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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Anaerolineaceae bacterium 46_22
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei590ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotation, Ligase
Biological processProtein biosynthesisUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
ORF Names:XE06_0404Imported
OrganismiAnaerolineaceae bacterium 46_22Imported
Taxonomic identifieri1635294 [NCBI]
Taxonomic lineageiBacteriaChloroflexiAnaerolineaeAnaerolinealesAnaerolineaceae

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini227 – 411tRNA-synt_1_2InterPro annotationAdd BLAST185
Domaini425 – 615tRNA-synt_1InterPro annotationAdd BLAST191
Domaini663 – 780Anticodon_1InterPro annotationAdd BLAST118

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi47 – 57"HIGH" regionUniRule annotationAdd BLAST11
Motifi587 – 591"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit

Sequencei

Sequence statusi: Complete.

A0A101IKW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDPTSIPTY KPEVIEPKWQ KQWEDDGLYH ADIDPNKPKF YALTMLPYPS
60 70 80 90 100
GDLHIGHWYA MTPSDARARF KRLQGYNVLF PMGFDAFGLP AENAAIQRGI
110 120 130 140 150
HPQTWTFRNI DNMRRQLKSM GAMFDWRREA ISAEPSYYKW TQWFFIKFFQ
160 170 180 190 200
NDLAYQKEAP VDFCPNCNTT LAREQVQGED RHCERCGTPV IKKNLTQWFF
210 220 230 240 250
RTTNYADELL DFSGMDWPEQ VQTLQTNWIN RSEGASVIFK TETGDNIEVF
260 270 280 290 300
TTRPDTLWGA TFMVLAPEHP LVPKLTSESQ EEEVAAYQDQ AKRMGDIQRE
310 320 330 340 350
SAEREKTGVF TGAYAINPVN NKKIPVWIAD YVMMGYGTGA IMAVPAHDQR
360 370 380 390 400
DFEFARKFDL PIEVVIQPPD IDPIIPEEME GAVPASGEMV NSGPLTGTPG
410 420 430 440 450
DIAFDKAAQY LEEHEIGKRA VNYRLRDWLI SRQRYWGAPI PIIHCPKCGA
460 470 480 490 500
VAVPEADLPV RLPEDVEWLP TGESPLKLHP TWRLTECPKC GGQAERETDT
510 520 530 540 550
MDTFMCSSWY HLRYLSPDYD EYPFDPKEYD YWMPVDTYTG GIEHATMHLI
560 570 580 590 600
YTRFFHKACR DLGITKGKEP MLQLRNQGMV LGEDNEKMSK SRGNVISPDD
610 620 630 640 650
LVEAYGADTV RAYLMFFARW ELGAPWNSSG IEGSIRWLRK VWYTFLEPVE
660 670 680 690 700
NDRQPTEEAV KNLRRKVHQT LQSVTRDFET FNFNTIVSGL MELLNEMNTA
710 720 730 740 750
KALGVFSTEA WKEAESIYLR MLAPVCPHIA EEIWCQTGYE YSIHNQAWPQ
760 770 780 790 800
VDVEATHEEE ITLIVQVNGK LRDRLVVPVN ITEAQAKQAA LDSENVQNFI
810 820
EGKQPRKVIY VPGRLVNIVV
Length:820
Mass (Da):94,210
Last modified:April 13, 2016 - v1
Checksum:iEFD7AC9EDEA0D30A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LGHA01000027 Genomic DNA Translation: KUK97097.1

Genome annotation databases

PATRICifig|1635294.3.peg.1339

Similar proteinsi

Entry informationi

Entry nameiA0A101IKW8_9CHLR
AccessioniPrimary (citable) accession number: A0A101IKW8
Entry historyiIntegrated into UniProtKB/TrEMBL: April 13, 2016
Last sequence update: April 13, 2016
Last modified: April 25, 2018
This is version 16 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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