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Entry version 24 (16 Oct 2019)
Sequence version 2 (20 Jun 2018)
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Protein
Submitted name:

Predicted gene, 35339

Gene

Gm35339

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Predicted gene, 35339Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gm35339Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:5594498 Gm35339

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
A0A140LHH9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini294 – 376WD_REPEATS_REGIONInterPro annotationAdd BLAST83

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni892 – 915DisorderedSequence analysisAdd BLAST24
Regioni1118 – 1156DisorderedSequence analysisAdd BLAST39
Regioni1522 – 1559DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1118 – 1136PolyampholyteSequence analysisAdd BLAST19
Compositional biasi1530 – 1554AcidicSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

WD repeatPROSITE-ProRule annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163397

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit
SSF50978 SSF50978, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A140LHH9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDRLIETGN LYSSEGDHLP LDVDIYDHDI YDIPDPGVLI EKNELGLLGG
60 70 80 90 100
PQVPHLFTNS QRWQNMSLRR RARLLWLHLR AYLHDIVEKE KRAELRVARM
110 120 130 140 150
THGLEPLRHL EVEAGLCSVA QDPVGERFMV LDGEGYLHQH TKDGWEQAKL
160 170 180 190 200
KPPVILNGLV TVPGPLGEIG RFVGWGPAGL SILGPDFHLL WLSKPRVNKS
210 220 230 240 250
LDQEPFCCLP VPSLSLLIVA QMGGSLELWK FRSGGRCLVP CGSPLRPPPG
260 270 280 290 300
LSGSFKCLAL GLEPDHCSWH CFAAYGSAVL TFDLDDWALI NVSQDLHKTI
310 320 330 340 350
ISDLDYCEEM DAMVTASRDS TVKVWEADWQ IRMVFVGHTG PVTAMTVLPN
360 370 380 390 400
STLAVSASQD GTIRTWDLRA AAQVGEVTLG CWTEDIISEK VSHLLAPASP
410 420 430 440 450
GWPVLSLCSK SIELWRVRTL YSPLAQLSAP VLHIQVAPVL PAPTDPSLPA
460 470 480 490 500
RLVCACADGS VHLVSATTGR TVSSLLLEPE DCAAGVAYCL SREALWVLTR
510 520 530 540 550
SGHLVRANAA RCPMVVVHRL RPPPPPAPQP CCLHLYSHLT DSRSAFACWE
560 570 580 590 600
IVRQNQGDML RSAIAWAWKN KNRFLPVMGH SDGTLSVLDW RTSVTVFHTE
610 620 630 640 650
AHSPGPVTAI GSTWSSIVTS GGDLTVKMWR VFPYAEECLS LLQTFSCCHP
660 670 680 690 700
VVMLCVLGKR ITAGFEDPER ATYGLVQFGL GDKMRCDHRP QDDPMDHITG
710 720 730 740 750
LCCCPTLKIF ACSSLDCTIR IWTRENHLLR LLQLDGPPQA LAFASNYGDL
760 770 780 790 800
VFSLGSRLHL VSYSTYLPTS YLVKKLCLKA SDVISDPPLP LTSKKPLTSS
810 820 830 840 850
QLQRLANLRG AASLSVALPF GYYKRSEPQQ PVLKKDLETI IARDQDLQEL
860 870 880 890 900
IQGLVAPATR PPLTLKQRHK AFDNYLRLVY GSDLMDINPE RESQQWGTSA
910 920 930 940 950
LSTEKESSDQ ESQPGPVMIV GQAAFSNDVQ PVFPLSFPQP PGGAPGKRFA
960 970 980 990 1000
RPPRVSLPIP PTYRRVHSRA SQLLARSSLS CELGLGLDLQ VQWDQFAVKA
1010 1020 1030 1040 1050
IDLDASIDYM KNRVPLLLQR KPAEPLSKLM GFFPATIKPY RLRSRPIKFP
1060 1070 1080 1090 1100
GCVPNSVVLR QMWLQAEVSG LGSLAELSSQ SRTKAESEDE QWSRRRKHSS
1110 1120 1130 1140 1150
LRWRNKLFGL LRLTRRKGGE EEEEERRKEE EVFERDLIPS SQTSATEPEH
1160 1170 1180 1190 1200
WKPDTDSATD LISKLCNEAS KTKGYSQPLQ FGRSFLEERY GHLPKFLHYF
1210 1220 1230 1240 1250
VVQNWFKKLF PIFTLEAYPE MGTIEGLASM FLDFLLKASW ADRVNILNSL
1260 1270 1280 1290 1300
LRLLPDITGN LRIRLQAKLL YLLNQDDPPK LQDPTQKEFV MIALQLLLAC
1310 1320 1330 1340 1350
NLDVLEVVLE IISYYLYSPI SCRQELKKLL EGLGLHDPEG VLFKEIMTWV
1360 1370 1380 1390 1400
EDLKVESKAT IRIQCQQKLE DIYLQADTLE QSTVSIFVEP SRQVSQTSLI
1410 1420 1430 1440 1450
SGGSLPAMST SWTFSRASEM SLVPSPVEPI ESMEQVTSIV SIPELQMASS
1460 1470 1480 1490 1500
QAHMRIQKTK RVLADMLQTF GLEDSEYPFK FDVPRRESPL AQTLWARSQI
1510 1520 1530 1540 1550
VDLFHMDMLN LFCEKRRVQQ QRSSMGEEKE EEGKEEEEEE EEEEEEEEEE
1560 1570 1580 1590 1600
EEEEHLPVSL LRRHQLRPNA VLRPRRERWL YPILRLQEAK APDFGVFLRS
1610 1620 1630 1640 1650
HKMQSRELTT DGSLRVLKLP LPRVDLQPFP PGWPTPPRAL PPLLLQPSLQ
1660
RYFLLQDTYP GAFS
Length:1,664
Mass (Da):187,197
Last modified:June 20, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i400EE93A316591B7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AC155074 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_006521683.1, XM_006521620.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000208833; ENSMUSP00000146420; ENSMUSG00000109179

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
102638882

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC155074 Genomic DNA No translation available.
RefSeqiXP_006521683.1, XM_006521620.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

EPDiA0A140LHH9

Genome annotation databases

EnsembliENSMUST00000208833; ENSMUSP00000146420; ENSMUSG00000109179
GeneIDi102638882

Organism-specific databases

MGIiMGI:5594498 Gm35339

Phylogenomic databases

GeneTreeiENSGT00940000163397

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Gm35339 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits
SUPFAMiSSF48371 SSF48371, 1 hit
SSF50978 SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A140LHH9_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A140LHH9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 11, 2016
Last sequence update: June 20, 2018
Last modified: October 16, 2019
This is version 24 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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