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UniProtKB - A0A140G945 (CRYA2_HUMAN)

Entry version 39 (07 Apr 2021)
Sequence version 1 (11 May 2016)
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Protein

Alpha-crystallin A2 chain

Gene

CRYAA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1Susceptible to oxidation1
Sitei18Susceptible to oxidation1
Sitei34Susceptible to oxidation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi79Zinc 1Curated1
Metal bindingi100Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi107Zinc 1Curated1
Metal bindingi115Zinc 1Curated1
Sitei138Susceptible to oxidation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		A0A140G945

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-crystallin A2 chainCurated
Cleaved into the following 3 chains:
Alpha-crystallin A2(1-172)
Alpha-crystallin A2(1-168)
Alpha-crystallin A2(1-162)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRYAA2Imported
Synonyms:CRYAAImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:51901, CRYAA2

neXtProt; the human protein knowledge platform

More...neXtProti		NX_A0A140G945

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000160202.7
HostDB:ENSG00000276076.4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi123N → D: Impairs chaperone activity. 1 Publication1

Keywords - Diseasei

Cataract

Organism-specific databases

DisGeNET

More...DisGeNETi		102724652
1409

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		604219, phenotype

Open Targets

More...OpenTargetsi		ENSG00000160202

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004445071 – 173Alpha-crystallin A2 chainAdd BLAST173
ChainiPRO_00004445081 – 172Alpha-crystallin A2(1-172)By similarityAdd BLAST172
ChainiPRO_00004445091 – 168Alpha-crystallin A2(1-168)By similarityAdd BLAST168
ChainiPRO_00004445101 – 162Alpha-crystallin A2(1-162)By similarityAdd BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionine1 Publication1
Modified residuei6Deamidated glutamine; partial1 Publication1
Modified residuei45Phosphoserine1 Publication1
Modified residuei50Deamidated glutamine; partial1 Publication1
Modified residuei70N6-acetyllysine2 Publications1
Modified residuei90Deamidated glutamine; partial1 Publication1
Modified residuei99N6-acetyllysine1 Publication1
Modified residuei101Deamidated asparagine; partial4 Publications1
Modified residuei122Phosphoserine3 Publications1
Modified residuei123Deamidated asparagine; partial1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi131 ↔ 1422 Publications
Modified residuei147Deamidated glutamine; partial1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi162O-linked (GlcNAc) serineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated; contains N-acetylglucosamine side chains.
Deamidation of Asn-101 in lens occurs mostly during the first 30 years of age, followed by a small additional amount of deamidation (approximately 5%) during the next approximately 38 years, resulting in a maximum of approximately 50% deamidation during the lifetime of the individual.5 Publications
Phosphorylation on Ser-122 seems to be developmentally regulated. Absent in the first months of life, it appears during the first 12 years of human lifetime. The relative amount of phosphorylated form versus unphosphorylated form does not change over the lifetime of the individual.5 Publications
Acetylation at Lys-70 seems to increase chaperone activity.3 Publications
Undergoes age-dependent proteolytical cleavage at the C-terminus. Alpha-crystallin A(1-172) is the most predominant form produced most rapidly during the first 12 years of age and after this age is present in approximately 50% of the lens molecules.5 Publications

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		A0A140G945

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		20516

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		A0A140G945, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		A0A140G945

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000160202, Expressed in adult mammalian kidney and 35 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		A0A140G945, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heteropolymer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and higher homooligomers. Age-dependent C-terminal truncation affects oligomerization.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

A0A140G945
With#Exp.IntAct
ACBD4 - isoform 3 [Q8NC06-3]3EBI-25838900,EBI-12811089
ADD1 [P35611]3EBI-25838900,EBI-2809187
ARFGAP3 [Q9NP61]3EBI-25838900,EBI-2875816
BAG3 [O95817]3EBI-25838900,EBI-747185
BAHD1 [Q8TBE0]3EBI-25838900,EBI-742750
BAIAP2 - isoform 6 [Q9UQB8-6]3EBI-25838900,EBI-9092016
C11orf54 - isoform 3 [Q9H0W9-3]3EBI-25838900,EBI-12108466
CD209 - isoform 10 [Q9NNX6-10]3EBI-25838900,EBI-12300031
CDCA4 [Q9BXL8]3EBI-25838900,EBI-1773949
CDK8 - isoform 2 [P49336-2]3EBI-25838900,EBI-11039720
COL9A1 [P20849]3EBI-25838900,EBI-2528238
COX4I1 [Q86WV2]3EBI-25838900,EBI-10260134
CRYBB3 [P26998]3EBI-25838900,EBI-1965681
DUSP10 [Q9Y6W6]3EBI-25838900,EBI-3443946
EEF1AKNMT [Q8N6R0]3EBI-25838900,EBI-1053295
EGFL8 [Q99944]3EBI-25838900,EBI-3924130
EIF3E [P60228]3EBI-25838900,EBI-347740
EIF4B [P23588]3EBI-25838900,EBI-970310
ESRP1 [Q6NXG1]3EBI-25838900,EBI-10213520
ESRP1 - isoform 3 [Q6NXG1-3]3EBI-25838900,EBI-21567429
FAAP20 - isoform 4 [Q6NZ36-4]3EBI-25838900,EBI-12013806
FAM122C - isoform 2 [Q6P4D5-2]3EBI-25838900,EBI-9091052
FAM163A [Q96GL9]3EBI-25838900,EBI-11793142
GABPB1 - isoform 2 [Q06547-2]3EBI-25838900,EBI-618189
GATA1 - isoform 2 [P15976-2]3EBI-25838900,EBI-9090198
GFOD1 [Q9NXC2]3EBI-25838900,EBI-8799578
GRB10 - isoform 4 [Q13322-4]3EBI-25838900,EBI-12353035
HMG20B [Q9P0W2]3EBI-25838900,EBI-713401
HOXB1 [Q4VB01]3EBI-25838900,EBI-17494170
HSPB1 [P04792]3EBI-25838900,EBI-352682
HTRA2 [O43464]3EBI-25838900,EBI-517086
HTT [P42858]3EBI-25838900,EBI-466029
IL16 - isoform 2 [Q14005-2]3EBI-25838900,EBI-17178971
INCA1 [Q0VD86]3EBI-25838900,EBI-6509505
KIF1B - isoform 2 [O60333-2]3EBI-25838900,EBI-10975473
KLF3 [P57682]3EBI-25838900,EBI-8472267
KLHL20 [Q9Y2M5]3EBI-25838900,EBI-714379
KRT81 [Q14533]3EBI-25838900,EBI-739648
KRTAP19-5 [Q3LI72]3EBI-25838900,EBI-1048945
KRTAP19-7 [Q3SYF9]3EBI-25838900,EBI-10241353
KRTAP8-1 [Q8IUC2]3EBI-25838900,EBI-10261141
LARP4B [Q92615]3EBI-25838900,EBI-1052558
LASP1 - isoform 2 [Q14847-2]3EBI-25838900,EBI-9088686
LGALS9C [Q6DKI2]3EBI-25838900,EBI-9088829
LOXL4 [Q96JB6]3EBI-25838900,EBI-749562
MAP3K5 [Q99683]3EBI-25838900,EBI-476263
MAPK11 [Q15759]3EBI-25838900,EBI-298304
NEUROG1 [Q92886]3EBI-25838900,EBI-10279647
NOD1 [Q9Y239]3EBI-25838900,EBI-1051262
NUDC [Q9Y266]3EBI-25838900,EBI-357298
PANX2 [Q495U3]3EBI-25838900,EBI-17242559
POLR1C [O15160]3EBI-25838900,EBI-1055079
POLR2E [P19388]3EBI-25838900,EBI-395189
PPP1R21 - isoform 5 [Q6ZMI0-5]3EBI-25838900,EBI-25835994
PRAM1 [Q96QH2]3EBI-25838900,EBI-2860740
PRPH [P41219]3EBI-25838900,EBI-752074
PRPS1 [P60891]3EBI-25838900,EBI-749195
PSME3 [P61289]3EBI-25838900,EBI-355546
PTTG1IP [P53801]3EBI-25838900,EBI-3906138
RBFOX1 - isoform 5 [Q9NWB1-5]3EBI-25838900,EBI-12123390
RBM4 [Q9BWF3]3EBI-25838900,EBI-2856454
RFFL - isoform 3 [Q8WZ73-3]3EBI-25838900,EBI-25839575
RGR - isoform 3 [P47804-3]3EBI-25838900,EBI-25834767
RHOJ [Q9H4E5]3EBI-25838900,EBI-6285694
RNF34 [Q969K3]3EBI-25838900,EBI-2340642
RPSA [P08865]3EBI-25838900,EBI-354112
RXRG [P48443]3EBI-25838900,EBI-712405
RYBP [Q8N488]3EBI-25838900,EBI-752324
SCAPER - isoform 3 [Q9BY12-3]3EBI-25838900,EBI-25837959
SDCCAG8 - isoform 2 [Q86SQ7-2]3EBI-25838900,EBI-10696955
SEMA4G - isoform 3 [Q9NTN9-3]3EBI-25838900,EBI-9089805
SGSM1 - isoform 3 [Q2NKQ1-4]3EBI-25838900,EBI-10182463
SPATA46 [Q5T0L3]3EBI-25838900,EBI-750105
SPATS1 [Q496A3]3EBI-25838900,EBI-3923692
SPRY4 [Q9C004]3EBI-25838900,EBI-354861
SPSB1 [Q96BD6]3EBI-25838900,EBI-2659201
STX11 [O75558]3EBI-25838900,EBI-714135
SYNCRIP - isoform 4 [O60506-4]3EBI-25838900,EBI-11123832
TCAP [O15273]3EBI-25838900,EBI-954089
TCP10L [Q8TDR4]3EBI-25838900,EBI-3923210
TENT5B [Q96A09]3EBI-25838900,EBI-752030
TEX12 [Q9BXU0]3EBI-25838900,EBI-12090309
TIMM17B [O60830]3EBI-25838900,EBI-2372529
TMPRSS6 - isoform 3 [Q8IU80-2]3EBI-25838900,EBI-25839648
TMTC1 - isoform 4 [Q8IUR5-4]3EBI-25838900,EBI-9089156
TNIP3 [Q96KP6]3EBI-25838900,EBI-2509913
TSACC [Q96A04]3EBI-25838900,EBI-740411
TSPAN2 [O60636]3EBI-25838900,EBI-3914288
TUT7 - isoform 5 [Q5VYS8-5]3EBI-25838900,EBI-9088812
UBE2V1 [Q13404]3EBI-25838900,EBI-1050671
UNKL - isoform 5 [Q9H9P5-5]3EBI-25838900,EBI-12817837
UQCC1 [Q9NVA1]3EBI-25838900,EBI-11911675
WBP1L [Q9NX94]3EBI-25838900,EBI-10316321
WWOX - isoform 5 [Q9NZC7-5]3EBI-25838900,EBI-12040603
ZHX1-C8orf76 [Q96EF9]3EBI-25838900,EBI-25830993
ZNF296 [Q8WUU4]3EBI-25838900,EBI-8834821
ZNF444 - isoform 2 [Q8N0Y2-2]3EBI-25838900,EBI-12010736
Q7Z7833EBI-25838900,EBI-9088990

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		A0A140G945, 97 interactors

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		A0A140G945

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0A140G945

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini52 – 164sHSPPROSITE-ProRule annotationAdd BLAST113

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160159

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_095001_2_1_1

Identification of Orthologs from Complete Genome Data

More...OMAi		GERQDDH

Database of Orthologous Groups

More...OrthoDBi		1187096at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		A0A140G945

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.790, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002068, A-crystallin/Hsp20_dom
IPR001436, Alpha-crystallin/sHSP_animal
IPR012274, Alpha-crystallin_A
IPR003090, Alpha-crystallin_N
IPR008978, HSP20-like_chaperone

The PANTHER Classification System

More...PANTHERi		PTHR45640, PTHR45640, 1 hit
PTHR45640:SF14, PTHR45640:SF14, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00525, Crystallin, 1 hit
PF00011, HSP20, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF036514, Sm_HSP_B1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00299, ACRYSTALLIN

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49764, SSF49764, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01031, SHSP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: A0A140G945-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVTIQHPWF KRTLGPFYPS RLFDQFFGEG LFEYDLLPFL SSTISPYYRQ 
        60         70         80         90        100
SLFRTVLDSG ISEVRSDRDK FVIFLDVKHF SPEDLTVKVQ DDFVEIHGKH 
       110        120        130        140        150
NERQDDHGYI SREFHRRYRL PSNVDQSALS CSLSADGMLT FCGPKIQTGL 
       160        170 
DATHAERAIP VSREEKPTSA PSS
Length:173
Mass (Da):19,909
Last modified:May 11, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i81804A8439837D50
GO
Isoform 2 (identifier: A0A140G945-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: MDVTIQHPWF...RTVLDSGISE → MPVCPGDSHRPPKALPHLVCGRRGRQ

Show »
Length:136
Mass (Da):15,316
Checksum:i23F971F4BB43EC62
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A096LPJ9A0A096LPJ9_HUMAN
Alpha-crystallin A2 chain
CRYAA2
127Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 19950 Da. Determined by ESI. 1 Publication
Molecular mass is 19863 Da. Determined by ESI. 1 Publication
Molecular mass is 20029 Da. Determined by ESI. With 1 phosphate group.1 Publication
Molecular mass is 19951 Da. Determined by ESI. 1 Publication
Molecular mass is 19864 Da. Determined by ESI. 1 Publication
Molecular mass is 19947 Da. Determined by ESI. 1 Publication
Molecular mass is 19851 Da. Determined by ESI. 1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0596041 – 63MDVTI…SGISE → MPVCPGDSHRPPKALPHLVC GRRGRQ in isoform 2. Add BLAST63

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
KM220588 mRNA Translation: AMM63583.1
KM220589 mRNA Translation: AMM63584.1
KM220590 mRNA Translation: AMM63585.1
KM220591 mRNA Translation: AMM63586.1
KM220592 mRNA Translation: AMM63587.1
AP001631 Genomic DNA No translation available.
FP236240 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS82651.1 [A0A140G945-1]
CCDS82652.1 [A0A140G945-2]

NCBI Reference Sequences

More...RefSeqi		NP_000385.1, NM_000394.3 [A0A140G945-1]
NP_001300979.1, NM_001314050.2 [A0A140G945-1]
NP_001307648.1, NM_001320719.1 [A0A140G945-2]
XP_005261150.1, XM_005261093.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000619537; ENSP00000482816; ENSG00000276076 [A0A140G945-1]
ENST00000624932; ENSP00000485302; ENSG00000276076 [A0A140G945-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		102724652
1409

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:102724652
hsa:1409

UCSC genome browser

More...UCSCi		uc061ywn.1, human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KM220588 mRNA Translation: AMM63583.1
KM220589 mRNA Translation: AMM63584.1
KM220590 mRNA Translation: AMM63585.1
KM220591 mRNA Translation: AMM63586.1
KM220592 mRNA Translation: AMM63587.1
AP001631 Genomic DNA No translation available.
FP236240 Genomic DNA No translation available.
CCDSiCCDS82651.1 [A0A140G945-1]
CCDS82652.1 [A0A140G945-2]
RefSeqiNP_000385.1, NM_000394.3 [A0A140G945-1]
NP_001300979.1, NM_001314050.2 [A0A140G945-1]
NP_001307648.1, NM_001320719.1 [A0A140G945-2]
XP_005261150.1, XM_005261093.3

3D structure databases

SMRiA0A140G945
ModBaseiSearch...

Protein-protein interaction databases

IntActiA0A140G945, 97 interactors

Chemistry databases

BindingDBiA0A140G945

PTM databases

GlyGeniA0A140G945, 1 site
iPTMnetiA0A140G945

Proteomic databases

MassIVEiA0A140G945
ProteomicsDBi20516

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		78327, 2 antibodies

Genome annotation databases

EnsembliENST00000619537; ENSP00000482816; ENSG00000276076 [A0A140G945-1]
ENST00000624932; ENSP00000485302; ENSG00000276076 [A0A140G945-2]
GeneIDi102724652
1409
KEGGihsa:102724652
hsa:1409
UCSCiuc061ywn.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		102724652
1409
DisGeNETi102724652
1409

GeneCards: human genes, protein and diseases

More...GeneCardsi		CRYAA2
HGNCiHGNC:51901, CRYAA2
MIMi604219, phenotype
neXtProtiNX_A0A140G945
OpenTargetsiENSG00000160202
VEuPathDBiHostDB:ENSG00000160202.7
HostDB:ENSG00000276076.4

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000160159
HOGENOMiCLU_095001_2_1_1
OMAiGERQDDH
OrthoDBi1187096at2759
PhylomeDBiA0A140G945

Enzyme and pathway databases

PathwayCommonsiA0A140G945

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		102724652, 0 hits in 4 CRISPR screens
1409, 4 hits in 987 CRISPR screens

Protein Ontology

More...PROi		PR:A0A140G945

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000160202, Expressed in adult mammalian kidney and 35 other tissues
ExpressionAtlasiA0A140G945, baseline

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068, A-crystallin/Hsp20_dom
IPR001436, Alpha-crystallin/sHSP_animal
IPR012274, Alpha-crystallin_A
IPR003090, Alpha-crystallin_N
IPR008978, HSP20-like_chaperone
PANTHERiPTHR45640, PTHR45640, 1 hit
PTHR45640:SF14, PTHR45640:SF14, 1 hit
PfamiView protein in Pfam
PF00525, Crystallin, 1 hit
PF00011, HSP20, 1 hit
PIRSFiPIRSF036514, Sm_HSP_B1, 1 hit
PRINTSiPR00299, ACRYSTALLIN
SUPFAMiSSF49764, SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031, SHSP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRYA2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A140G945
Secondary accession number(s): E9PHE4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2018
Last sequence update: May 11, 2016
Last modified: April 7, 2021
This is version 39 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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