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Entry version 7 (12 Aug 2020)
Sequence version 1 (13 Apr 2016)
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Protein

Mitochondrial 3' processome subunit 2

Gene

MPSS2

Organism
Trypanosoma brucei brucei
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As part of the mitochondrial 3' processome (MPsome), involved in the maturation of guided RNA (gRNA) precursors.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • mitochondrial mRNA modification Source: UniProtKB

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mitochondrial 3' processome subunit 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MPSS21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiTrypanosoma brucei brucei
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaDiscobaEuglenozoaKinetoplasteaMetakinetoplastinaTrypanosomatidaTrypanosomatidaeTrypanosoma

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown at the procyclic stage causes moderate growth defect and reduces production of guided RNAs (gRNA) due to a block in the processing of gRNA precursors.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 27MitochondrionSequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000045068328 – 1642Mitochondrial 3' processome subunit 2Sequence analysisAdd BLAST1615

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at the procyclic stage (at protein level).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the mitochondrial 3' processome (MPsome) complex composed at least of terminal uridylyltransferase KRET1/TUT1, 3'-5' exonuclease DSS1, MPSS1, MPSS2 and MPSS3 (PubMed:26833087). Within the complex, interacts with DSS1 (PubMed:26833087).

1 Publication

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Transit peptide

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

A0A120KVR5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLPFLCHTR VCLFSNKIPF VLCGSRFAPA TLHAHHTAAG GGETLNFPEL
60 70 80 90 100
SSPSTSKEPS VGSDSPQKKN KKQAFDALAR WCGGHQQLLM RIQQSAEDTS
110 120 130 140 150
AGVVFETPLT EVDSAAIRWL QGSTEQLTCG QSLLVCSFVC EVLYCQLNSA
160 170 180 190 200
SGGIGVEEAQ RLQIHALTNR IAALLQRADE SNKLESQPLS VLMSCAYVVQ
210 220 230 240 250
RLKYVDNPLF GETQRSLVKV PPSIMFALLH KLRGDGLGKL FQLDERTATD
260 270 280 290 300
VCLSFLFIAT EEHRQAFFSS GDAALVSNVL RRLVRYTASK TRRMRIQKEG
310 320 330 340 350
DIIDLLTVDS PSDGGARQTP VCTSGTGFTS PSMRECAMIM QNVSFSSPSN
360 370 380 390 400
RLELLLYLLC VRRNLAQCSL KDIELVPTVL STVANIRSAE ACSIRKKIIS
410 420 430 440 450
QLWLPENNPT LVAQLLVHSG ESIPRYVTYL QGVPASKLSP RDAAQVILCA
460 470 480 490 500
GTYLSYESLQ LYIMAALRDI MPSSSLVTLG AETTSASVPA TASVPTRVPA
510 520 530 540 550
CDSLETVLSV LLMRVEEKGG SLSEVEKDAC MEYIRRLNEL IDWCASAPTS
560 570 580 590 600
SPKPALQRLT LLTKLFNRGL VVHAPETVVE LAVQSLQLDP GNTMMNTLKC
610 620 630 640 650
VSEALPLVSD DKKRSIIIEK MISYSGTRTT SSVIRFLLLL APLVDADSPH
660 670 680 690 700
SCELVEQLLK FHTLNPHKLR QASVEGVAKG IDVYTLLLIN GIDFLLASGD
710 720 730 740 750
WRSSPSQLQN VITTWVRDYT LYVMDPARKQ KIDDGAAAHV APATKGEKTD
760 770 780 790 800
VVQHQQPSRL NEGGELPTLS GPNDEELEQV FTCLLRAGVK LPHAFSSELL
810 820 830 840 850
SRIRRLQAKR NPADGTDQQV VFPLPAHFVF CCKLDVPVEV SVTPEMMKYH
860 870 880 890 900
IDACDYRIIH CVITAFFSAA GTFKHNINDL LLCNMRLASR SFELFIQRLG
910 920 930 940 950
EEASRSFRPA TVSSVVANTL RFVVNHITKQ ERCQRVLRKL NEKGGIEAGE
960 970 980 990 1000
EELEGDRSLI AEHTRLGELL TRMIAYLSGA HVKNVGLSVL DRLSLLSPAC
1010 1020 1030 1040 1050
GEYLMMRLST QLSEFTQVEL LYLVQKYPKS QDLVAELLGK SDLVSSMDFG
1060 1070 1080 1090 1100
DYMRVMRNLP MPINALVIGA HLPGLNFQWC TRILSSLSVR HESVPLHLLA
1110 1120 1130 1140 1150
SVLRRLNDVT ESATLTDRNI AFVVLQKYLQ FDQTSGDGGD LEERQRLIKC
1160 1170 1180 1190 1200
SCDKLLVLSR INSLDTLKEF LVEFPEALSG VICESLSKHV VQHIVGGLLK
1210 1220 1230 1240 1250
DLDGLLTLCR LLHRHKLLTS DVKVAIVDGF FMKTLQSEVE GRANIEGESS
1260 1270 1280 1290 1300
QGLQPLNSVR GASLKTTHPV SNVLALALLL SDGPLHFPGA SNSSSTICGD
1310 1320 1330 1340 1350
NERCAVSSMF QVVKESYTSP RDRLLIANTL VGQKGPNALT VVAKEICTEL
1360 1370 1380 1390 1400
IENCESVTSN DFSRLLQCIS RLKCWSELDL ANSRFDEVFQ RSCTQADAHS
1410 1420 1430 1440 1450
RCVAFRAVSF EADIFRRYES FMIPLLQETV DVMSNEDLET VLSSVLSLPF
1460 1470 1480 1490 1500
TEALESLIDA IGTRLLRMID QCRRSALIRL LQCHAAFGIQ DDALVSVCVA
1510 1520 1530 1540 1550
TLTDQCGRDF RLDTAQVLAL LQAAVDLDFF LPPKLVTSCF TWLEHHVENM
1560 1570 1580 1590 1600
TITQLGHAVR LAVDVEVGYT AAVHTLTLRA LEQRDAIRSN ASFREAVEML
1610 1620 1630 1640
CDEFSAEIPW HLRAPVLRRR YQSERLLEYL DKRRLAVDST VA
Length:1,642
Mass (Da):181,585
Last modified:April 13, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i84B20A7BEF57FAD3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
KT282121 Genomic DNA Translation: AME15291.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KT282121 Genomic DNA Translation: AME15291.1

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMPSS2_TRYBB
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A120KVR5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 12, 2020
Last sequence update: April 13, 2016
Last modified: August 12, 2020
This is version 7 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
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