLSVSSQHV TPDITEVTQS LFTNLGYERN TVIPTLPVSP
3860 3870 3880 3890 3900
GQPDTQATWV IHSEKEATSR VLPTSTSPHV SEPKASPTDI PSEPQNTVSL
3910 3920 3930 3940 3950
LTQVGGQSSS AMYILQTSTG RTKIKPSVVT QPGTESFAML STPDISQGQT
3960 3970 3980 3990 4000
ESATPWPTHP PKKGTSEVLS TTISNSSPAT MTSITKNQTS FDSQNITSFI
4010 4020 4030 4040 4050
THAEVQPSLS VSMQDISTGK AKVSTSQFTD LGRENCAMTS MLPALSGQVE
4060 4070 4080 4090 4100
TKAPWDTNSE MEGIFGPVST IISSSVPEMM TSPNVIPSEP HTKVPLSNHD
4110 4120 4130 4140 4150
VGQPTSIMST LHVLPSIPEF KPKLDTSYGA ESQSLTSTMG IFVDQARSTN
4160 4170 4180 4190 4200
TWATHTGRKD TSGIESRLIS TSAPEMMTSI TKNQTSSETK TITPYVIQAG
4210 4220 4230 4240 4250
GESTSGTVSK IISTSAPEKM NSVTKNQTSS DTQITHAGEQ PSLSVSTQDI
4260 4270 4280 4290 4300
SPRITEVIPS EFTDIGPKRF AMTSTLPASP GQAETNGTIT PWNSNSEMEA
4310 4320 4330 4340 4350
TSGPLSTTIL PGVQEMMTSP SVFPSEQQTT VPLVSHYVGQ PTSVMSTLPF
4360 4370 4380 4390 4400
SPGRTENMPS LVSSSGIQSH SVTSIKDTSV NKAVSTTTWA THTGRENTSG
4410 4420 4430 4440 4450
TESTLISTSA PETITSITKH QTSADTQTIM SFITHPAGQP SLSVSPYGAS
4460 4470 4480 4490 4500
PGITVVTPSQ FSDLGTESYA MASTLPASPG QAESKTPWDT HSEMEATSGP
4510 4520 4530 4540 4550
VPTTISPGVL ETMTSPTVIP SEPPTKVPLV THVVGPSTSS MSTLHVSPGI
4560 4570 4580 4590 4600
PEITPSVVTS YGPESHSATS TQVISIDQAG STTTWSAHTG RGNTSGTEST
4610 4620 4630 4640 4650
LISSSGSEMM TSIKKIQTSS ETQTITSFIT HAGGESTSGT VSTVISTSAP
4660 4670 4680 4690 4700
EMVNSLTKNQ TSSDTQITHA GEQPSLSVST QDVSPRITEV TPSEFTDLSS
4710 4720 4730 4740 4750
NNYAMASTLP SSPGLEETKT PWNSNSEMEA TSGHLSTTIS HGVPQMMTAT
4760 4770 4780 4790 4800
TVIPSQPHST LPIVTHIPGQ QTSVMSIFPF SPGRTERMPS LFPSPSRENH
4810 4820 4830 4840 4850
LVSSTQDISI DQAVSTTPWP NHTGNKITSG TKSTLISTSS AETMTSITKN
4860 4870 4880 4890 4900
QTSSATQTSF ISHAAGESSL SGSTYGVSFG ITQLSPSQFT DLGTKNYAMT
4910 4920 4930 4940 4950
STFPASPSEI ETKAPWNTNS KMEASSGPLS TTISSGVSEM RTAPTVASSE
4960 4970 4980 4990 5000
THTKVALVTH IIGQLTSVGS TLPFSSGKIE NMPSLVSSSG IQSHSGTSIQ
5010 5020 5030 5040 5050
DTSVNQAVST TTWATHTGRE NTSGTESTLI STSAPETITS ITKHQTSSDT
5060 5070 5080 5090 5100
QTITSFITHS AGQPSLSVSP YGASPGITVV TPSQFSDLGT ESNTMTSTLP
5110 5120 5130 5140 5150
ASPGQAESKT PWDTHSEMEA TSGPVPTTIS PGVLETMTSP TVIPSEPPTK
5160 5170 5180 5190 5200
VPLVTHVVGP STSSMSTLHV SPGIPEISPS VVTSYVPESL SVASTMSIFI
5210 5220 5230 5240 5250
DQAGSTTTWS AQTGRGNTSG TESTLLSTSA PELMTSLTRN PNSSETEAIT
5260 5270 5280 5290 5300
SFITHPGEES TSGTVSTIIS SRAPDVMTSV TKNQTSSETQ TITSFITHHG
5310 5320 5330 5340 5350
GQPSLSVSTQ GVSPRITVVT PSEFTDLSSK SYAMTSSLPT SPGLEETKTP
5360 5370 5380 5390 5400
WVSSSELEAT SGPLSTTILP GVQEMMTSPS VFPSEQQTTV PLVSHYVGQP
5410 5420 5430 5440 5450
TSVMSTLPFS PGRTESIPSV FPSSGTESHS VTSTQDTSID QAVSITPWST
5460 5470 5480 5490 5500
LTGRGHTLGT ESPLISTSAP ETITSITKNG TSSDTQTITS FITHHGGQPS
5510 5520 5530 5540 5550
LSVSTQGVSP GITEVTLSQF TDFSTKNYAM TSTLPASPGQ AESKTLWNTN
5560 5570 5580 5590 5600
SEMETNSGPL SSTISSVVQE MMTSPTVISS EPHTNVPLVS SDVVQSSSSM
5610 5620 5630 5640 5650
STLSVSPGTP EITPSVVTSY VSESHSLPST LPVSSSQSKS PAQWITHTGH
5660 5670 5680 5690 5700
EGASGNLSPT ISPSVPEIMT VTTLNHTLPK SLTITSLSTQ VGVQPSLNRT
5710 5720 5730 5740 5750
TTAFSPSIPK LTSLSTNLGI ESHHTTVSLS PSLSETIASL VTHSQKEASL
5760 5770 5780 5790 5800
GVLTTTIPST ILDTMTSPSL LTSESYTTIS LTTPLEGQPS SSMSTLAVSP
5810 5820 5830 5840 5850
GVTEKIPLLV TSSSTNTHSV SSTLHASPGQ LETPALMVTP PEREATSSIL
5860 5870 5880 5890 5900
RTDISPSIPD LMASKTHNPS EHTTISSVTY VGGQSSPSIS TLTKFPSIKD
5910 5920 5930 5940 5950
IMTPLATTSV VETHKTAPTL SVPADQRETT ALWVIHSGKE LMSTVSSPPT
5960 5970 5980 5990 6000
LPGDSERTET WLILSAKTST PHPTITSTFS YNDITSSVSE VETSSATTLS
6010 6020 6030 6040 6050
SGASEEAASL SGHTGTETST STLTVTPSST SPGTTGLQPS SPSKEYTLTM
6060 6070 6080 6090 6100
SSSLPVFPDH STTSKFGIAT SKNIETSPSL STVRLSDFVS DVISPAMTLS
6110 6120 6130 6140 6150
SESSTHAPTD LETTRETTHS ATTSSKPTGD KTTTSLHESS SALLTTRRIS
6160 6170 6180 6190 6200
TLSPENVTSR PSYHHQYWTP KTSTTNPSLV PFTLNFTITN LHHTEGMASQ
6210 6220 6230 6240 6250
GSEIFNSTER ILNSLLKPMF KNSSIGHLYS GCRLITLRPE KDGTATGVDA
6260 6270 6280 6290 6300
VCTLHSDPLG LQLDREKMYW ELSHNTQGVT KLGSFTLEKD SLYINGYTHQ
6310 6320 6330 6340 6350
IQSITSPMPL SSLVPFTINF TITNLKYEEG MNHPGSWKFN ATERILQRLL
6360 6370 6380 6390 6400
WPLFNKTSIS LRYSNCRLAL LSERVFWELC NLTNNVTQLG PYTLDKNSLY
6410 6420 6430 6440 6450
INGYTHQIQS ITSPTAGPVL EHFTINFTII NLKFEEDMSH PGSRKFNITE
6460 6470 6480 6490 6500
RTLQRLLRIL FKKSSVGALY SGCKLSLLRP ENDGAGTGVD AVCTHYPDPT
6510 6520 6530 6540 6550
GLGLDRKMLY GEISRLTYGV KRLGPYTLND KSLYVNGYTH QIVATTTQMA
6560 6570 6580 6590 6600
MMTIASMGMI NNSPSPTAGS GLVPFTINFT VTNLKYVENM HHPGSRKFNT
6610 6620 6630 6640 6650
TERILQKLLK ALFSKTSVGP LYSGCRLILL RLEHNGTATG VDAICTYHPN
6660 6670 6680 6690 6700
ISNQGLDRER VYWELKRLNI TQLGPYIVDE NSLYINGYTQ QILSTTSRPS
6710 6720 6730 6740 6750
VMATVSEGMP NISSTPTATS PVLVPFTINF TITNLEFKKD MGRPGSRKFN
6760 6770 6780 6790 6800
VTERTLQSLL RPLFIKTSVG QLYSGCRITL LRPEKNRAAT GVDATCTYHL
6810 6820 6830 6840 6850
DPAGHRLESE QIYEELSNLT QSVTQLGPYI LDQNSLYVNG YTDQILATTP
6860 6870 6880 6890 6900
RALSSALLRC TLNFTITNLP HTNDMWVPGS AKFNKVEKIL KLLLKPLFQN
6910 6920 6930 6940 6950
TSVGLLYSGC RLTSLRPKKD GEATRVDMVC TYHPNTTGTG LDREQLYLEL
6960 6970 6980 6990 7000
EQLTHNITQL GPYSLDQNSL YVNGYTHQTA VTSPSKSPLE IFTFNFTITN
7010 7020 7030 7040 7050
LLYTENMQPP GSKKFNTIEK ILQGLLGSLF KNTSIGPLYT GCRLTSLSSR
7060 7070 7080 7090 7100
KDGKATEVDT VCSYYADHMG PGLATEQLYL ELSNLTHGVT KLGPYTLDQD
7110 7120 7130 7140 7150
SLYVNDYTYS ASSIFHNTSS LVPYSTNNST GNGTVMVSIT LNFTITNLHY
7160 7170 7180 7190 7200
TEEMGHPGSL KFNSTKWTLH YWLDTLLNKT SIAPLYSGCR LASLRSDDHR
7210 7220 7230 7240 7250
AATEVDVICN FHSYSMSPGV NQDQLFWELS HGTHGITHLG PYTLDQNSLY
7260 7270 7280 7290 7300
INGNSFGAAA PNTTTGELSE ELFTVNFTIN NLRYSADMSQ IGSPKFNITD
7310 7320 7330 7340 7350
TLMQHLLGPL FQRSSLGPLY TGCRVATLRS MKNGAQTQVD VLCTYRRVFN
7360 7370 7380 7390 7400
SQGLPAKPIF YDLSWQTHGI TKLGPYSLDK DSLFINGYNE PGPDVPPTTP
7410 7420 7430 7440 7450
EPATTILPSP TTSLQPESNT VMWHKPETFT INFTISNLPY SVDMISGSAI
7460 7470 7480 7490 7500
FNSTENVLQR LLGPLFQNDS FNSSCRLTSL RPEKNGMFTG VVTTCTYQND
7510 7520 7530 7540 7550
PAHPGMDIQG LYSELSHLSH GVTQLGNYTL EEHSLYVNGY PILGPDILTT
7560 7570 7580 7590 7600
TPEPSTTILP FTLTSVQPES TTARAHHLKT ITINFTISNL PYSAEMNYSS
7610 7620 7630 7640 7650
AMFNSTESVL QHLLRPLFQN NSFNASCRLT SLRPEKNQNS TNVNVICSYQ
7660 7670 7680 7690 7700
HYSAHPGLHT QELYSELSHL THGFTQLGNY TLDKDSLYVN GYNEIGTKEP
7710 7720 7730 7740 7750
TTNPETATTM LPSPSILVQT ESTTAVGYHL KTVTVSFTIS NLPYSAHMNN
7760 7770 7780 7790 7800
GSAVFNSTET VLKHLLEPLL HNGSFNSSCR LDSLRPEKNG TATAVEAICT
7810 7820 7830 7840 7850
YYHNAANSGI DTQELYSELS HLTYGITQLG NYTLDQESLH VSGYNEPHPE
7860 7870 7880 7890 7900
EPPTTPEPTT TMQPSPSTAL HPEPTTGHHL KILTINFTIS NLPYLSNMSN
7910 7920 7930 7940 7950
GSAMFNSTES VVQYLLSHLF QNGSFNSSCT LDSLRSRKNG TATGVNVICI
7960 7970 7980 7990 8000
YHHDPENPEM DIHGLYLEIN NLTHGITQLG NYSLDNGSLY INGYNEHGVE
8010 8020 8030 8040 8050
ELYTAPESPS TIVPSSSTFV KGEPTVAMGN LKTFTLNFTI SNLPYSTDMS
8060 8070 8080 8090 8100
SGSAMFNSTE RILQHLIRPL VQNESLYSNC RLASLRPKKN GTATGVNAIC
8110 8120 8130 8140 8150
SYHQNPDHPE LDTQELYTKL TQLTQGVTQL GSYMLDQNSI YVNGYTHQTA
8160 8170 8180 8190 8200
ETTSSGYVPL NITIQGKYQL NFCIINWNLN NTDPTSSEYI TLERDIEDKV
8210 8220 8230 8240 8250
TTLYTGSQLK EVFQSCLVTN MTSGSTVVTL EALFSSHLDP NLVKQVFLNK
8260 8270 8280 8290 8300
TLNASSHWLG ATYQLKDLHV IDMKTSILLP AEIPTTSSSS QHFNLNFTIT
8310 8320 8330 8340 8350
NLPYSQDIAQ PSTTKYQQTK RSIENALNQL FRNSSIKSYF SDCQVLAFRS
8360 8370 8380 8390 8400
VSNNNNHTGV DSLCNFSPLA RRVDRVAIYE EFLRMTHNGT QLLNFTLDRK
8410 8420 8430 8440 8450
SVFVDGYSQN RDDDVMKNSG LPFWAIILIC LAVLLVLITC LMCCFLVTVC
8460 8470
RRKKEGDYQV QRHRLAYYLS HLDLRKLQ
Length:8,478
Mass (Da):908,733
Last modified:May 11, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6EE5D3678FDE0051
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LI05A0A140LI05_MOUSE
Mucin 16
Muc16
2,566Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q9D1H1Q9D1H1_MOUSE
Mucin 16
Muc16
258Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140LIA5A0A140LIA5_MOUSE
Mucin 16
Muc16
366Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000208663; ENSMUSP00000147104; ENSMUSG00000109564

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

SMRiA0A140LJ72
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034653

Proteomic databases

jPOSTiA0A140LJ72
PaxDbiA0A140LJ72
ProteomicsDBi370009

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
3492, 1039 antibodies

Genome annotation databases

EnsembliENSMUST00000208663; ENSMUSP00000147104; ENSMUSG00000109564

Organism-specific databases

MGIiMGI:1920982, Muc16

Phylogenomic databases

eggNOGiENOG502RD3J, Eukaryota
GeneTreeiENSGT00440000039287
OMAiSHRQFNS

Enzyme and pathway databases

ReactomeiR-MMU-913709, O-linked glycosylation of mucins
R-MMU-977068, Termination of O-glycan biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Muc16, mouse
RNActiA0A140LJ72, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

ExpressionAtlasiA0A140LJ72, baseline and differential

Family and domain databases

Gene3Di3.30.70.960, 17 hits
InterProiView protein in InterPro
IPR028850, MUC16
IPR000082, SEA_dom
IPR036364, SEA_dom_sf
PANTHERiPTHR14672, PTHR14672, 13 hits
PfamiView protein in Pfam
PF01390, SEA, 16 hits
SUPFAMiSSF82671, SSF82671, 16 hits
PROSITEiView protein in PROSITE
PS50024, SEA, 16 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A140LJ72_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A140LJ72
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 11, 2016
Last sequence update: May 11, 2016
Last modified: June 2, 2021
This is version 33 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
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