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Protein

2-phospho-L-lactate guanylyltransferase

Gene

cofC

Organism
Mycobacterium sp. IS-1496
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Guanylyltransferase that catalyzes the activation of 2-phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

(2S)-2-phospholactate + GTP = (2S)-lactyl-2-diphospho-5'-guanosine + diphosphate.UniRule annotation

Pathwayi: coenzyme F420 biosynthesis

This protein is involved in the pathway coenzyme F420 biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway coenzyme F420 biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationImported, Transferase
LigandGTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayi
UPA00071

Names & Taxonomyi

Protein namesi
Recommended name:
2-phospho-L-lactate guanylyltransferaseUniRule annotation (EC:2.7.7.68UniRule annotation)
Short name:
LP guanylyltransferaseUniRule annotation
Gene namesi
Name:cofCUniRule annotation
ORF Names:AU195_20495Imported
OrganismiMycobacterium sp. IS-1496Imported
Taxonomic identifieri1772284 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000053564 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the CofC family.UniRule annotation

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit

Sequencei

Sequence statusi: Complete.

A0A124ESY6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRGTTSNGAA ASDTDVAVVV AVKRLAAAKT RLAPIFAPGD RETVVLAMLV
60 70 80 90 100
DTVAAAAAVA SVTVVTPDPA AADAARALGA QVLDDPTPAG HPDPLNNALR
110 120 130 140 150
AAEAVVRTVT PNVVALQGDL PALRARELSE AIAAARARPR SFVGDRHGTG
160 170 180 190 200
TSALFAFGVP LDPRFGPDSA EQHRRSGAVE LTGSWPGLRY DIDTPDDLLA
210
ARRLGVGTQT ARAVGAQR
Length:218
Mass (Da):22,306
Last modified:April 13, 2016 - v1
Checksum:i691E8EACC15CF957
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LQIU01000034 Genomic DNA Translation: KUI28144.1
RefSeqiWP_059160292.1, NZ_LQIU01000034.1

Genome annotation databases

EnsemblBacteriaiKUI28144; KUI28144; AU195_20495

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LQIU01000034 Genomic DNA Translation: KUI28144.1
RefSeqiWP_059160292.1, NZ_LQIU01000034.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiKUI28144; KUI28144; AU195_20495

Enzyme and pathway databases

UniPathwayi
UPA00071

Family and domain databases

Gene3Di3.90.550.10, 1 hit
HAMAPiMF_02114 CofC, 1 hit
InterProiView protein in InterPro
IPR002835 Coenzyme_F420_CofC
IPR029044 Nucleotide-diphossugar_trans
PANTHERiPTHR40392 PTHR40392, 1 hit
PfamiView protein in Pfam
PF01983 CofC, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR03552 F420_cofC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A124ESY6_9MYCO
AccessioniPrimary (citable) accession number: A0A124ESY6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 13, 2016
Last sequence update: April 13, 2016
Last modified: December 20, 2017
This is version 8 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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