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Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Burkholderia ubonensis
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotationSAAS annotation

Cofactori

K+UniRule annotationNote: Binds 2 potassium ions per subunit.UniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine from betaine aldehyde.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. NAD/NADP-dependent betaine aldehyde dehydrogenase (betB), NAD/NADP-dependent betaine aldehyde dehydrogenase (betB), NAD/NADP-dependent betaine aldehyde dehydrogenase (betB), NAD/NADP-dependent betaine aldehyde dehydrogenase (betB), NAD/NADP-dependent betaine aldehyde dehydrogenase (betB), NAD/NADP-dependent betaine aldehyde dehydrogenase (betB), NAD/NADP-dependent betaine aldehyde dehydrogenase (betB), NAD/NADP-dependent betaine aldehyde dehydrogenase (betB), NAD/NADP-dependent betaine aldehyde dehydrogenase (betB), NAD/NADP-dependent betaine aldehyde dehydrogenase (betB), NAD/NADP-dependent betaine aldehyde dehydrogenase (betB), NAD/NADP-dependent betaine aldehyde dehydrogenase (betB), NAD/NADP-dependent betaine aldehyde dehydrogenase (betB), NAD/NADP-dependent betaine aldehyde dehydrogenase (betB), NAD/NADP-dependent betaine aldehyde dehydrogenase (betB), NAD/NADP-dependent betaine aldehyde dehydrogenase (betB)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine from betaine aldehyde, the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Pathwayi: Carotenoid biosynthesis

This protein is involved in Carotenoid biosynthesis.SAAS annotation
View all proteins of this organism that are known to be involved in Carotenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi30Potassium 1UniRule annotation1
Metal bindingi97Potassium 1UniRule annotation1
Active sitei166Charge relay systemUniRule annotation1
Binding sitei213NAD/NADP; via amide nitrogenUniRule annotation1
Metal bindingi249Potassium 2; via carbonyl oxygenUniRule annotation1
Sitei251Seems to be a necessary countercharge to the potassium cationsUniRule annotation1
Active sitei255Proton acceptorUniRule annotation1
Binding sitei289NAD/NADPUniRule annotation1
Binding sitei390NAD/NADPUniRule annotation1
Metal bindingi460Potassium 2; via carbonyl oxygenUniRule annotation1
Metal bindingi463Potassium 2; via carbonyl oxygenUniRule annotation1
Active sitei467Charge relay systemUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi154 – 157NAD/NADPUniRule annotation4
Nucleotide bindingi180 – 183NAD/NADPUniRule annotation4
Nucleotide bindingi232 – 237NAD/NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotationSAAS annotation, NADUniRule annotationSAAS annotation, NADPUniRule annotation, PotassiumUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00529; UER00386

Names & Taxonomyi

Protein namesi
Recommended name:
NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betBUniRule annotation
ORF Names:WM15_19460Imported
OrganismiBurkholderia ubonensisImported
Taxonomic identifieri101571 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderiaBurkholderia cepacia complex
Proteomesi
  • UP000058930 Componenti: Unassembled WGS sequence

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei289Cysteine sulfenic acid (-SOH)UniRule annotation1

Keywords - PTMi

OxidationUniRule annotation

Interactioni

Subunit structurei

Dimer of dimers.UniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 482AldedhInterPro annotationAdd BLAST464

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili76 – 96Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 1 hit
HAMAPiMF_00804 BADH, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR011264 BADH
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR01804 BADH, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

A0A119UZF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVIGLPRGL QRLYIGGGYV DATSGKTFDT FDPATGELLA QVQQASAADV
60 70 80 90 100
DRAVASAREG QREWAAMTAM QRSRILRRAV ELLRERNDEL AALETRDTGK
110 120 130 140 150
PIAETLAVDI VTGADVIEYY AGLATAIEGL QVPLRAESFV YTRREPLGVC
160 170 180 190 200
AGIGAWNYPI QIACWKTAPA LAAGNAMVFK PSEVTPLTAL KLAEIYTEAG
210 220 230 240 250
VPAGVFNVVQ GDGSVGALLT GHPDIAKVSF TGGVETGKKV MSLAGASSLK
260 270 280 290 300
EVTMELGGKS PLIVFDDADL DRAADIAVTA NFFSSGQVCT NGTRVFVHRS
310 320 330 340 350
VKDAFTARVL ERVKRIRVGK PTDADTNFGP LVSAAQLDKV LGFIESGKAE
360 370 380 390 400
GAKLLAGGAR LTDGHFANGQ YVAPTVFGDC RDDMKIVREE IFGPVMSILE
410 420 430 440 450
FASEDEVIAR ANDTHFGLAA GVVTENLSRA HRTIHRLDAG ICWINTWGES
460 470 480 490
PAEMPVGGYK QSGVGRENGI TTLEHYTRIK SVQVELGRYN PVF
Length:493
Mass (Da):52,638
Last modified:April 13, 2016 - v1
Checksum:iB6E8BF3B66BC6A8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LPLS01000005 Genomic DNA Translation: KWK83467.1
RefSeqiWP_060286472.1, NZ_LPLS01000005.1

Genome annotation databases

EnsemblBacteriaiKWK83467; KWK83467; WM15_19460

Similar proteinsi

Entry informationi

Entry nameiA0A119UZF4_9BURK
AccessioniPrimary (citable) accession number: A0A119UZF4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 13, 2016
Last sequence update: April 13, 2016
Last modified: April 25, 2018
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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