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Protein

L-lactate dehydrogenase

Gene

ldh

Organism
Mycobacterium sp. GA-1199
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of lactate to pyruvate.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Activity regulationi

Allosterically activated by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei20NAD; via amide nitrogenUniRule annotation1
Binding sitei41NADUniRule annotation1
Binding sitei46NADUniRule annotation1
Binding sitei89SubstrateUniRule annotation1
Binding sitei95SubstrateUniRule annotation1
Binding sitei127SubstrateUniRule annotation1
Binding sitei150NADUniRule annotation1
Binding sitei158SubstrateUniRule annotation1
Binding sitei160Allosteric activatorUniRule annotation1
Binding sitei175Allosteric activatorUniRule annotation1
Active sitei182Proton acceptorUniRule annotation1
Binding sitei237SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi86 – 87NADUniRule annotation2
Nucleotide bindingi125 – 127NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzymeUniRule annotation, OxidoreductaseUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00554;UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Short name:
L-LDHUniRule annotation
Gene namesi
Name:ldhUniRule annotation
ORF Names:AU198_22990Imported
OrganismiMycobacterium sp. GA-1199Imported
Taxonomic identifieri1772287 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacterium
Proteomesi
  • UP000053437 Componenti: Unassembled WGS sequence

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei228PhosphotyrosineUniRule annotation1

Keywords - PTMi

PhosphoproteinUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 149Ldh_1_NInterPro annotationAdd BLAST139
Domaini152 – 314Ldh_1_CInterPro annotationAdd BLAST163

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 130Substrate bindingUniRule annotation4
Regioni155 – 158Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotation

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

A0A101BR44-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTESLRGRSN KVSIVGMGSV GTAIAYACLI RGSAGSLALY DVDAKKLRAE
60 70 80 90 100
VLDLNHGSQF VPHCPISGSD DVGVTAGSKV VIVTAGAKQH EGQSRLDLAT
110 120 130 140 150
SNVAMAQALT PQLLEHSPDA IIVLVTNPVD VVTYAAVRSV DIPAGRVFGS
160 170 180 190 200
GTVLDSSRFR YLIAERADLA IANVHGYIVG EHGDSQISLW STVSIGGVPA
210 220 230 240 250
SHFRIGGAVV FDEATRNQIS ADVVNAAYEI IAGKGATSLA IGLSTARIVE
260 270 280 290 300
AILGDQHRVL PVSTVQNGVY GISDVCLSLP TVVTAAGAGQ VLELSLSEPE
310 320
LTGLQTSAAT LKQAQSSLGL
Length:320
Mass (Da):32,950
Last modified:April 13, 2016 - v1
Checksum:i9E45D55D8DB2A9DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
LQIX01000018 Genomic DNA Translation: KUI45730.1
RefSeqiWP_064348709.1, NZ_LQIX01000018.1

Genome annotation databases

EnsemblBacteriaiKUI45730; KUI45730; AU198_22990

Similar proteinsi

Entry informationi

Entry nameiA0A101BR44_9MYCO
AccessioniPrimary (citable) accession number: A0A101BR44
Entry historyiIntegrated into UniProtKB/TrEMBL: April 13, 2016
Last sequence update: April 13, 2016
Last modified: September 12, 2018
This is version 15 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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