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Protein

Ceramide very long chain fatty acid hydroxylase

Gene

AW171_hschr42197

Organism
Eremothecium sinecaudum
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ceramide hydroxylase involved in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids. Hydroxylates the very long chain fatty acid of ceramides at C2 and C3.UniRule annotation

Cofactori

Fe cationUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processFatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandIronUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide very long chain fatty acid hydroxylaseUniRule annotation (EC:1.-.-.-UniRule annotation)
Gene namesi
ORF Names:AW171_hschr42197Imported
OrganismiEremothecium sinecaudumImported
Taxonomic identifieri45286 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeEremothecium
Proteomesi
  • UP000243052 Componenti: Chromosome iv

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei191 – 208HelicalSequence analysisAdd BLAST18
Transmembranei215 – 233HelicalSequence analysisAdd BLAST19
Transmembranei253 – 269HelicalSequence analysisAdd BLAST17
Transmembranei276 – 294HelicalSequence analysisAdd BLAST19
Transmembranei300 – 324HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 89Cytochrome b5 heme-bindingInterPro annotationAdd BLAST82

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili88 – 108Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the sterol desaturase family. SCS7 subfamily.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR006694 Fatty_acid_hydroxylase
IPR014430 Scs7
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
PF04116 FA_hydroxylase, 1 hit
PIRSFiPIRSF005149 IPC-B_HD, 1 hit
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
PROSITEiView protein in PROSITE
PS50255 CYTOCHROME_B5_2, 1 hit

Sequencei

Sequence statusi: Complete.

A0A109UYS7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEESKTLPL YPKALLQQHN SKNDCWVSVN YRKIYDATDF IRQNPSMSQA
60 70 80 90 100
ILEYAGKDIA QALKDKVFNK QTTAAYEILK DSNLVGYLAT EEEERKLLTN
110 120 130 140 150
EKHTVEVKLC DSDLTKFVKV LPSEEKLLVR TDFRNDLQKH KFLDLNKPLL
160 170 180 190 200
KQLWNSNFTR EFYIDQIHRP RHYGRGSAVL FGNFLEPLSK TAWWVVPMLW
210 220 230 240 250
YPLVFYFLAK AAKNLSAPLV IALFIFGIFV WTLVEYSLHR FLFHVDNHLP
260 270 280 290 300
ESTVVFTLHF LLHGFHHYLP MDKYRLVLPP ALFIVLCTPI YKLVFLMFPY
310 320 330 340 350
YWACAGFAGG VFGYIGYDMT HYFLHHHKLP PFMRKLKKYH LEHHYKNYEL
360 370
GYGVTSWFWD KVFGTYLGSD APVAKMKYQ
Length:379
Mass (Da):44,653
Last modified:April 13, 2016 - v1
Checksum:i4EDB4AEB2E9E0323
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP014244 Genomic DNA Translation: AMD20310.1
RefSeqiXP_017987306.1, XM_018132116.1

Genome annotation databases

EnsemblFungiiAMD20310; AMD20310; AW171_hschr42197
GeneIDi28723551

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP014244 Genomic DNA Translation: AMD20310.1
RefSeqiXP_017987306.1, XM_018132116.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiAMD20310; AMD20310; AW171_hschr42197
GeneIDi28723551

Family and domain databases

Gene3Di3.10.120.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR006694 Fatty_acid_hydroxylase
IPR014430 Scs7
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
PF04116 FA_hydroxylase, 1 hit
PIRSFiPIRSF005149 IPC-B_HD, 1 hit
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
PROSITEiView protein in PROSITE
PS50255 CYTOCHROME_B5_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiA0A109UYS7_9SACH
AccessioniPrimary (citable) accession number: A0A109UYS7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 13, 2016
Last sequence update: April 13, 2016
Last modified: July 18, 2018
This is version 17 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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