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Entry version 13 (11 Dec 2019)
Sequence version 1 (11 May 2016)
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Protein
Submitted name:

Uncharacterized protein

Gene

TcasGA2_TC031662

Organism
Tribolium castaneum (Red flour beetle)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:TcasGA2_TC031662Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTribolium castaneum (Red flour beetle)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7070 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaColeopteraPolyphagaCucujiformiaTenebrionidaeTenebrionidae incertae sedisTribolium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007266 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini69 – 335Reverse transcriptaseInterPro annotationAdd BLAST267
Domaini1076 – 1089CCHC-typeInterPro annotationAdd BLAST14
Domaini1098 – 1113CCHC-typeInterPro annotationAdd BLAST16
Domaini1475 – 1747Reverse transcriptaseInterPro annotationAdd BLAST273

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni507 – 549DisorderedSequence analysisAdd BLAST43

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili830 – 857Sequence analysisAdd BLAST28
Coiled coili929 – 949Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi524 – 549PolarSequence analysisAdd BLAST26

Keywords - Domaini

Coiled coilSequence analysis, Zinc-fingerPROSITE-ProRule annotation

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR000477 RT_dom
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14529 Exo_endo_phos_2, 1 hit
PF00078 RVT_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00343 ZnF_C2HC, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56219 SSF56219, 1 hit
SSF57756 SSF57756, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50878 RT_POL, 2 hits
PS50158 ZF_CCHC, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A139W9A6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDHHFILLE VPMASKRQGK SNTFTEEEVE NACKRIKSGR APGPDGLPPE
60 70 80 90 100
VVKMVIKNNI NYFRDLYNNL LTGNRFPDEW KSAKLILIEK PKKNHTDEIK
110 120 130 140 150
YRPICLINVL GKVYENLINL RLYEEVDAKG GFHKNQYGFR KGRTTMHAIE
160 170 180 190 200
KIIQIAKEAN VSKKFNALVL TDVRNAFNTA SWPIIVKKLK DIGVQEYLIN
210 220 230 240 250
LVKSYFNNRT IQVSNDNKKN IGGEVPQGSI LGPTLWNIMY NDVMNIETEE
260 270 280 290 300
DIQYIYYVDD LAISITAKDK EELMLKTNAT LSAANVWMTH NELKIAPEKT
310 320 330 340 350
EAIIFGCKKI TNINFTIDGT TVKPTSSVTY LGIKIDRRLN FNKHIDAACE
360 370 380 390 400
KAKCTIKALN AILPNVRGPK PNKRKILAMT MQSAILYGAP AWADATGTCG
410 420 430 440 450
NQKKLKTTQR IMALRTCSAY RTVSTDAAVV VAGLVPLHIL AGERQRLYNL
460 470 480 490 500
RRHERALPWD GPHLIARTRG IHMKKVFLKQ EKEAGKLAGE GTLRKDLSKT
510 520 530 540 550
DALKVAAGKQ TAKLDEAENP KTPGEDSSLG NINPFGRSSM TPRSPQRTVQ
560 570 580 590 600
TSLIVGQTPK LDETIEAYKE TPTGAIPKRK RVSTPEEAHK VKKLVETRIK
610 620 630 640 650
KQKSLVLGNT ICTDILQAFT QVTSRLAKKV KVLQDRIDDT PNTRREIKND
660 670 680 690 700
AKAVCYAMAD MQAMQDNVFE EIFKWQRHIQ MEDSDDDVVL VESLENKGVD
710 720 730 740 750
IQVTTQTKEV ITKNAETQTP IEMWGKSTQV TEMSQPGQLR EPLYIGDKRS
760 770 780 790 800
FVDFKDLSNR DWKESYFEKV KIKAVNPLAM MPEAAPTIIR TRDKKEEGAL
810 820 830 840 850
LKMLHQRCPE YRESVLEGED PIESKASGYL KETYEALEEL KEVLKELQIE
860 870 880 890 900
KVAIGSDITG REEHLRKMLE YIFRWENVEV TLCVPIAKEM IWRDQGKAQS
910 920 930 940 950
AISVSPKGMR KTDAVIVQGS KTETYEAVLK EVRESLAETD CEIRAVRKTR
960 970 980 990 1000
EGKLLLLVGK EGEQAKKVKE ALCSKMANRK IVLRDDSTKE DKVLHVKGLD
1010 1020 1030 1040 1050
ALAVETEIVS SVVAAMDGTI TNTDLEVTSL RKAYGGSKGA TIKVPAKTAE
1060 1070 1080 1090 1100
AILSKGKIKI GLVTCKITER VNSVFCYRCW EPGHMAARCQ GVDRSKLCHR
1110 1120 1130 1140 1150
CGEEGHSAKT CEKEMFCPVC GTDDAANDVA IAVMNKKIKV YAWGKGLGFV
1160 1170 1180 1190 1200
WIDTGECIIY SCYISPNVEP VIAERALRNL VGSIGSHGRK PCVVTNDFNA
1210 1220 1230 1240 1250
KSPEWGGETQ DERGSLLSEW LATLNCVVHN DGMKPTFLKG RYQSWIDITF
1260 1270 1280 1290 1300
STENAARPLV IRHSFVEKMN TKQNKDCVSM VEAIKEACDM HLPKKGRTRN
1310 1320 1330 1340 1350
TAKQRVYWWN DDIARARKEC ISVKRRQMRL RARNRLEEVI EVTELYKQKR
1360 1370 1380 1390 1400
KIYRVLIRKA KEAKWEELIN EIERDQWGLG YQIATRKLRL GSEQITLSPQ
1410 1420 1430 1440 1450
FRQRIADVLF PKHQIKRWNL TETCEVEGIT SNEMQQAVRK LKTGKVPGLD
1460 1470 1480 1490 1500
NIPVEIVKAI AHEQGEGLML EAYNGLLREG KFPKEWKRAK LVLLKKPGKE
1510 1520 1530 1540 1550
GGSPSDFRPI CLLNVVAKLY EQLILIKLKK ELEEKGGLSE EQFGFQEGKS
1560 1570 1580 1590 1600
TLDAVDRVMA LARWANSGDT RRKRWCVLLT FDVKNAFNSA NWQNIMEALR
1610 1620 1630 1640 1650
KKGISMYLRK VIGSYLSERS LDLGEGQVME VTSGVPQGSV LGPTLWNILY
1660 1670 1680 1690 1700
DGVLRLEIPK EATLVAYADD LALVVIEKDI ENLMCTVEMT SKIIGRWMKE
1710 1720 1730 1740 1750
NGLQLAPEKT EAVLLAGGRR PDKNIVFKVE NVELRPKQNV RYLGVDINQR
1760 1770 1780 1790 1800
MTFTSHVMRV AAKAEKMGAM LGRLMPNVKG PSPSKRKVMA EVVNSIVMYA
1810 1820 1830 1840 1850
APIWGPTALD MLKYQERLVQ VQRKTALRVC SAYRTVSADA VQVIAGMIPI
1860 1870 1880 1890 1900
DLRIHETVKV RNRTHTKREA REWSIKEWQN RWNASSKGRW THRLIPDIRQ
1910 1920 1930 1940 1950
WIERKKNAGQ VNFYLTQFLS GHGDFRCYLR KMHRAENDRC VYCGEMDTAE
1960 1970 1980 1990 2000
HVLFQCGKWA GIRHRLEQLV NEKINPDNLV EIMLRSNKNW RTVQRCTEDI
2010 2020
LKFKMEDEKT GQINSPRDSS EVLTSI
Length:2,026
Mass (Da):229,837
Last modified:May 11, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE8B7AFEEC242BBF1
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KQ972544 Genomic DNA Translation: KXZ75870.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
TC031662_001; TC031662_001; TC031662

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KQ972544 Genomic DNA Translation: KXZ75870.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblMetazoaiTC031662_001; TC031662_001; TC031662

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR000477 RT_dom
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PfamiView protein in Pfam
PF14529 Exo_endo_phos_2, 1 hit
PF00078 RVT_1, 2 hits
SMARTiView protein in SMART
SM00343 ZnF_C2HC, 3 hits
SUPFAMiSSF56219 SSF56219, 1 hit
SSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50878 RT_POL, 2 hits
PS50158 ZF_CCHC, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A139W9A6_TRICA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A139W9A6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 11, 2016
Last sequence update: May 11, 2016
Last modified: December 11, 2019
This is version 13 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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