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Protein

Isoleucine--tRNA ligase

Gene

XD58_1564

Organism
Thermotoga sp. 50_1627
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile).SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetaseUniRule annotationSAAS annotation, Ligase
Biological processProtein biosynthesisUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Isoleucine--tRNA ligaseSAAS annotation (EC:6.1.1.5SAAS annotation)
Gene namesi
ORF Names:XD58_1564Imported
OrganismiThermotoga sp. 50_1627Imported
Taxonomic identifieri1635260 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Subcellular locationi

GO - Cellular componenti

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 631tRNA-synt_1InterPro annotationAdd BLAST606
Domaini674 – 731Anticodon_1InterPro annotationAdd BLAST58

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd07960 Anticodon_Ia_Ile_BEm, 1 hit
Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_02002 Ile_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR033708 Anticodon_Ile_BEm
IPR002301 Ile-tRNA-ligase
IPR023585 Ile-tRNA-ligase_type1
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PRINTSiPR00984 TRNASYNTHILE
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00392 ileS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Fragment.

A0A101ETA5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDYKETLNLP NTAFPMRANL VEKEPQILER WKRIDIHRYI LRTREGRPTF
60 70 80 90 100
VLHDGPPYAN GAIHIGTAMN KILKDMVMRY KTLRGFKVPY VPGWDTHGLP
110 120 130 140 150
IEHRVTSMLK GKAEKMTPQQ IRQECEKFAR EQIEIQKRQF QRLGVIGDWE
160 170 180 190 200
NYYATLEPEY EYRVYTVLKK FVEDGYVYRE KKPVLWCFTC GTALAQAEIE
210 220 230 240 250
YRDHVSPSIY VKFKMKDSKE YIVIWTTTPW TLPANTGIAV HPEETYVRLK
260 270 280 290 300
VDSEIWIVAE RLLEQFAKEV GLKHYSVLER FSGRLLEGRI AISPLSQGDS
310 320 330 340 350
RVILADFVDM ETGTGCVHVA PGHGEEDYEY GYKIYRLDVL SPVDERGRFT
360 370 380 390 400
GEAGKYEGLN VFDANTIIVE DLKKLGALLH ASTITHSYPH CWRCKNPVIF
410 420 430 440 450
RATEQWFISI DRNNLRNRLL EQIEKVEWIP EWGKNRIAAM IEERPDWCIS
460 470 480 490 500
RQRVWGIPIP AFRCKSCGHV NLDPQLIEHF ASVVRQKGTN AWFEMSEKEL
510 520 530 540 550
LPDGYVCKNC GSNDLEKTYD TLDVWIDSGA SFEAVLNARP ELTFPADMYL
560 570 580 590 600
EGSDQHRGWF NSSLVLSVVK HGQPPYRTVL THGFIKDEEG KKMSKSLGNV
610 620 630 640 650
VDPLEVCSKY GADVLRLWLA SSDYFNDIRI SYNILKQQVE VYKKIRNTIR
660 670 680 690 700
YLLGNLYDFT PKDVVPYEKL LPVDKWALGR LQQIIKTVTE AYESYEISKV
710 720 730
YNILVKYCSV ELSAVYLDIV KDRLYVEGKN SLKRRSA
Length:737
Mass (Da):85,505
Last modified:April 13, 2016 - v1
Checksum:i7D9C9F3456A36765
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei737Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LGFH01000029 Genomic DNA Translation: KUK24464.1

Similar proteinsi

Entry informationi

Entry nameiA0A101ETA5_9THEM
AccessioniPrimary (citable) accession number: A0A101ETA5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 13, 2016
Last sequence update: April 13, 2016
Last modified: April 25, 2018
This is version 13 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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