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Protein

GTP cyclohydrolase-2

Gene

ribA

Organism
Pasteurella multocida
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.UniRule annotation

Catalytic activityi

GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate.UniRule annotationSAAS annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: riboflavin biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-6-(D-ribitylamino)uracil from GTP.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. GTP cyclohydrolase-2 (ribA), GTP cyclohydrolase-2 (ribA)
  2. Riboflavin biosynthesis protein RibD (A6J89_001810), Riboflavin biosynthesis protein RibD (ribD), Riboflavin biosynthesis protein RibD (BGK37_06770), Riboflavin biosynthesis protein RibD (PmB_3g0066), Riboflavin biosynthesis protein RibD (A4210_08990)
  3. Riboflavin biosynthesis protein RibD (A6J89_001810), Riboflavin biosynthesis protein RibD (ribD), Riboflavin biosynthesis protein RibD (BGK37_06770), Riboflavin biosynthesis protein RibD (PmB_3g0066), Riboflavin biosynthesis protein RibD (A4210_08990)
  4. no protein annotated in this organism
This subpathway is part of the pathway riboflavin biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-6-(D-ribitylamino)uracil from GTP, the pathway riboflavin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi56Zinc; catalyticUniRule annotation1
Metal bindingi67Zinc; catalyticUniRule annotation1
Metal bindingi69Zinc; catalyticUniRule annotation1
Binding sitei72GTPUniRule annotation1
Binding sitei116GTPUniRule annotation1
Active sitei128Proton acceptorUniRule annotation1
Active sitei130NucleophileUniRule annotation1
Binding sitei151GTPUniRule annotation1
Binding sitei156GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi51 – 55GTPUniRule annotation5
Nucleotide bindingi94 – 96GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processRiboflavin biosynthesisUniRule annotationSAAS annotation
LigandGTP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00275; UER00400

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase-2UniRule annotation (EC:3.5.4.25UniRule annotation)
Alternative name(s):
GTP cyclohydrolase IIUniRule annotation
Gene namesi
Name:ribAUniRule annotationImported
OrganismiPasteurella multocidaImported
Taxonomic identifieri747 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 171GTP_cyclohydro2InterPro annotationAdd BLAST166

Sequence similaritiesi

Belongs to the GTP cyclohydrolase II family.UniRule annotation

Family and domain databases

CDDicd00641 GTP_cyclohydro2, 1 hit
Gene3Di3.40.50.10990, 1 hit
HAMAPiMF_00179 RibA, 1 hit
InterProiView protein in InterPro
IPR032677 GTP_cyclohydro_II
IPR000926 RibA
IPR036144 RibA-like_sf
PfamiView protein in Pfam
PF00925 GTP_cyclohydro2, 1 hit
SUPFAMiSSF142695 SSF142695, 1 hit
TIGRFAMsiTIGR00505 ribA, 1 hit

Sequencei

Sequence statusi: Complete.

A0A126QI51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKIQRVTEA NLPTEFGMFR IVGFEFPDTK KEHVALVLGE VENIDEPILA
60 70 80 90 100
RIHSECLTGD ALYSLKCDCG FQLAAALRQI SQEGRGVLIY HREEGRGIGL
110 120 130 140 150
INKIRAYSLQ DKGMDTIEAN LALGFAADER NFEVCADIFA LLGINKVRLL
160 170 180 190 200
TNNPNKIDTM KKAGINIVER VALNVGENRY NTEYLDTKAK KMGHFIIHNQ
210
QKYPLECPYC SEEVPVQEK
Length:219
Mass (Da):24,646
Last modified:May 11, 2016 - v1
Checksum:iACA41E998E323981
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KP660764 Genomic DNA Translation: AMK08603.1

Similar proteinsi

Entry informationi

Entry nameiA0A126QI51_PASMD
AccessioniPrimary (citable) accession number: A0A126QI51
Entry historyiIntegrated into UniProtKB/TrEMBL: May 11, 2016
Last sequence update: May 11, 2016
Last modified: April 25, 2018
This is version 10 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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