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Protein

Kynureninase

Gene

kynU

Organism
Streptomyces corchorusii (Streptomyces chibaensis)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine.UniRule annotation
L-kynurenine + H2O = anthranilate + L-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi: L-kynurenine degradation

This protein is involved in step 1 of the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Kynureninase (kynU)
This subpathway is part of the pathway L-kynurenine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-alanine and anthranilate from L-kynurenine, the pathway L-kynurenine degradation and in Amino-acid degradation.

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes quinolinate from L-kynurenine.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Kynureninase (kynU)
  3. no protein annotated in this organism
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes quinolinate from L-kynurenine, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106Pyridoxal phosphate; via amide nitrogenUniRule annotation1
Binding sitei107Pyridoxal phosphateUniRule annotation1
Binding sitei204Pyridoxal phosphateUniRule annotation1
Binding sitei207Pyridoxal phosphateUniRule annotation1
Binding sitei229Pyridoxal phosphateUniRule annotation1
Binding sitei259Pyridoxal phosphateUniRule annotation1
Binding sitei285Pyridoxal phosphateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processPyridine nucleotide biosynthesisUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00253; UER00329
UPA00334; UER00455

Names & Taxonomyi

Protein namesi
Recommended name:
KynureninaseUniRule annotation (EC:3.7.1.3UniRule annotation)
Alternative name(s):
L-kynurenine hydrolaseUniRule annotation
Gene namesi
Name:kynUUniRule annotation
ORF Names:AQJ11_16400Imported
OrganismiStreptomyces corchorusii (Streptomyces chibaensis)Imported
Taxonomic identifieri1903 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000053398 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei230N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 329Aminotran_5InterPro annotationAdd BLAST251

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni135 – 138Pyridoxal phosphate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the kynureninase family.UniRule annotation

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01970 Kynureninase, 1 hit
InterProiView protein in InterPro
IPR000192 Aminotrans_V_dom
IPR010111 Kynureninase
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR14084 PTHR14084, 1 hit
PfamiView protein in Pfam
PF00266 Aminotran_5, 1 hit
PIRSFiPIRSF038800 KYNU, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01814 kynureninase, 1 hit

Sequencei

Sequence statusi: Complete.

A0A101QBE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELPQLAKE LDQADELAPL RDRFVLDSAS GDAAGPAGVY LDGNSLGALP
60 70 80 90 100
AHVPDRVADV VRRQWGELRI RSWEESGWWT APERIGDRIA PLVGAAPGQI
110 120 130 140 150
VVGDSTSVNV FKALVAAIRM ADAGRDEILV DATTFPTDGY IAESAARLTG
160 170 180 190 200
RTLRAVTPAE VPAALGDRTA AVLLNHVDYR TGRLHDLPAL TAAVHACGAL
210 220 230 240 250
AVWDLCHSAG ALPVGLDEHG VDLAVGCTYK YLNGGPGSPA YLYVRRELQD
260 270 280 290 300
RFDSPLPGWN SHAEPFGMSP SYAPAAGAVR GRVGTPDILS LLALEAALDV
310 320 330 340 350
WDGVSVDAVR AKSLALTDFF LRCVDEYTEP GRVECVTPGP HAERGSQIAL
360 370 380 390 400
RCPDAGEVMK RLIARGVVGD FRHPDILRFG FTPLYVSFRD AERAARTLGE

ELA
Length:403
Mass (Da):43,031
Last modified:April 13, 2016 - v1
Checksum:i06D5FA04B83AF71B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LMWP01000017 Genomic DNA Translation: KUN26869.1
RefSeqiWP_059263556.1, NZ_KQ948356.1

Genome annotation databases

EnsemblBacteriaiKUN26869; KUN26869; AQJ11_16400

Similar proteinsi

Entry informationi

Entry nameiA0A101QBE3_STRCK
AccessioniPrimary (citable) accession number: A0A101QBE3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 13, 2016
Last sequence update: April 13, 2016
Last modified: March 28, 2018
This is version 11 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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