UniProtKB - A0A140LGV2 (A0A140LGV2_DANRE)
Histone H4
si:ch73-368j24.1
Functioni
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
UniRule annotationARBA annotationGO - Molecular functioni
- DNA binding Source: GO_Central
- protein heterodimerization activity Source: InterPro
GO - Biological processi
- nucleosome assembly Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Histone H4UniRule annotation |
Gene namesi | Name:si:ch73-368j24.1Imported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-160113-131, si:ch73-368j24.1 |
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Other locations
- Chromosome ARBA annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Other locations
- nucleosome Source: UniProtKB-KW
Keywords - Cellular componenti
Chromosome, Nucleosome coreUniRule annotation, NucleusUniRule annotationARBA annotationInteractioni
Subunit structurei
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
UniRule annotationGO - Molecular functioni
- protein heterodimerization activity Source: InterPro
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 87 | CENP-T_CInterPro annotationAdd BLAST | 65 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00990000203553 |
OMAi | HGITKTA |
OrthoDBi | 1594208at2759 |
Family and domain databases
CDDi | cd00076, H4, 1 hit |
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR035425, CENP-T/H4_C IPR009072, Histone-fold IPR001951, Histone_H4 |
Pfami | View protein in Pfam PF15511, CENP-T_C, 1 hit |
PRINTSi | PR00623, HISTONEH4 |
SMARTi | View protein in SMART SM00417, H4, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MSGVGKRQRC RMVLRDNLHG ITKTAIRRLA RRGGVKRISG LIYGETRDVL
60 70 80 90
KVFLTNVIRD AVTYTEHAKR KTVTAIDVVY ALKRQGRTLY GFGG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU457819 Genomic DNA No translation available. |
RefSeqi | XP_017212445.1, XM_017356956.1 |
Genome annotation databases
Ensembli | ENSDART00000173419; ENSDARP00000142481; ENSDARG00000105471 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU457819 Genomic DNA No translation available. |
RefSeqi | XP_017212445.1, XM_017356956.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSDART00000173419; ENSDARP00000142481; ENSDARG00000105471 |
Organism-specific databases
ZFINi | ZDB-GENE-160113-131, si:ch73-368j24.1 |
Phylogenomic databases
GeneTreei | ENSGT00990000203553 |
OMAi | HGITKTA |
OrthoDBi | 1594208at2759 |
Family and domain databases
CDDi | cd00076, H4, 1 hit |
Gene3Di | 1.10.20.10, 1 hit |
InterProi | View protein in InterPro IPR035425, CENP-T/H4_C IPR009072, Histone-fold IPR001951, Histone_H4 |
Pfami | View protein in Pfam PF15511, CENP-T_C, 1 hit |
PRINTSi | PR00623, HISTONEH4 |
SMARTi | View protein in SMART SM00417, H4, 1 hit |
SUPFAMi | SSF47113, SSF47113, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | A0A140LGV2_DANRE | |
Accessioni | A0A140LGV2Primary (citable) accession number: A0A140LGV2 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 11, 2016 |
Last sequence update: | May 11, 2016 | |
Last modified: | January 19, 2022 | |
This is version 31 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |