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Entry version 19 (07 Apr 2021)
Sequence version 1 (11 May 2016)
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Protein

Endonuclease

Gene

TcasGA2_TC031725

Organism
Tribolium castaneum (Red flour beetle)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
EndonucleaseARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:TcasGA2_TC031725Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTribolium castaneum (Red flour beetle)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7070 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaColeopteraPolyphagaCucujiformiaTenebrionidaeTenebrionidae incertae sedisTribolium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007266 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini364 – 437Peptidase A2InterPro annotationAdd BLAST74
Domaini543 – 717Reverse transcriptaseInterPro annotationAdd BLAST175
Domaini987 – 1159Integrase catalyticInterPro annotationAdd BLAST173

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 48DisorderedSequence analysisAdd BLAST48
Regioni282 – 310DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi26 – 45PolyampholyteSequence analysisAdd BLAST20

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0017, Eukaryota

Identification of Orthologs from Complete Genome Data

More...
OMAi
CEICATF

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.70.10, 1 hit
3.30.420.10, 1 hit
3.30.70.270, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR001584, Integrase_cat-core
IPR041588, Integrase_H2C2
IPR001995, Peptidase_A2_cat
IPR021109, Peptidase_aspartic_dom_sf
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
IPR000477, RT_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF17921, Integrase_H2C2, 1 hit
PF00665, rve, 1 hit
PF00078, RVT_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50630, SSF50630, 1 hit
SSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50175, ASP_PROT_RETROV, 1 hit
PS50994, INTEGRASE, 1 hit
PS50878, RT_POL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A139W8U7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKFLVRTPI DLQKKMNSTD TETPIMAGKE RGENSENKTA DSQSDDVDMD
60 70 80 90 100
IDEEPETVQE ELVETTRIRE SIITNLVRRG NLYNDATQNP TIIDRVALKV
110 120 130 140 150
PPFWAEDPSL WFLQLEGQFQ LNRVTLDATK YFYVITNLET RYLMEIKDVI
160 170 180 190 200
TNIPETNNQE QKTRRLLERE EMGDRTPSQF LRHLRDLAGA NVHESFLRTL
210 220 230 240 250
WTGRLPRNMQ AILATQSKCT LDEVAVSADK IHETIPEARV FAINNNANAS
260 270 280 290 300
SATTGTHGNF DATISALSQQ VQDLSRQLAA LQTSQSGHAS RFGTRAPSRY
310 320 330 340 350
RSRSRSKPRD GKCWFHHRFG DKARKCEAPC SYQKKKRHKQ SVVAAYDCAR
360 370 380 390 400
NTCRLFIRNR DDGVPFLIDT SADVSVFPKK LLRGSPPASD VVLFAVNGTR
410 420 430 440 450
FPTYGLRTLQ LNLGLRRVFK WQFIIADVSY AIIGADFIHH YKLLVDLRNR
460 470 480 490 500
RLIDSLTQVC AECEIRAVDV PTVKTLCIAG ASEYHRLLLE FPAITKPPNI
510 520 530 540 550
HQERRHNTVH FIRTTDGPPV SCRPRRLAPD RYKAAKKEFD AMVRDGIARP
560 570 580 590 600
SDGNWSSPLH LVPKKDGNLR PCGDYRRLNA RTIPDRYPVP HIEDFSHALH
610 620 630 640 650
GKKVFSTIDL VRAYHQIPVN PQDVPKTAIT TPFGLFEYTQ LSFGLRNASQ
660 670 680 690 700
TFQRFIYEVT HELDFCFAYI DDVLVASENS QQHLRKLFTR FLDYGVVINS
710 720 730 740 750
DKCKFGQSEV TFLGYHISDK GTQPPTDRVQ AILDMKKPST LKELQRFLGM
760 770 780 790 800
VNFYRRFIPQ AARIQAPLTQ LQGGPKAKQK ETIKWCPETE NAFEATKRSL
810 820 830 840 850
ANAALLAHPS PEAPLSICMN QNPEKASPRQ FRYLDFISQF TTDIQHVSGA
860 870 880 890 900
SNIPADTLSR IETVSGVQIH FFKLPELAKA QEDDAELKHL FSSQNSCSLN
910 920 930 940 950
KLYFPEHACS IVCDTSTGTI RPYLPEAYRK QVFYNVHNLS HPGVNATTKM
960 970 980 990 1000
VKQKYMWPGI DKNCRTWARQ CISCQRSKIT RHTKSNFGSF PTPTNRFRHL
1010 1020 1030 1040 1050
HLDLVGPLPP SHGYKYVLTC IDRFTRWPEA IPIKDISAET VAQALLHTWI
1060 1070 1080 1090 1100
ARFGIPELIT TDRGTQFDSE LFRNMSKLFG ICHCKTTAYH PQANGMIERL
1110 1120 1130 1140 1150
HQQLKTSIKC HNTENWFDCL PLVLLGIRSA VKENIKSSAA EMVYGEPLSL
1160 1170 1180 1190
PGEFFHSPQE ELTSSVLDRL RRKVQDFVAV APQRHGLPKP SCHWS
Length:1,195
Mass (Da):136,152
Last modified:May 11, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB400870E636B24AC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
KQ972957 Genomic DNA Translation: KXZ75711.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
TC031725_001; TC031725_001; TC031725

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KQ972957 Genomic DNA Translation: KXZ75711.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblMetazoaiTC031725_001; TC031725_001; TC031725

Phylogenomic databases

eggNOGiKOG0017, Eukaryota
OMAiCEICATF

Family and domain databases

Gene3Di2.40.70.10, 1 hit
3.30.420.10, 1 hit
3.30.70.270, 3 hits
InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR001584, Integrase_cat-core
IPR041588, Integrase_H2C2
IPR001995, Peptidase_A2_cat
IPR021109, Peptidase_aspartic_dom_sf
IPR043128, Rev_trsase/Diguanyl_cyclase
IPR012337, RNaseH-like_sf
IPR036397, RNaseH_sf
IPR000477, RT_dom
PfamiView protein in Pfam
PF17921, Integrase_H2C2, 1 hit
PF00665, rve, 1 hit
PF00078, RVT_1, 1 hit
SUPFAMiSSF50630, SSF50630, 1 hit
SSF53098, SSF53098, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS50175, ASP_PROT_RETROV, 1 hit
PS50994, INTEGRASE, 1 hit
PS50878, RT_POL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A139W8U7_TRICA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A139W8U7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 11, 2016
Last sequence update: May 11, 2016
Last modified: April 7, 2021
This is version 19 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported, Transposable elementARBA annotation
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