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UniProtKB - A0A133LSV3 (A0A133LSV3_BIFLN)

Entry version 28 (07 Apr 2021)
Sequence version 1 (08 Jun 2016)
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Protein

Isoprenyl transferase

Gene

uppS

Organism
Bifidobacterium longum
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.UniRule annotation

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei43UniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi43MagnesiumUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei48SubstrateUniRule annotation1
Binding sitei56SubstrateUniRule annotation1
Binding sitei60SubstrateUniRule annotation1
Active sitei91Proton acceptorUniRule annotation1
Binding sitei92SubstrateUniRule annotation1
Binding sitei94SubstrateUniRule annotation1
Binding sitei211SubstrateUniRule annotation1
Metal bindingi230MagnesiumUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseUniRule annotationImportedARBA annotation
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Isoprenyl transferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:uppSImported
ORF Names:APC1462_1390Imported, APC1476_1468Imported, APC1503_1440Imported, B5779_0254Imported, B5780_0019Imported, Blongum51A_1247Imported, DPC6316_1326Imported, DPC6317_1347Imported, HMPREF3231_00456Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBifidobacterium longumImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri216816 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Actinobacteria › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000232654 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000192302 Componenti: Unassembled WGS sequence
  • UP000070323 Componenti: Unassembled WGS sequence
  • UP000297677 Componenti: Chromosome
  • UP000192607 Componenti: Unassembled WGS sequence
  • UP000232402 Componenti: Unassembled WGS sequence
  • UP000232439 Componenti: Unassembled WGS sequence
  • UP000232554 Componenti: Unassembled WGS sequence
  • UP000232637 Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		216816.GS08_07095

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		A0A133LSV3

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni44 – 47Substrate bindingUniRule annotation4
Regioni88 – 90Substrate bindingUniRule annotation3
Regioni217 – 219Substrate bindingUniRule annotation3

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0020, Bacteria

Family and domain databases

Conserved Domains Database

More...CDDi		cd00475, Cis_IPPS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.1180.10, 1 hit

HAMAP database of protein families

More...HAMAPi		MF_01139, ISPT, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001441, UPP_synth-like
IPR018520, UPP_synth-like_CS
IPR036424, UPP_synth-like_sf

The PANTHER Classification System

More...PANTHERi		PTHR10291, PTHR10291, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01255, Prenyltransf, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF64005, SSF64005, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00055, uppS, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01066, UPP_SYNTHASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A133LSV3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSMAFENVDY TSLDIPAAPF SDPARIPDFP KNKVPRHIGV IMDGNGRWAK 
        60         70         80         90        100
QRGMVRTNGH QAAEPVVFDT IAGAIEAGVR YLSLYTFSTE NWKRSPQEVR 
       110        120        130        140        150
FLMGFSREII HRRVEQMDEW GVRVRWSGRR PKLWKSVIDE LEAAEERTKN 
       160        170        180        190        200
NKVIDVVFCI NYGGRAEIAD ACAAIAREVR DGKISGDRVT EKMIADHLYN 
       210        220        230        240        250
PDIPDCDLVI RTSGEQRTSN FLPWEAAYAE LDFVPELFPD CGRDVLWRSI 
       260 
DHYIHRDRRF GGVK
Length:264
Mass (Da):30,244
Last modified:June 8, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAECEAC1C9E1366C7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
LRPQ01000021 Genomic DNA Translation: KWZ94879.1
NAQC01000001 Genomic DNA Translation: OQM61033.1
NAQL01000001 Genomic DNA Translation: OQM73146.1
PJDQ01000011 Genomic DNA Translation: PKC82114.1
PJDR01000012 Genomic DNA Translation: PKC84798.1
PJDT01000021 Genomic DNA Translation: PKC88112.1
PJDY01000016 Genomic DNA Translation: PKC99463.1
PJEF01000011 Genomic DNA Translation: PKD11324.1
CP026999 Genomic DNA Translation: QCH30840.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		KWZ94879; KWZ94879; HMPREF3231_00456
OQM61033; OQM61033; B5780_0019
OQM73146; OQM73146; B5779_0254
PKC82114; PKC82114; DPC6317_1347
PKC84798; PKC84798; DPC6316_1326
PKC88112; PKC88112; APC1503_1440
PKC99463; PKC99463; APC1476_1468
PKD11324; PKD11324; APC1462_1390
QCH30840; QCH30840; Blongum51A_1247

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|216816.115.peg.450

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LRPQ01000021 Genomic DNA Translation: KWZ94879.1
NAQC01000001 Genomic DNA Translation: OQM61033.1
NAQL01000001 Genomic DNA Translation: OQM73146.1
PJDQ01000011 Genomic DNA Translation: PKC82114.1
PJDR01000012 Genomic DNA Translation: PKC84798.1
PJDT01000021 Genomic DNA Translation: PKC88112.1
PJDY01000016 Genomic DNA Translation: PKC99463.1
PJEF01000011 Genomic DNA Translation: PKD11324.1
CP026999 Genomic DNA Translation: QCH30840.1

3D structure databases

SMRiA0A133LSV3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi216816.GS08_07095

Genome annotation databases

EnsemblBacteriaiKWZ94879; KWZ94879; HMPREF3231_00456
OQM61033; OQM61033; B5780_0019
OQM73146; OQM73146; B5779_0254
PKC82114; PKC82114; DPC6317_1347
PKC84798; PKC84798; DPC6316_1326
PKC88112; PKC88112; APC1503_1440
PKC99463; PKC99463; APC1476_1468
PKD11324; PKD11324; APC1462_1390
QCH30840; QCH30840; Blongum51A_1247
PATRICifig|216816.115.peg.450

Phylogenomic databases

eggNOGiCOG0020, Bacteria

Family and domain databases

CDDicd00475, Cis_IPPS, 1 hit
Gene3Di3.40.1180.10, 1 hit
HAMAPiMF_01139, ISPT, 1 hit
InterProiView protein in InterPro
IPR001441, UPP_synth-like
IPR018520, UPP_synth-like_CS
IPR036424, UPP_synth-like_sf
PANTHERiPTHR10291, PTHR10291, 1 hit
PfamiView protein in Pfam
PF01255, Prenyltransf, 1 hit
SUPFAMiSSF64005, SSF64005, 1 hit
TIGRFAMsiTIGR00055, uppS, 1 hit
PROSITEiView protein in PROSITE
PS01066, UPP_SYNTHASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A133LSV3_BIFLN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A133LSV3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 8, 2016
Last sequence update: June 8, 2016
Last modified: April 7, 2021
This is version 28 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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