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Entry version 27 (19 Jan 2022)
Sequence version 1 (13 Apr 2016)
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Protein
Submitted name:

Non-ribosomal peptide synthetase

Gene

AUL54_01365

Organism
Bacillus sp. SDLI1
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntibiotic biosynthesisARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Non-ribosomal peptide synthetaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AUL54_01365Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus sp. SDLI1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1774743 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000061465 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1005O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2033O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotationARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini970 – 1045CarrierInterPro annotationAdd BLAST76
Domaini1998 – 2072CarrierInterPro annotationAdd BLAST75

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili2166 – 2186Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
572620at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 1 hit
3.30.300.30, 2 hits
3.30.559.10, 3 hits
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR029058, AB_hydrolase
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR010060, NRPS_synth
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 2 hits
PF13193, AMP-binding_C, 2 hits
PF00668, Condensation, 3 hits
PF00550, PP-binding, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 2 hits
TIGR01720, NRPS-para261, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 2 hits
PS50075, CARRIER, 2 hits
PS00012, PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

A0A109WE69-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQQPEIQDI YPLSFMQEGM LFHSLLDHDS RAYFEQAVFT ISGQLDRERF
60 70 80 90 100
QKSIDAVFER YDIFRTTFIH KNVAKPRQVV LKNRPSRVQF HDISHLDEKA
110 120 130 140 150
QDMYADRFGK EDKDKGFDLQ SDPLMRVSIL KKAPERYVCI WSHHHIVMDG
160 170 180 190 200
WCFGIVMKEF LMIYQSLGDG RLPSLEPVQP YGKYIKWLMK QDRKEAESFW
210 220 230 240 250
KTRLADLEQT ASLPKKSAEP NGELEQAVFT ISEEQTNELK NIAARAGATL
260 270 280 290 300
NTVFQALWGI LLQRVSRCED AVFGSVVSGR PSDLAGVEKM VGLFINTIPV
310 320 330 340 350
RVKSGSFSFL ELVRHLQQET LQAEAYSYYP LYDIQAQSPL KQALFDHIIV
360 370 380 390 400
FENVPAQREI ENVSQAGSFD FAVEDFTMEE VTNYGCSVKV IPGSSLYIRL
410 420 430 440 450
NFDTGIYDRV FMKKIETFLR HMMKSVISDP EMSASEIALL DACEARNMLD
460 470 480 490 500
AFNRTEAAEP PAPTLHGLFT RRAALSPHRP ALRFPDGMLT YAELDRYTDR
510 520 530 540 550
LAVRLRQKGV RKESKVGVLA ERSPEMVISV LAVLKAGGAY VPLDPEYPED
560 570 580 590 600
RLRYMLKDSG ACLLLQQSGL SVPGFSGETL EVSLSALTGE TETGAVSEEA
610 620 630 640 650
DADSLAYIIY TSGSTGTPKG VAVEHRQAAA FLSGMQGQFP LTEEDIIVLK
660 670 680 690 700
SSFSFDASIW QLFWWTMSGA SVYLLPAGWE KDPARMIEAF ASEKVTTAHF
710 720 730 740 750
IPAMVNSFLD ALETEPEETR IRLGKTLTRV FAGGEALSPL TAARFADLLP
760 770 780 790 800
ETVLIHGYGP TEATVDAAFY VCDRKRDSGR TRLPIGKPVP GARLYVLDGG
810 820 830 840 850
GTVQPAGVAG ELYIAGTGVA RGYLNRPELT AERFLDDPFY PGERMYQTGD
860 870 880 890 900
IARWTEDGLV EWLGRSDGQV KVRGYRIEPG EIEAAIRRID GIREAAVTAR
910 920 930 940 950
TEHGETALYA YIEGRESDDV RAELAKRLPA YMMPAQFIEM SEWPVTPSGK
960 970 980 990 1000
LDRRALPAPD GAAGRQAYTA PRNVTEMKLC ALWEEVLKNG PVGIRDHFFE
1010 1020 1030 1040 1050
RGGHSLKATA LVSRIAKEFG VQVPLQDIFA RPTVEELAKV IQDLEESPYE
1060 1070 1080 1090 1100
AIQPAKTQDT YPVSSAQKRM YVLQQLEDGG VGYNMPAVLE LTGPLDRGRL
1110 1120 1130 1140 1150
EETFRQLVER HESLRTSFET GPDGEPVQRI HDSVPIQLDE AESADAFVRP
1160 1170 1180 1190 1200
FCLEEGPLFR AALVKESDER HLLLTDMHHI ISDGVSVNTL IKEFGELYAG
1210 1220 1230 1240 1250
RPLAPMRLQY KDYAVWQRSF QEKEGYQKQE AYWLKRLEGE LPVLELPADK
1260 1270 1280 1290 1300
PRPAVRSFAG GNVSCTLDAE TASGLHRIAR DHGSTLYMVL LAAYNTLLAR
1310 1320 1330 1340 1350
LSGQEDIIVG SPIAGRPHKD LEPILGMFVN TLAIRTEPKG DKRFTDYLAE
1360 1370 1380 1390 1400
VRQAALEAYE HQDYPFEELV ERLGVQRDTS RNPLFDVMFV LQNMERESLV
1410 1420 1430 1440 1450
LNELHLTQAA DTGHKTAKFD ATLYAAEGSD GTISFDFEFN ADIYQKQTIE
1460 1470 1480 1490 1500
KWLSYFTRIL TKVIEDQTIP LGDIHVLDDA ETNRVIYQFN QTKSDYPKHE
1510 1520 1530 1540 1550
TISRLFERQA EETPDAQAVV YRGQTLTYRE LNERANRIAA ALRSNGAGPE
1560 1570 1580 1590 1600
SVVALLTGRT TELVSGILGI LKAGGAYLPI ADDVPRERAE WMLKDCKADI
1610 1620 1630 1640 1650
LLQSDKVDGL PLSGKRLFIE DIQTKAGLSS ENPEPLGGPE SLAYMIYTSG
1660 1670 1680 1690 1700
STGAPKGVMV EQRSVIRLVK NSNYIDFTPK DRLLFTSSLG FDVTTFEIFG
1710 1720 1730 1740 1750
PLLNGASLYV SDQETYLDSD VLDAFIQQNG ITTLWLTSSL FNHLSEQNEH
1760 1770 1780 1790 1800
VFSGLSRLII GGEALSPSHV NRVRGALPHL AVWNGYGPTE NTTFSTCFLI
1810 1820 1830 1840 1850
EQSYDHSIPI GRPVGNSTAY IINGRGTPQP IGVIGELCTG GDGVARGYFG
1860 1870 1880 1890 1900
RPELTEEKFV PNPFVPGERM YRTGDLARWL PDGTIEYAGR MDDQVKIRGY
1910 1920 1930 1940 1950
RVELGEIEAA LRSLDGVKEA AVSVRTGQSG NKELIAYMSL QADMNIETVR
1960 1970 1980 1990 2000
SLLSQRLPNY MVPSYMMELE RLPLTPNGKL DRKNLPEPEL ALQTVYTAPR
2010 2020 2030 2040 2050
TELEEQLSVI WQEVLGAKQV GIEDSFFELG GDSIKALQVS ARLGRYGWKM
2060 2070 2080 2090 2100
AASDLFRHPT IKELAPLIRK AERVIDQRPV EGDIPWTPVQ HWFLSQRMEN
2110 2120 2130 2140 2150
RNHFNQSVMM FSSDALRKQP LKEALQHLVI HHDALRITAS AENGSHRQIN
2160 2170 2180 2190 2200
HGIQKDELYS LDIWDLSETD SREREIETEV AALQQRMDIE KGPLLKAGWF
2210 2220 2230 2240 2250
KTRSGDYLFI TIHHLAVDGV SWRILLEDLS AAYTQAVKGQ PVQLPPKTDS
2260 2270 2280 2290 2300
FKQYAERLSE YAKSSKLMRE EDDWRFIEEE TAAALPYEKP LHQTGADSIR
2310 2320 2330 2340 2350
QTVSFTLSEE ETSVLLQQVN RAYHTDTQDI LLTAAALALR DWTGGRLRIA
2360 2370 2380 2390 2400
MEGHGREHIM PELDISRTVG WFTSMYPVLI DLNTAGSELG TAVKTVKDTL
2410 2420 2430 2440 2450
GRIPDKGIGY GILKYMTPPE QKTIRFGQAP EISFNYLGQF NDTEDQHTFS
2460 2470 2480 2490 2500
LSGLASGHDI TPTWQREQAV EMSAMAAQHK LHFSLSYPPS RFRKETMEQL
2510 2520 2530 2540
LQTLQQYLRG IMAHCTGKEE SEKTVSDFSS KTLTSDDLDS IASFVEEL
Length:2,548
Mass (Da):285,622
Last modified:April 13, 2016 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDD6388B2C7FA7427
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CP013950 Genomic DNA Translation: AME05064.1

NCBI Reference Sequences

More...
RefSeqi
WP_060962641.1, NZ_CP013950.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AME05064; AME05064; AUL54_01365

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bacs:AUL54_01365

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP013950 Genomic DNA Translation: AME05064.1
RefSeqiWP_060962641.1, NZ_CP013950.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiAME05064; AME05064; AUL54_01365
KEGGibacs:AUL54_01365

Phylogenomic databases

OrthoDBi572620at2

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.30.300.30, 2 hits
3.30.559.10, 3 hits
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR029058, AB_hydrolase
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR010060, NRPS_synth
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 2 hits
PF13193, AMP-binding_C, 2 hits
PF00668, Condensation, 3 hits
PF00550, PP-binding, 2 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 2 hits
SUPFAMiSSF47336, SSF47336, 2 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 2 hits
TIGR01720, NRPS-para261, 1 hit
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 2 hits
PS50075, CARRIER, 2 hits
PS00012, PHOSPHOPANTETHEINE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiA0A109WE69_9BACI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: A0A109WE69
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: April 13, 2016
Last sequence update: April 13, 2016
Last modified: January 19, 2022
This is version 27 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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