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Protein

Metal transporter cnnm-3

Gene

cnnm-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable metal transporter. Probably acts redundantly with the other metal transport proteins cnnm-1, cnnm-2, cnnm-4 and cnnm-5 to regulate Mg2+ homeostasis. Promotes postembryonic gonad development by regulating Mg2+ levels, probably via AMPK signaling.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • determination of adult lifespan Source: UniProtKB
  • innate immune response Source: WormBase
  • magnesium ion homeostasis Source: UniProtKB
  • magnesium ion transport Source: UniProtKB
  • positive regulation of gonad development Source: UniProtKB
  • positive regulation of multicellular organism growth Source: UniProtKB
  • positive regulation of vulval development Source: UniProtKB
  • response to magnesium ion Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Metal transporter cnnm-3Curated
Alternative name(s):
CNNM family homolog 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cnnm-3Imported
ORF Names:C33D12.2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
C33D12.2a ; CE51453 ; WBGene00016343 ; cnnm-3
C33D12.2b ; CE04764 ; WBGene00016343 ; cnnm-3
C33D12.2c ; CE51420 ; WBGene00016343 ; cnnm-3
C33D12.2d ; CE51314 ; WBGene00016343 ; cnnm-3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 200ExtracellularCuratedAdd BLAST177
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei201 – 221HelicalSequence analysisAdd BLAST21
Topological domaini222 – 255CytoplasmicCuratedAdd BLAST34
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Topological domaini277 – 280ExtracellularCurated4
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Topological domaini302 – 322CytoplasmicCuratedAdd BLAST21
Transmembranei323 – 343HelicalSequence analysisAdd BLAST21
Topological domaini344 – 797ExtracellularCuratedAdd BLAST454

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype. Double knockout with cnnm-1 results in increased levels of intestinal Mg2+ and reduced levels in other tissues. This Mg2+ deficiency in tissues leads to a reduced lifespan, 100% sterility, and smaller animals that exhibit a developmental delay with defective gonad development and which therefore do not produce oocytes or form vulva. In addition, the gonad development defect in the cnnm-1 and cnnm-3 double knockout is rescued when the AMPK alpha subunit aak-2 is also knocked out. Double knockout with cnnm-2 results in 22% sterility. Quintuple knockout with cnnm-1, cnnm-2, cnnm-4 and cnnm-5 results in a reduced lifespan and 100% sterility.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500728369724 – 797Metal transporter cnnm-3CuratedAdd BLAST774

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi31N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi42N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi676N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi692N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi724N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi731N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi761N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
A0A131MCZ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the intestine and in neurons, but it is also expressed in a variety of tissues including the pharynx, hypodermis, rectum and in muscles.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00019737 Expressed in 4 organ(s), highest expression level in adult organism

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
A0A131MCZ8, 1 interactor

STRING: functional protein association networks

More...
STRINGi
6239.M02F4.3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
A0A131MCZ8

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini193 – 373CNNM transmembranePROSITE-ProRule annotationAdd BLAST181
Domaini393 – 454CBS 1PROSITE-ProRule annotationAdd BLAST62
Domaini461 – 527CBS 2PROSITE-ProRule annotationAdd BLAST67

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ACDP family.Curated

Keywords - Domaini

CBS domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2118 Eukaryota
COG1253 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169533

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000199577

KEGG Orthology (KO)

More...
KOi
K16302

Identification of Orthologs from Complete Genome Data

More...
OMAi
YNSSQIM

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0JHP

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000644 CBS_dom
IPR002550 CNNM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01595 DUF21, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51371 CBS, 2 hits
PS51846 CNNM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform aImported (identifier: A0A131MCZ8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKTPWALGL LIFLLTFTSP LSSSPVRSTD NSTSSKGLLN VNSSVILEPS
60 70 80 90 100
ILPSSASKPE SLHLSKVRVS GLRLEAHASS TENIVLGHNK KHNVVVVPNK
110 120 130 140 150
NVRVVLFGQN FQDIGALTFT ADGSCKDLAH FFEADFSSMT PIRVVVEMSF
160 170 180 190 200
PKTTESKDSF KLCVSEKFYA NPQFVIVEDP FTMVTTEIPP VDEYMPKWLS
210 220 230 240 250
WICLLILLCF SGLFSGLNLG LMTLSPYELQ LYIASGTEQE KRDAGRILPI
260 270 280 290 300
RKKGNQLLCT LLIGNVVVNV GVSLLMDQLV GSGFAVLVAA TSCIVVFGEI
310 320 330 340 350
IPQALCVKLG LPIGARTIPI TQVLLFLMYP LTWPISKVLD IFLKEELTRS
360 370 380 390 400
LERNKLVEML KLSEKSIIGG QSDEFKMVLG ALELYDKTVA HAMTRYEDIF
410 420 430 440 450
MLPHTLTLGA GMVTQILDMG YTRIPIYEND RKNIVALLFV KDLALLDPDD
460 470 480 490 500
NHNVMKIASI YNHEVRRVLV DMPLRNMLEE FKRGEYHMAL VERLVEQEDK
510 520 530 540 550
DPIYELCGLI TLEDIIEEII QCEIIDETDA VCDNVHRKKR QRKRNHDMSQ
560 570 580 590 600
IVNTAHAKCA INIQMLAVTI QVMSTCHKIF SSNYILPTIL EKLIRKNCKK
610 620 630 640 650
VETTQFSCLK EVGVVQPKPA VLFTKGEFSN KFIMILSGRA VVTIGKEEMR
660 670 680 690 700
LEAGAWHSFG TEVLDAMAEA IERSLNQSTS RSTVSLNTEI TNNSIGFIPD
710 720 730 740 750
FDTVILYECV FCEITAADLL LAYNSSQIMQ NNTKMQVVRS NSRISLIEEI
760 770 780 790
PKDAVSTPIR NGSVKLRTVS EGETVHLLPK NMECHFNKQE KYEEEEE
Length:797
Mass (Da):89,288
Last modified:May 11, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25AD3EA350EB4E85
GO
Isoform bImported (identifier: A0A131MCZ8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-547: Missing.

Show »
Length:250
Mass (Da):28,001
Checksum:i4957C3DDD62443FD
GO
Isoform cImported (identifier: A0A131MCZ8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     753-766: DAVSTPIRNGSVKL → KYLIGRWKRRGTYV
     767-797: Missing.

Show »
Length:766
Mass (Da):85,881
Checksum:i134B33359ADCF861
GO
Isoform dImported (identifier: A0A131MCZ8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-547: Missing.
     753-766: DAVSTPIRNGSVKL → KYLIGRWKRRGTYV
     767-797: Missing.

Show »
Length:219
Mass (Da):24,595
Checksum:iBA735514F6AAFC3F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0586621 – 547Missing in isoform b and isoform d. CuratedAdd BLAST547
Alternative sequenceiVSP_058663753 – 766DAVST…GSVKL → KYLIGRWKRRGTYV in isoform c and isoform d. CuratedAdd BLAST14
Alternative sequenceiVSP_058664767 – 797Missing in isoform c and isoform d. CuratedAdd BLAST31

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CCD66487.1
BX284606 Genomic DNA Translation: CZR14596.1
BX284606 Genomic DNA Translation: CZR14597.1
BX284606 Genomic DNA Translation: CZR14608.1

Protein sequence database of the Protein Information Resource

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PIRi
T16631

NCBI Reference Sequences

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RefSeqi
NP_001309670.1, NM_001322613.1 [A0A131MCZ8-1]
NP_001309671.1, NM_001322614.1 [A0A131MCZ8-3]
NP_001309682.1, NM_001322615.1 [A0A131MCZ8-4]
NP_508520.1, NM_076119.3 [A0A131MCZ8-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Cel.39134

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
C33D12.2a; C33D12.2a; WBGene00016343 [A0A131MCZ8-1]
C33D12.2b.1; C33D12.2b.1; WBGene00016343 [A0A131MCZ8-2]
C33D12.2b.2; C33D12.2b.2; WBGene00016343 [A0A131MCZ8-2]
C33D12.2c; C33D12.2c; WBGene00016343 [A0A131MCZ8-3]
C33D12.2d; C33D12.2d; WBGene00016343 [A0A131MCZ8-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
180591

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
cel:CELE_C33D12.2

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA Translation: CCD66487.1
BX284606 Genomic DNA Translation: CZR14596.1
BX284606 Genomic DNA Translation: CZR14597.1
BX284606 Genomic DNA Translation: CZR14608.1
PIRiT16631
RefSeqiNP_001309670.1, NM_001322613.1 [A0A131MCZ8-1]
NP_001309671.1, NM_001322614.1 [A0A131MCZ8-3]
NP_001309682.1, NM_001322615.1 [A0A131MCZ8-4]
NP_508520.1, NM_076119.3 [A0A131MCZ8-2]
UniGeneiCel.39134

3D structure databases

SMRiA0A131MCZ8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA0A131MCZ8, 1 interactor
STRINGi6239.M02F4.3

Proteomic databases

PaxDbiA0A131MCZ8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiC33D12.2a; C33D12.2a; WBGene00016343 [A0A131MCZ8-1]
C33D12.2b.1; C33D12.2b.1; WBGene00016343 [A0A131MCZ8-2]
C33D12.2b.2; C33D12.2b.2; WBGene00016343 [A0A131MCZ8-2]
C33D12.2c; C33D12.2c; WBGene00016343 [A0A131MCZ8-3]
C33D12.2d; C33D12.2d; WBGene00016343 [A0A131MCZ8-4]
GeneIDi180591
KEGGicel:CELE_C33D12.2

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
180591
WormBaseiC33D12.2a ; CE51453 ; WBGene00016343 ; cnnm-3
C33D12.2b ; CE04764 ; WBGene00016343 ; cnnm-3
C33D12.2c ; CE51420 ; WBGene00016343 ; cnnm-3
C33D12.2d ; CE51314 ; WBGene00016343 ; cnnm-3

Phylogenomic databases

eggNOGiKOG2118 Eukaryota
COG1253 LUCA
GeneTreeiENSGT00940000169533
HOGENOMiHOG000199577
KOiK16302
OMAiYNSSQIM
OrthoDBiEOG091G0JHP

Miscellaneous databases

Protein Ontology

More...
PROi
PR:A0A131MCZ8

Gene expression databases

BgeeiWBGene00019737 Expressed in 4 organ(s), highest expression level in adult organism

Family and domain databases

InterProiView protein in InterPro
IPR000644 CBS_dom
IPR002550 CNNM
PfamiView protein in Pfam
PF01595 DUF21, 1 hit
PROSITEiView protein in PROSITE
PS51371 CBS, 2 hits
PS51846 CNNM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNNM3_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A131MCZ8
Secondary accession number(s): A0A131MBV5, A0A131MD56, Q21469
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 30, 2016
Last sequence update: May 11, 2016
Last modified: December 5, 2018
This is version 22 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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