UniProtKB - A0A140G945 (CRYA2_HUMAN)
Alpha-crystallin A2 chain
CRYAA2
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 1 | Susceptible to oxidation | 1 | |
Sitei | 18 | Susceptible to oxidation | 1 | |
Sitei | 34 | Susceptible to oxidation | 1 | |
Metal bindingi | 79 | Zinc 1Curated | 1 | |
Metal bindingi | 100 | Zinc 2By similarity | 1 | |
Metal bindingi | 102 | Zinc 2By similarity | 1 | |
Metal bindingi | 107 | Zinc 1Curated | 1 | |
Metal bindingi | 115 | Zinc 1Curated | 1 | |
Sitei | 138 | Susceptible to oxidation | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
- structural constituent of eye lens Source: InterPro
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | A0A140G945 |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-crystallin A2 chainCuratedCleaved into the following 3 chains: |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:51901, CRYAA2 |
neXtProti | NX_A0A140G945 |
VEuPathDBi | HostDB:ENSG00000160202.7 HostDB:ENSG00000276076.4 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 123 | N → D: Impairs chaperone activity. 1 Publication | 1 |
Keywords - Diseasei
CataractOrganism-specific databases
DisGeNETi | 102724652 1409 |
MIMi | 604219, phenotype |
OpenTargetsi | ENSG00000160202 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000444507 | 1 – 173 | Alpha-crystallin A2 chainAdd BLAST | 173 | |
ChainiPRO_0000444508 | 1 – 172 | Alpha-crystallin A2(1-172)By similarityAdd BLAST | 172 | |
ChainiPRO_0000444509 | 1 – 168 | Alpha-crystallin A2(1-168)By similarityAdd BLAST | 168 | |
ChainiPRO_0000444510 | 1 – 162 | Alpha-crystallin A2(1-162)By similarityAdd BLAST | 162 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionine1 Publication | 1 | |
Modified residuei | 6 | Deamidated glutamine; partial1 Publication | 1 | |
Modified residuei | 45 | Phosphoserine1 Publication | 1 | |
Modified residuei | 50 | Deamidated glutamine; partial1 Publication | 1 | |
Modified residuei | 70 | N6-acetyllysine2 Publications | 1 | |
Modified residuei | 90 | Deamidated glutamine; partial1 Publication | 1 | |
Modified residuei | 99 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 101 | Deamidated asparagine; partial4 Publications | 1 | |
Modified residuei | 122 | Phosphoserine3 Publications | 1 | |
Modified residuei | 123 | Deamidated asparagine; partial1 Publication | 1 | |
Disulfide bondi | 131 ↔ 142 | 2 Publications | ||
Modified residuei | 147 | Deamidated glutamine; partial1 Publication | 1 | |
Glycosylationi | 162 | O-linked (GlcNAc) serineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | A0A140G945 |
ProteomicsDBi | 20516 |
PTM databases
GlyGeni | A0A140G945, 1 site |
iPTMneti | A0A140G945 |
Expressioni
Gene expression databases
Bgeei | ENSG00000160202, Expressed in adult mammalian kidney and 35 other tissues |
ExpressionAtlasi | A0A140G945, baseline |
Interactioni
Subunit structurei
Heteropolymer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens. Can also form homodimers and higher homooligomers. Age-dependent C-terminal truncation affects oligomerization.
3 PublicationsBinary interactionsi
A0A140G945
Protein-protein interaction databases
IntActi | A0A140G945, 97 interactors |
Chemistry databases
BindingDBi | A0A140G945 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 52 – 164 | sHSPPROSITE-ProRule annotationAdd BLAST | 113 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00940000160159 |
HOGENOMi | CLU_095001_2_1_1 |
OMAi | GERQDDH |
OrthoDBi | 1187096at2759 |
PhylomeDBi | A0A140G945 |
Family and domain databases
Gene3Di | 2.60.40.790, 1 hit |
InterProi | View protein in InterPro IPR002068, A-crystallin/Hsp20_dom IPR001436, Alpha-crystallin/sHSP_animal IPR012274, Alpha-crystallin_A IPR003090, Alpha-crystallin_N IPR008978, HSP20-like_chaperone |
PANTHERi | PTHR45640, PTHR45640, 1 hit PTHR45640:SF14, PTHR45640:SF14, 1 hit |
Pfami | View protein in Pfam PF00525, Crystallin, 1 hit PF00011, HSP20, 1 hit |
PIRSFi | PIRSF036514, Sm_HSP_B1, 1 hit |
PRINTSi | PR00299, ACRYSTALLIN |
SUPFAMi | SSF49764, SSF49764, 1 hit |
PROSITEi | View protein in PROSITE PS01031, SHSP, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDVTIQHPWF KRTLGPFYPS RLFDQFFGEG LFEYDLLPFL SSTISPYYRQ
60 70 80 90 100
SLFRTVLDSG ISEVRSDRDK FVIFLDVKHF SPEDLTVKVQ DDFVEIHGKH
110 120 130 140 150
NERQDDHGYI SREFHRRYRL PSNVDQSALS CSLSADGMLT FCGPKIQTGL
160 170
DATHAERAIP VSREEKPTSA PSS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A096LPJ9 | A0A096LPJ9_HUMAN | Alpha-crystallin A2 chain | CRYAA2 | 127 | Annotation score: |
Mass spectrometryi
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_059604 | 1 – 63 | MDVTI…SGISE → MPVCPGDSHRPPKALPHLVC GRRGRQ in isoform 2. Add BLAST | 63 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KM220588 mRNA Translation: AMM63583.1 KM220589 mRNA Translation: AMM63584.1 KM220590 mRNA Translation: AMM63585.1 KM220591 mRNA Translation: AMM63586.1 KM220592 mRNA Translation: AMM63587.1 AP001631 Genomic DNA No translation available. FP236240 Genomic DNA No translation available. |
CCDSi | CCDS82651.1 [A0A140G945-1] CCDS82652.1 [A0A140G945-2] |
RefSeqi | NP_000385.1, NM_000394.3 [A0A140G945-1] NP_001300979.1, NM_001314050.2 [A0A140G945-1] NP_001307648.1, NM_001320719.1 [A0A140G945-2] XP_005261150.1, XM_005261093.3 |
Genome annotation databases
Ensembli | ENST00000619537; ENSP00000482816; ENSG00000276076 [A0A140G945-1] ENST00000624932; ENSP00000485302; ENSG00000276076 [A0A140G945-2] |
GeneIDi | 102724652 1409 |
KEGGi | hsa:102724652 hsa:1409 |
UCSCi | uc061ywn.1, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | KM220588 mRNA Translation: AMM63583.1 KM220589 mRNA Translation: AMM63584.1 KM220590 mRNA Translation: AMM63585.1 KM220591 mRNA Translation: AMM63586.1 KM220592 mRNA Translation: AMM63587.1 AP001631 Genomic DNA No translation available. FP236240 Genomic DNA No translation available. |
CCDSi | CCDS82651.1 [A0A140G945-1] CCDS82652.1 [A0A140G945-2] |
RefSeqi | NP_000385.1, NM_000394.3 [A0A140G945-1] NP_001300979.1, NM_001314050.2 [A0A140G945-1] NP_001307648.1, NM_001320719.1 [A0A140G945-2] XP_005261150.1, XM_005261093.3 |
3D structure databases
SMRi | A0A140G945 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | A0A140G945, 97 interactors |
Chemistry databases
BindingDBi | A0A140G945 |
PTM databases
GlyGeni | A0A140G945, 1 site |
iPTMneti | A0A140G945 |
Proteomic databases
MassIVEi | A0A140G945 |
ProteomicsDBi | 20516 |
Protocols and materials databases
Antibodypediai | 78327, 2 antibodies |
Genome annotation databases
Ensembli | ENST00000619537; ENSP00000482816; ENSG00000276076 [A0A140G945-1] ENST00000624932; ENSP00000485302; ENSG00000276076 [A0A140G945-2] |
GeneIDi | 102724652 1409 |
KEGGi | hsa:102724652 hsa:1409 |
UCSCi | uc061ywn.1, human |
Organism-specific databases
CTDi | 102724652 1409 |
DisGeNETi | 102724652 1409 |
GeneCardsi | CRYAA2 |
HGNCi | HGNC:51901, CRYAA2 |
MIMi | 604219, phenotype |
neXtProti | NX_A0A140G945 |
OpenTargetsi | ENSG00000160202 |
VEuPathDBi | HostDB:ENSG00000160202.7 HostDB:ENSG00000276076.4 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000160159 |
HOGENOMi | CLU_095001_2_1_1 |
OMAi | GERQDDH |
OrthoDBi | 1187096at2759 |
PhylomeDBi | A0A140G945 |
Enzyme and pathway databases
PathwayCommonsi | A0A140G945 |
Miscellaneous databases
BioGRID-ORCSi | 102724652, 0 hits in 1 CRISPR screen 1409, 4 hits in 876 CRISPR screens |
PROi | PR:A0A140G945 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000160202, Expressed in adult mammalian kidney and 35 other tissues |
ExpressionAtlasi | A0A140G945, baseline |
Family and domain databases
Gene3Di | 2.60.40.790, 1 hit |
InterProi | View protein in InterPro IPR002068, A-crystallin/Hsp20_dom IPR001436, Alpha-crystallin/sHSP_animal IPR012274, Alpha-crystallin_A IPR003090, Alpha-crystallin_N IPR008978, HSP20-like_chaperone |
PANTHERi | PTHR45640, PTHR45640, 1 hit PTHR45640:SF14, PTHR45640:SF14, 1 hit |
Pfami | View protein in Pfam PF00525, Crystallin, 1 hit PF00011, HSP20, 1 hit |
PIRSFi | PIRSF036514, Sm_HSP_B1, 1 hit |
PRINTSi | PR00299, ACRYSTALLIN |
SUPFAMi | SSF49764, SSF49764, 1 hit |
PROSITEi | View protein in PROSITE PS01031, SHSP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CRYA2_HUMAN | |
Accessioni | A0A140G945Primary (citable) accession number: A0A140G945 Secondary accession number(s): E9PHE4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2018 |
Last sequence update: | May 11, 2016 | |
Last modified: | February 10, 2021 | |
This is version 38 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 21
Human chromosome 21: entries, gene names and cross-references to MIM