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Protein

S-methyl-5'-thioadenosine phosphorylase

Gene

mtnP

Organism
Mycobacterium microti
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

S-methyl-5'-thioadenosine + phosphate = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: L-methionine biosynthesis via salvage pathway

This protein is involved in step 1 of the subpathway that synthesizes S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. S-methyl-5'-thioadenosine phosphorylase (mtnP)
This subpathway is part of the pathway L-methionine biosynthesis via salvage pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route), the pathway L-methionine biosynthesis via salvage pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei14PhosphateUniRule annotation1
Sitei162Important for substrate specificityUniRule annotation1
Binding sitei180Substrate; via amide nitrogenUniRule annotation1
Binding sitei181PhosphateUniRule annotation1
Sitei217Important for substrate specificityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase
Biological processPurine salvageUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00904; UER00873

Names & Taxonomyi

Protein namesi
Recommended name:
S-methyl-5'-thioadenosine phosphorylaseUniRule annotation (EC:2.4.2.28UniRule annotation)
Alternative name(s):
5'-methylthioadenosine phosphorylaseUniRule annotation
Short name:
MTA phosphorylaseUniRule annotation
Short name:
MTAPUniRule annotation
Gene namesi
Name:mtnPUniRule annotation
ORF Names:RN08_0598Imported
OrganismiMycobacterium microtiImported
Taxonomic identifieri1806 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
Proteomesi
  • UP000065169 Componenti: Chromosome

Interactioni

Subunit structurei

Homohexamer. Dimer of a homotrimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA0A109SKN4
SMRiA0A109SKN4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 239PNP_UDP_1InterPro annotationAdd BLAST231

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni55 – 56Phosphate bindingUniRule annotation2
Regioni204 – 206Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.UniRule annotation

Phylogenomic databases

KOiK00772

Family and domain databases

HAMAPiMF_01963 MTAP, 1 hit
InterProiView protein in InterPro
IPR010044 MTAP
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
PANTHERiPTHR42679 PTHR42679, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01694 MTAP, 1 hit

Sequencei

Sequence statusi: Complete.

A0A109SKN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHNNGRMLGV IGGSGFYTFF GSDTRTVNSD TPYGQPSAPI TIGTIGVHDV
60 70 80 90 100
AFLPRHGAHH QYSAHAVPYR ANMWALRALG VRRVFGPCAV GSLDPELEPG
110 120 130 140 150
AVVVPDQLVD RTSGRADTYF DFGGVHAAFA DPYCPTLRAA VTGLPGVVDG
160 170 180 190 200
GTMVVIQGPR FSTRAESQWF AAAGCNLVNM TGYPEAVLAR ELELCYAAIA
210 220 230 240 250
LVTDVDAGVA AGDGVKAADV FAAFGENIEL LKRLVRAAID RVADERTCTH
260
CQHHAGVPLP FELP
Length:264
Mass (Da):27,964
Last modified:April 13, 2016 - v1
Checksum:i3A850EA1B1873662
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP010333 Genomic DNA Translation: AMC58025.1

Genome annotation databases

EnsemblBacteriaiAMC58025; AMC58025; RN08_0598
KEGGimmic:RN08_0598
PATRICifig|1806.5.peg.628

Similar proteinsi

Entry informationi

Entry nameiA0A109SKN4_9MYCO
AccessioniPrimary (citable) accession number: A0A109SKN4
Entry historyiIntegrated into UniProtKB/TrEMBL: April 13, 2016
Last sequence update: April 13, 2016
Last modified: October 25, 2017
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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